Search Results - "Hernandez, Laura L"

Perspective: Transient postparturient hypocalcemia-A lactation-induced phenomenon of high-producing dairy cows by Hernandez, Laura L, McArt, Jessica A A

“…Milk fever is one of the most historically relevant diseases of dairy cows. It is caused by tremendous calcium (Ca) expenditure at the initiation of lactation,…”
Get full text

Exploring the contribution of mammary-derived serotonin on liver and pancreas metabolism during lactation by Field, Sena L, Galvan, Everardo Anta, Hernandez, Laura L, Laporta, Jimena

“…During lactation, the murine mammary gland is responsible for a significant increase in circulating serotonin. However, the role of mammary-derived serotonin…”
Get full text

Serotonin stimulated parathyroid hormone related protein induction in the mammary epithelia by transglutaminase-dependent serotonylation by Sheftel, Celeste M, Hernandez, Laura L

“…Mammary-derived serotonin has been implicated in breast-to-bone communication during lactation by increasing parathyroid hormone related-protein (PTHrP) in the…”
Get full text

Investigating the influence of perinatal fluoxetine exposure on murine gut microbial communities during pregnancy and lactation by Desorcy-Scherer, Katelyn, Zuniga-Chaves, Ibrahim, Reisner, Maggie A., Suen, Garret, Hernandez, Laura L.

“…Selective Serotonin Reuptake Inhibitor (SSRI) therapy is common among perinatal populations for the treatment of mood disorders. Medications can affect…”
Get full text

Investigating the effect of positional variation on mid-lactation mammary gland transcriptomics in mice fed either a low-fat or high-fat diet by Cheng, Adrienne A, Li, Wenli, Hernandez, Laura L

“…Little attention has been given to the effect of positional variation of gene expression in the mammary gland. However, more research is shedding light…”
Get full text

Mammary gland serotonin regulates parathyroid hormone-related protein and other bone-related signals by Hernandez, Laura L, Gregerson, Karen A, Horseman, Nelson D

“…Breast cells drive bone demineralization during lactation and metastatic cancers. A shared mechanism among these physiological and pathological states is…”
Get more information

Functional Inactivation of Mast Cells Enhances Subcutaneous Adipose Tissue Browning in Mice by Zhang, Xian, Wang, Xin, Yin, Hao, Zhang, Lei, Feng, Airong, Zhang, Qiu-Xia, Lin, Yan, Bao, Bin, Hernandez, Laura L., Shi, Guo-Ping, Liu, Jian

“…Adipose tissue browning and systemic energy expenditure provide a defense mechanism against obesity and associated metabolic diseases. In high-cholesterol…”
Get full text

In vitro effects of 5-Hydroxy-L-tryptophan supplementation on primary bovine mammary epithelial cell gene expression under thermoneutral or heat shock conditions by Field, Sena L., Ouellet, Véronique, Sheftel, Celeste M., Hernandez, Laura L., Laporta, Jimena

“…Serotonin (5-HT) is an autocrine-paracrine molecule within the mammary gland regulating homeostasis during lactation and triggering involution after milk…”
Get full text

Intravenous infusion of 5-hydroxytryptophan to mid-lactation Holstein cows transiently affects milk production and circulating amino acid concentrations by Pszczolkowski, Virginia L., Connelly, Meghan K., Hoppman, August, Benn, Amara D., Laporta, Jimena, Hernandez, Laura L., Arriola Apelo, Sebastian I.

“…In dairy cows, the lactating mammary glands synthesize serotonin, which acts in an autocrine-paracrine manner in the glands and is secreted into the periphery…”
Get full text

Peripheral serotonin regulates maternal calcium trafficking in mammary epithelial cells during lactation in mice by Laporta, Jimena, Keil, Kimberly P, Vezina, Chad M, Hernandez, Laura L

“…Lactation is characterized by massive transcellular flux of calcium, from the basolateral side of the mammary alveolar epithelium (blood) into the ductal lumen…”
Get full text

New selenosteroids as antiproliferative agents by Fuentes-Aguilar, Alma, Romero-Hernández, Laura L, Arenas-González, Ailed, Merino-Montiel, Penélope, Montiel-Smith, Sara, Meza-Reyes, Socorro, Vega-Báez, José Luis, Plata, Gabriela B, Padrón, José M, López, Óscar, Fernández-Bolaños, José G

“…Starting from natural steroids (diosgenin, hecogenin, smilagenin, estrone), we have prepared a wide panel of selenoderivatives, including benzoselenazolones,…”
Get more information

The antidepressant fluoxetine (Prozac®) modulates serotonin signaling to alter maternal peripartum calcium homeostasis by Domingues, Rafael R., Teixeira, Natalia N., Frizzarini, Waneska S., Beard, Adam D., Connelly, Meghan K., Vang, Alysia, Wiltbank, Milo C., Hernandez, Laura L.

“…Antidepressant use is two-fold greater in women compared to men; however, most studies have been performed in male subjects. We aimed to understand the impact…”
Get full text

Diosgenin-based thio(seleno)ureas and triazolyl glycoconjugates as hybrid drugs. Antioxidant and antiproliferative profile by Romero-Hernández, Laura L., Merino-Montiel, Penélope, Montiel-Smith, Sara, Meza-Reyes, Socorro, Vega-Báez, José Luis, Abasolo, Ibane, Schwartz, Simó, López, Óscar, Fernández-Bolaños, José G.

“…The stereoselective preparation of diosgenin-derived thio(seleno)ureas and glycomimetics bearing a 1,2,3-triazolyl tether on C-3 has been accomplished. The key…”
Get full text

Synthesis of unprecedented steroidal spiro heterocycles as potential antiproliferative drugs by Romero-Hernández, Laura L., Merino-Montiel, Penélope, Meza-Reyes, Socorro, Vega-Baez, José Luis, López, Óscar, Padrón, José M., Montiel-Smith, Sara

“…Herein we report the straightforward preparation of novel conformationally-restricted steroids from trans-androsterone and estrone, decorated with spiranic…”
Get full text

Identification of genetic variants and individual genes associated with postpartum hypocalcemia in Holstein cows by Novo, Larissa C., Poindexter, Michael B., Rezende, Fernanda M., Santos, José E. P., Nelson, Corwin D., Hernandez, Laura L., Kirkpatrick, Brian W., Peñagaricano, Francisco

“…Periparturient hypocalcemia is a complex metabolic disorder that occurs at the onset of lactation because of a sudden irreversible loss of Ca incorporated into…”
Get full text

Synthesis, antiproliferative evaluation and in silico studies of a novel steroidal spiro morpholinone by Cobos-Ontiveros, Luis A., Romero-Hernández, Laura L., Mastranzo-Sánchez, Eduardo B., Colín-Lozano, Blanca, Puerta, Adrián, Padrón, José M., Merino-Montiel, Penélope, Vega Baez, Jose Luis, Montiel-Smith, Sara

“…[Display omitted] •A steroidal spiro morpholinone was prepared in six steps starting from estrone.•The spiro morpholinone and its hydroxychloroacetamide…”
Get full text

Conformationally Restricted Glycoconjugates Derived from Arylsulfonamides and Coumarins: New Families of Tumour-Associated Carbonic Anhydrase Inhibitors by Martínez-Montiel, Mónica, Romero-Hernández, Laura L, Giovannuzzi, Simone, Begines, Paloma, Puerta, Adrián, Ahuja-Casarín, Ana I, Fernandes, Miguel X, Merino-Montiel, Penélope, Montiel-Smith, Sara, Nocentini, Alessio, Padrón, José M, Supuran, Claudiu T, Fernández-Bolaños, José G, López, Óscar

“…The involvement of carbonic anhydrases (CAs) in a myriad of biological events makes the development of new inhibitors of these metalloenzymes a hot topic in…”
Get full text

Transcriptomic Analysis of the Mouse Mammary Gland Reveals New Insights for the Role of Serotonin in Lactation by Laporta, Jimena, Peñagaricano, Francisco, Hernandez, Laura L

“…Serotonin regulates numerous processes in the mammary gland. Our objective was to discover novel genes, pathways and functions which serotonin modulates during…”
Get full text

Altered serotonin physiology in human breast cancers favors paradoxical growth and cell survival by Pai, Vaibhav P, Marshall, Aaron M, Hernandez, Laura L, Buckley, Arthur R, Horseman, Nelson D

“…The breast microenvironment can either retard or accelerate the events associated with progression of latent cancers. However, the actions of local…”
Get full text

Elevating serotonin pre-partum alters the Holstein dairy cow hepatic adaptation to lactation by Weaver, Samantha R, Prichard, Allan S, Maerz, Noah L, Prichard, Austin P, Endres, Elizabeth L, Hernández-Castellano, Lorenzo E, Akins, Matthew S, Bruckmaier, Rupert M, Hernandez, Laura L

“…Serotonin is known to regulate energy and calcium homeostasis in several mammalian species. The objective of this study was to determine if pre-partum…”
Get full text