Search Results - "Hernandez, Jonathan J"
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cMyBP-C ablation in human engineered cardiac tissue causes progressive Ca2+-handling abnormalities
Published in The Journal of general physiology (03-04-2023)“…Truncation mutations in cardiac myosin binding protein C (cMyBP-C) are common causes of hypertrophic cardiomyopathy (HCM). Heterozygous carriers present with…”
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Dodging COVID-19 infection: low expression and localization of ACE2 and TMPRSS2 in multiple donor-derived lines of human umbilical cord-derived mesenchymal stem cells
Published in Journal of translational medicine (14-04-2021)“…Mesenchymal stem cells derived from human umbilical cord (hUC-MSCs) have immunomodulatory properties that are of interest to treat novel coronavirus disease…”
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3
Pareto Optimal Spectrally Selective Emitters for Thermophotovoltaics via Weak Absorber Critical Coupling
Published in Advanced energy materials (05-09-2018)“…Tailoring the emission spectra of a thermophotovoltaic (TPV) emitter away from that of a blackbody has the potential to minimize transmission and…”
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4
Caveolae-Mediated Activation of Mechanosensitive Chloride Channels in Pulmonary Veins Triggers Atrial Arrhythmogenesis
Published in Journal of the American Heart Association (15-10-2019)“…Background Atrial fibrillation often occurs in the setting of hypertension and associated atrial dilation with pathologically increased cardiomyocyte stretch…”
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5
Preserved cardiac performance and adrenergic response in a rabbit model with decreased ryanodine receptor 2 expression
Published in Journal of molecular and cellular cardiology (01-06-2022)“…Ryanodine receptor 2 (RyR2) is an ion channel in the heart responsible for releasing into the cytosol most of the Ca2+ required for contraction. Proper…”
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6
Atrial Infarction-Induced Spontaneous Focal Discharges and Atrial Fibrillation in Sheep: Role of Dantrolene-Sensitive Aberrant Ryanodine Receptor Calcium Release
Published in Circulation. Arrhythmia and electrophysiology (01-03-2018)“…BACKGROUND:The mechanisms underlying spontaneous atrial fibrillation (AF) associated with atrial ischemia/infarction are incompletely elucidated. Here, we…”
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Arrhythmogenic mechanisms in ryanodine receptor channelopathies
Published in Science China. Life sciences (01-01-2015)“…Ryanodine receptors(Ry Rs) are the calcium release channels of sarcoplasmic reticulum(SR) that provide the majority of calcium ions(Ca^2+) necessary to induce…”
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Cardiac hypertrophy and arrhythmia in mice induced by a mutation in ryanodine receptor 2
Published in JCI insight (04-04-2019)“…Hypertrophic cardiomyopathy (HCM) is triggered mainly by mutations in genes encoding sarcomeric proteins, but a significant proportion of patients lack a…”
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9
Spray-deposition of graphene/polymer thin coatings on polyimide sheets for lunar dust adhesion mitigation
Published in Acta astronautica (01-06-2024)“…NASA seeks to develop technologies to mitigate dust accumulation from planetary surfaces on robotic and human systems hardware during planned space exploration…”
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Abstract 16773: Ablation of Cardiac Myosin Binding Protein-C in Human iPSC- Engineered Cardiac Tissue Model Causes Increased Calcium Sensitivity and Accelerated Contractile Kinetics
Published in Circulation (New York, N.Y.) (06-11-2018)“…Hypertrophic cardiomyopathy (HCM) is an inherited cardiac disease that can cause sudden cardiac arrest, diastolic dysfunction and heart failure. Mutations in…”
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11
Pareto Optimal Spectrally Selective Emitters for Thermophotovoltaics via Weak Absorber Critical Coupling
Published in Advanced energy materials (15-07-2018)“…Tailoring the emission spectra of a thermophotovoltaic (TPV) emitter away from that of a blackbody has the potential to minimize transmission and…”
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Journal Article -
12
Characterization of catecholaminergic polymorphic ventricular tachycardia mechanisms using patient-specific human induced pluripotent stem cells and a transgenic mouse harboring the H2464D mutation in the cardiac ryanodine receptor
Published 01-01-2016“…Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) is an inherited arrhythmogenic disease characterized by syncopal events, triggered by exercise or…”
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Dissertation -
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Abstract 18946: A Complex Cardiac Rhythm and Conduction Abnormalities in Three Families Carrying a SCN5A Missense Mutation May Involve Single Nucleotide Polymorphisms in SCN5A and RYR2 genes
Published in Circulation (New York, N.Y.) (25-11-2014)“…Abstract only Background: Mutations in the gene encoding the cardiac sodium channel (SCN5A) have been implicated in arrhythmia syndromes including Brugada…”
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