Search Results - "Hernandez, Ivó"

Faulty splicing and cytoskeleton abnormalities in Huntington's disease by Fernández-Nogales, Marta, Santos-Galindo, María, Hernández, Ivó H., Cabrera, Jorge R., Lucas, José J.

“…Huntington's disease (HD) is caused by a CAG‐repeat encoding a polyglutamine (polyQ) tract in the huntingtin protein. There is plenty of evidence of…”
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The anti-leprosy drug clofazimine reduces polyQ toxicity through activation of PPARγ by Li, Xuexin, Hernandez, Ivó, Koyuncu, Seda, Kis, Balázs, Häggblad, Maria, Lidemalm, Louise, Abbas, Anna A., Bendegúz, Sramkó, Göblös, Anikó, Brautigam, Lars, Lucas, Jose J., Carreras-Puigvert, Jordi, Hühn, Daniela, Pircs, Karolina, Vilchez, David, Fernandez-Capetillo, Oscar

“…PolyQ diseases are autosomal dominant neurodegenerative disorders caused by the expansion of CAG repeats. While of slow progression, these diseases are…”
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Glial Cells as Therapeutic Approaches in Brain Ischemia-Reperfusion Injury by Hernández, Ivó H, Villa-González, Mario, Martín, Gerardo, Soto, Manuel, Pérez-Álvarez, María José

“…Ischemic stroke is the second cause of mortality and the first cause of long-term disability constituting a serious socioeconomic burden worldwide. Approved…”
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Huntington's disease-specific mis-splicing unveils key effector genes and altered splicing factors by Elorza, Ainara, Márquez, Yamile, Cabrera, Jorge R, Sánchez-Trincado, José Luis, Santos-Galindo, María, Hernández, Ivó H, Picó, Sara, Díaz-Hernández, Juan I, García-Escudero, Ramón, Irimia, Manuel, Lucas, José J

“…Correction of mis-splicing events is a growing therapeutic approach for neurological diseases such as spinal muscular atrophy or neuronal ceroid lipofuscinosis…”
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Focal cerebral ischemia induces changes in oligodendrocytic tau isoforms in the damaged area by Villa González, Mario, Vallés‐Saiz, Laura, Hernández, Ivó H., Avila, Jesús, Hernández, Félix, Pérez‐Alvarez, María José

“…Ischemic stroke is a major cause of death and the first leading cause of long‐term disability worldwide. The only therapeutic strategy available to date is…”
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Glial cells in the center of future ischemic stroke treatments by Hernández, Ivó, Pérez-Álvarez, Maria

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Huntingtin-mediated axonal transport requires arginine methylation by PRMT6 by Migazzi, Alice, Scaramuzzino, Chiara, Anderson, Eric N., Tripathy, Debasmita, Hernández, Ivó H., Grant, Rogan A., Roccuzzo, Michela, Tosatto, Laura, Virlogeux, Amandine, Zuccato, Chiara, Caricasole, Andrea, Ratovitski, Tamara, Ross, Christopher A., Pandey, Udai B., Lucas, José J., Saudou, Frédéric, Pennuto, Maria, Basso, Manuela

“…The huntingtin (HTT) protein transports various organelles, including vesicles containing neurotrophic factors, from embryonic development throughout life. To…”
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Pathogenic SREK1 decrease in Huntington's disease lowers TAF1 mimicking X-linked dystonia parkinsonism by Hernández, Ivó H, Cabrera, Jorge R, Santos-Galindo, María, Sánchez-Martín, Manuel, Domínguez, Verónica, García-Escudero, Ramón, Pérez-Álvarez, María J, Pintado, Belén, Lucas, José J

“…Huntington's disease and X-linked dystonia parkinsonism are two monogenic basal ganglia model diseases. Huntington's disease is caused by a…”
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A new non-aggregative splicing isoform of human Tau is decreased in Alzheimer’s disease by García-Escudero, Vega, Ruiz-Gabarre, Daniel, Gargini, Ricardo, Pérez, Mar, García, Esther, Cuadros, Raquel, Hernández, Ivó H., Cabrera, Jorge R., García-Escudero, Ramón, Lucas, José J., Hernández, Félix, Ávila, Jesús

“…Tauopathies, including Alzheimer’s disease (AD) and frontotemporal lobar degeneration with Tau pathology (FTLD-tau), are a group of neurodegenerative disorders…”
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Pathogenic Mis-splicing of CPEB4 in Schizophrenia by Ollà, Ivana, Pardiñas, Antonio F., Parras, Alberto, Hernández, Ivó H., Santos-Galindo, María, Picó, Sara, Callado, Luis F., Elorza, Ainara, Rodríguez-López, Claudia, Fernández-Miranda, Gonzalo, Belloc, Eulàlia, Walters, James T.R., O’Donovan, Michael C., Méndez, Raúl, Toma, Claudio, Meana, J. Javier, Owen, Michael J., Lucas, José J.

“…Schizophrenia (SCZ) is caused by an interplay of polygenic risk and environmental factors, which may alter regulators of gene expression leading to pathogenic…”
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CPEB alteration and aberrant transcriptome-polyadenylation lead to a treatable SLC19A3 deficiency in Huntington's disease by Picó, Sara, Parras, Alberto, Santos-Galindo, María, Pose-Utrilla, Julia, Castro, Margarita, Fraga, Enrique, Hernández, Ivó H, Elorza, Ainara, Anta, Héctor, Wang, Nan, Martí-Sánchez, Laura, Belloc, Eulàlia, Garcia-Esparcia, Paula, Garrido, Juan J, Ferrer, Isidro, Macías-García, Daniel, Mir, Pablo, Artuch, Rafael, Pérez, Belén, Hernández, Félix, Navarro, Pilar, López-Sendón, José Luis, Iglesias, Teresa, Yang, X William, Méndez, Raúl, Lucas, José J

“…Huntington’s disease (HD) is a hereditary neurodegenerative disorder of the basal ganglia for which disease-modifying treatments are not yet available…”
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TAF1 SPLICING VARIANTS AND PROLYL HYDROXYLASE INHIBITORS IN HUNTINGTON’S DISEASE by Rodríguez-López, Claudia, Hernández, Ivó Hernández, González-Bermejo, María, Barbero, Marcos Casado, Lucas, José

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The neuroprotective transcription factor ATF5 is decreased and sequestered into polyglutamine inclusions in Huntington’s disease by Hernández, Ivó H., Torres-Peraza, Jesús, Santos-Galindo, María, Ramos-Morón, Eloísa, Fernández-Fernández, M. Rosario, Pérez-Álvarez, María J., Miranda-Vizuete, Antonio, Lucas, José J.

“…Activating transcription factor-5 (ATF5) is a stress-response transcription factor induced upon different cell stressors like fasting, amino-acid limitation,…”
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The regulation of proteostasis in glial cells by nucleotide receptors is key in acute neuroinflammation by Diego García, Laura, Sebastián-Serrano, Álvaro, Hernández, Ivó H., Pintor, Jesús, Lucas, José J., Díaz-Hernández, Miguel

“…ABSTRACT The disturbances of cellular proteostasis caused by the alteration in the ubiquitin‐proteasome system (UPS) have been proposed as a common mechanism…”
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Differential regulation of Kidins220 isoforms in Huntington's disease by Sebastián‐Serrano, Álvaro, Simón‐García, Ana, Belmonte‐Alfaro, Alicia, Pose‐Utrilla, Julia, Santos‐Galindo, María, del Puerto, Ana, García‐Guerra, Lucía, Hernández, Ivó H., Schiavo, Giampietro, Campanero, Miguel R., Lucas, José J., Iglesias, Teresa

“…Huntington's disease (HD) is an inherited progressive neurodegenerative disease characterized by brain atrophy particularly in the striatum that produces motor…”
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Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing by Parras, Alberto, Anta, Héctor, Santos-Galindo, María, Swarup, Vivek, Elorza, Ainara, Nieto-González, José L., Picó, Sara, Hernández, Ivó H., Díaz-Hernández, Juan I., Belloc, Eulàlia, Rodolosse, Annie, Parikshak, Neelroop N., Peñagarikano, Olga, Fernández-Chacón, Rafael, Irimia, Manuel, Navarro, Pilar, Geschwind, Daniel H., Méndez, Raúl, Lucas, José J.

“…Common genetic contributions to autism spectrum disorder (ASD) reside in risk gene variants that individually have minimal effect sizes. As environmental…”
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A11 Huntingtin-mediated axonal transport requires arginine methylation by PRMT6 by Migazzi, Alice, Scaramuzzino, Chiara, Anderson, Eric, Tripathy, Debasmita, Hernández, Ivó H, Grant, Rogan, Roccuzzo, Michela, Tosatto, Laura, Virlogeux, Amandine, Zuccato, Chiara, Caricasole, Andrea, Ratovitski, Tamara, Ross, Christopher A, Pandey, Udai, Lucas, José J, Saudou, Frédéric, Pennuto, Maria, Basso, Manuela

“…BackgroundNeuronal function depends heavily on the ability to transport various molecules along axons. The huntingtin (HTT) protein transports various…”
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I03 CPEB alteration and aberrant transcriptome-polyadenylation unveil a treatable vitamin B1 deficiency in huntington’s disease by Pico, Sara, Parras, Alberto, Santos-Galindo, María, Pose-Utrilla, Julia, Castro, Margarita, Fraga, Enrique, Hernández, Ivó H, Elorza, Ainara, Anta, Héctor, Wang, Nan, Martí-Sánchez, Laura, Belloc, Eulàlia, Garcia-Esparcia, Paula, Garrido, Juan J, Ferrer, Isidro, Macías-García, Daniel, Mir, Pablo, Artuch, Rafael, Pérez, Belén, Hernández, Félix, Navarro, Pilar, López-Sendón, José Luis, Iglesias, Teresa, William Yang, X, Méndez, Raúl, Lucas, José J

“…BackgroundAlthough promising gene-silencing therapies are being tested for Huntington’s disease (HD), no disease-modifying treatments are available. Thus,…”
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Faulty splicing and cytoskeleton abnormalities in H untington's disease by Fernández‐Nogales, Marta, Santos‐Galindo, María, Hernández, Ivó H., Cabrera, Jorge R., Lucas, José J.

“…Huntington's disease (HD) is caused by a CAG‐repeat encoding a polyglutamine (polyQ) tract in the huntingtin protein. There is plenty of evidence of…”
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The anti-leprosy drug clofazimine reduces polyQ toxicity through activation of PPARγ γ by Li, X, Hernandez, I, Koyuncu, S, Haeggblad, M, Lidemalm, L, Abbas, AA, Bendeguz, S, Goebloes, A, Brautigam, L, Lucas, JJ

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