Search Results - "Hernán, Miguel A."

Methods of Public Health Research — Strengthening Causal Inference from Observational Data by Hernán, Miguel A

“…For researchers using observational data, a useful way to answer a causal question is to design the target trial that would answer it and then emulate its…”
Get full text

Why Test for Proportional Hazards? by Stensrud, Mats J, Hernán, Miguel A

“…This JAMA Guide to Statistics and Methods explains the meaning underlying the proportional hazards (PH) assumption underlying Cox regression and survival…”
Get full text

Per-Protocol Analyses of Pragmatic Trials by Hernán, Miguel A, Robins, James M

“…Pragmatic trials are designed to address real-world questions about care options. This article addresses issues that may arise from per-protocol and…”
Get full text

Target Trial Emulation: A Framework for Causal Inference From Observational Data by Hernán, Miguel A, Wang, Wei, Leaf, David E

“…This Guide to Statistics and Methods describes the use of target trial emulation to design an observational study so it preserves the advantages of a…”
Get full text

Specifying a target trial prevents immortal time bias and other self-inflicted injuries in observational analyses by Hernán, Miguel A, Sauer, Brian C, Hernández-Díaz, Sonia, Platt, Robert, Shrier, Ian

“…Abstract Many analyses of observational data are attempts to emulate a target trial. The emulation of the target trial may fail when researchers deviate from…”
Get full text

The Hazards of Hazard Ratios by Hernán, Miguel A.

Get full text

Does water kill? A call for less casual causal inferences by Hernán, Miguel A

“…“Can this number be interpreted as a causal effect?” is a key question for scientists and decision makers. The potential outcomes approach, a quantitative…”
Get full text

Effectiveness of a third dose of the BNT162b2 mRNA COVID-19 vaccine for preventing severe outcomes in Israel: an observational study by Barda, Noam, Dagan, Noa, Cohen, Cyrille, Hernán, Miguel A, Lipsitch, Marc, Kohane, Isaac S, Reis, Ben Y, Balicer, Ran D

“…Many countries are experiencing a resurgence of COVID-19, driven predominantly by the delta (B.1.617.2) variant of SARS-CoV-2. In response, these countries are…”
Get full text

Temporal trends in the incidence of multiple sclerosis : A systematic review by ALONSO, Alvaro, HERNAN, Miguel A

“…Multiple sclerosis (MS) has been traditionally considered to be more frequent in women and in regions more distant from the equator. However, recent reports…”
Get full text

The Simpson's paradox unraveled by Hernán, Miguel A, Clayton, David, Keiding, Niels

“…Background In a famous article, Simpson described a hypothetical data example that led to apparently paradoxical results. Methods We make the causal structure…”
Get full text

Compound Treatments and Transportability of Causal Inference by Hernán, Miguel A., VanderWeele, Tyler J.

“…Ill-defined causal questions present serious problems for observational studies—problems that are largely unappreciated. This paper extends the usual…”
Get full text

The imprinting effect of covid-19 vaccines: an expected selection bias in observational studies by Monge, Susana, Pastor-Barriuso, Roberto, Hernán, Miguel A

Get more information

The value of explicitly emulating a target trial when using real world evidence: an application to colorectal cancer screening by García-Albéniz, Xabier, Hsu, John, Hernán, Miguel A.

“…Observational analyses for causal inference often rely on real world data collected for purposes other than research. A frequent goal of these observational…”
Get full text

Extending inferences from a randomized trial to a target population by Dahabreh, Issa J., Hernán, Miguel A.

“…In this issue, Weiss discusses “generalizing” inferences from randomized trials to other populations [1]. However, he does not explicitly define what…”
Get full text

Effectiveness of BNT162b2 Vaccine against Delta Variant in Adolescents by Reis, Ben Y, Barda, Noam, Leshchinsky, Michael, Kepten, Eldad, Hernán, Miguel A, Lipsitch, Marc, Dagan, Noa, Balicer, Ran D

“…A study involving more than 94,000 vaccinated and unvaccinated adolescents between the ages of 12 and 18 years in Israel showed increasing levels of protection…”
Get full text

Selection bias due to conditioning on a collider by Hernán, Miguel A, Monge, Susana

Get more information

Biases in Randomized Trials: A Conversation Between Trialists and Epidemiologists by Mansournia, Mohammad Ali, Higgins, Julian P. T., Sterne, Jonathan A. C., Hernán, Miguel A.

“…Trialists and epidemiologists often employ different terminology to refer to biases in randomized trials and observational studies, even though many biases…”
Get full text

Effect of Flexible Sigmoidoscopy Screening on Colorectal Cancer Incidence and Mortality: A Randomized Clinical Trial by Holme, Øyvind, Løberg, Magnus, Kalager, Mette, Bretthauer, Michael, Hernán, Miguel A, Aas, Eline, Eide, Tor J, Skovlund, Eva, Schneede, Jørn, Tveit, Kjell Magne, Hoff, Geir

“…IMPORTANCE: Colorectal cancer is a major health burden. Screening is recommended in many countries. OBJECTIVE: To estimate the effectiveness of flexible…”
Get full text

Win-Win: Reconciling Social Epidemiology and Causal Inference by Galea, Sandro, Hernán, Miguel A

“…Abstract Social epidemiology is concerned with the health effects of forces that are “above the skin.” Although causal inference should be a key goal for…”
Get full text

Gout and the risk of Alzheimer's disease: a population-based, BMI-matched cohort study by Lu, Na, Dubreuil, Maureen, Zhang, Yuqing, Neogi, Tuhina, Rai, Sharan K, Ascherio, Alberto, Hernán, Miguel A, Choi, Hyon K

“…While gout is associated with cardiovascular (CV)-metabolic comorbidities and their sequelae, the antioxidant effects of uric acid may have neuroprotective…”
Get more information