Incidence and Importance of De Novo Diabetes Mellitus After Heart Transplantation

Abstract Introduction Diabetes mellitus is one of the main metabolic complications after heart transplantation. The aims of our study were to determine the incidence and factors that determine the appearance of posttransplantation diabetes mellitus (PTDM) and its prognostic value. Materials and meth...

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Published in:	Transplantation proceedings Vol. 40; no. 9; pp. 3053 - 3055
Main Authors:	Mogollón Jiménez, M.V, Sobrino Márquez, J.M, Arizón Muñoz, J.M, Sánchez Brotons, J.A, Rasco, A. Guisado, Hernández Jiménez, M.M, Rodríguez, N. Romero, Borrego Domínguez, J.M, Fernández, A. Ordoñez, Gallé, E. Lage, Martínez, Á. Martínez
Format:	Journal Article Conference Proceeding
Language:	English
Published:	Amsterdam Elsevier Inc 01-11-2008 Elsevier
Subjects:	Biological and medical sciences Diabetes Mellitus - epidemiology Diabetes Mellitus - etiology Epidemiology Female Follow-Up Studies Fundamental and applied biological sciences. Psychology Fundamental immunology General aspects Heart Transplantation - adverse effects Heart Transplantation - immunology Heart Transplantation - mortality Humans Immunosuppressive Agents - therapeutic use Incidence Male Medical sciences Middle Aged Public health. Hygiene Public health. Hygiene-occupational medicine Recurrence Retrospective Studies Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Survival Rate Survivors Time Factors Tissue, organ and graft immunology Endocrinopathy Heart Diabetes mellitus Transplantation Homotransplantation Epidemiology De novo Incidence Medicine Treatment Surgery Graft Circulatory system
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Summary:	Abstract Introduction Diabetes mellitus is one of the main metabolic complications after heart transplantation. The aims of our study were to determine the incidence and factors that determine the appearance of posttransplantation diabetes mellitus (PTDM) and its prognostic value. Materials and methods We performed a retrospective study of all heart transplant recipients in our hospital from January 1993 to December 2005, including 116 patients with prolonged monitoring with 59-month median follow-up. We divided the patients into two groups, according to whether they had de novo diabetes (group 1) or no diabetes (group 2). Results Patients with PTDM were significantly older, with a median difference (MD) of 5.4 years (95% confidence interval [CI], 1.53–9.28) and a greater body mass index (MD, 3.37 kg/m2 ; 95% CI, 1.68–5.06). Moreover, a greater percentage of patients in group 1 had ischemia compared to other etiologies. However, no significant differences were observed regarding other cardiovascular risk factors. PTDM was associated with a greater incidence of posttransplant hypertension (51.6% in group 1 vs 48.4% in group 2, P = .08) and posttransplant renal failure (59.5% in group 1 vs 40.5% in group 2, P = .001). However, no differences were observed in overall survival. Conclusions Age, overweight, and ischemic origin of cardiopathy were the main risk factors for the development of PTDM in our population. Although no differences were observed in survival rates, PTDM was associated with a greater incidence of hypertension and renal insufficiency, which may have long-term influences on patient survival.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0041-1345 1873-2623
DOI:	10.1016/j.transproceed.2008.09.045