Search Results - "Hernández Fernández, Diana Rosa"
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Antitumor activity of PAbs generated by immunization with a novel HER3-targeting protein-based vaccine candidate in preclinical models
Published in Frontiers in oncology (16-10-2024)“…Despite the cumulative evidence supporting HER3 as a target for antitumor therapies, no agents targeting HER3 have been approved for cancer treatment. Most of…”
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Polyclonal antibody-induced downregulation of HER1/EGFR and HER2 surpasses the effect of combinations of specific registered antibodies
Published in Frontiers in oncology (02-11-2022)“…Background Antitumor therapies targeting HER1/EGFR and HER2, such as monoclonal antibodies (MAbs) and tyrosine-kinase inhibitors (TKIs), have demonstrated a…”
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Immuno-toxicological evaluation of her1 cancer vaccine in non-human primates: a 6-month subcutaneous study
Published in Immunopharmacology and immunotoxicology (04-05-2021)“…Purpose: A vaccine composition based on the extracellular domain of the human epidermal growth factor receptor 1 (HER1-ECD) and the combination of VSSP (very…”
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Anti-proliferative and pro-apoptotic effects induced by simultaneous inactivation of HER1 and HER2 through endogenous polyclonal antibodies
Published in Oncotarget (10-10-2017)“…The human epidermal growth factor receptor (HER1) and its partner HER2 are extensively described oncogenes and validated targets for cancer therapy. However,…”
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HER1-ECD vaccination dispenses with emulsification to elicit HER1-specific anti-proliferative effects
Published in Human vaccines (01-03-2009)“…EGFR (HER1) highlights as one of the most relevant tumour associated antigen in epithelial malignant cells. Monoclonal antibodies and tyrosine kinase…”
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Anti-EGFR activation, anti-proliferative and pro-apoptotic effects of polyclonal antibodies induced by EGFR-based cancer vaccine
Published in Vaccine (08-09-2008)“…Abstract Up to now clinical experiences focusing EGF receptor, an attractive target for cancer therapy, have been limited to passive therapies, suggesting that…”
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