Search Results - "Hernández‐Sanchez, María"

Chronic lymphocytic leukemia patients with IGH translocations are characterized by a distinct genetic landscape with prognostic implications by Pérez‐Carretero, Claudia, Hernández‐Sánchez, María, González, Teresa, Quijada‐Álamo, Miguel, Martín‐Izquierdo, Marta, Hernández‐Sánchez, Jesús‐María, Vidal, María‐Jesús, Coca, Alfonso García, Aguilar, Carlos, Vargas‐Pabón, Manuel, Alonso, Sara, Sierra, Magdalena, Rubio‐Martínez, Araceli, Dávila, Julio, Díaz‐Valdés, José R., Queizán, José‐Antonio, Hernández‐Rivas, José‐Ángel, Benito, Rocío, Rodríguez‐Vicente, Ana E., Hernández‐Rivas, Jesús‐María

“…Chromosome 14q32 rearrangements/translocations involving the immunoglobulin heavy chain (IGH) are rarely detected in chronic lymphocytic leukemia (CLL). The…”
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Decrease in coccolithophore calcification and CO2 since the middle Miocene by Bolton, Clara T., Hernández-Sánchez, María T., Fuertes, Miguel-Ángel, González-Lemos, Saúl, Abrevaya, Lorena, Mendez-Vicente, Ana, Flores, José-Abel, Probert, Ian, Giosan, Liviu, Johnson, Joel, Stoll, Heather M.

“…Marine algae are instrumental in carbon cycling and atmospheric carbon dioxide (CO 2 ) regulation. One group, coccolithophores, uses carbon to photosynthesize…”
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CRISPR/Cas9-generated models uncover therapeutic vulnerabilities of del(11q) CLL cells to dual BCR and PARP inhibition by Quijada-Álamo, Miguel, Hernández-Sánchez, María, Alonso-Pérez, Verónica, Rodríguez-Vicente, Ana E., García-Tuñón, Ignacio, Martín-Izquierdo, Marta, Hernández-Sánchez, Jesús María, Herrero, Ana B., Bastida, José María, San Segundo, Laura, Gruber, Michaela, García, Juan Luis, Yin, Shanye, ten Hacken, Elisa, Benito, Rocío, Ordóñez, José Luis, Wu, Catherine J., Hernández-Rivas, Jesús María

“…The deletion of 11q (del(11q)) invariably comprises ATM gene in chronic lymphocytic leukemia (CLL). Concomitant mutations in this gene in the remaining allele…”
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Characterization of Human B Cell Hematological Malignancies Using Protein-Based Approaches by Jiménez, Cristina, Garrote-de-Barros, Alba, López-Portugués, Carlos, Hernández-Sánchez, María, Díez, Paula

“…The maturation of B cells is a complex, multi-step process. During B cell differentiation, errors can occur, leading to the emergence of aberrant versions of B…”
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Circulating microbial content in myeloid malignancy patients is associated with disease subtypes and patient outcomes by Woerner, Jakob, Huang, Yidi, Hutter, Stephan, Gurnari, Carmelo, Sánchez, Jesús María Hernández, Wang, Janet, Huang, Yimin, Schnabel, Daniel, Aaby, Michael, Xu, Wanying, Thorat, Vedant, Jiang, Dongxu, Jha, Babal K., Koyuturk, Mehmet, Maciejewski, Jaroslaw P., Haferlach, Torsten, LaFramboise, Thomas

“…Although recent work has described the microbiome in solid tumors, microbial content in hematological malignancies is not well-characterized. Here we analyze…”
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High throughput single-cell detection of multiplex CRISPR-edited gene modifications by Ten Hacken, Elisa, Clement, Kendell, Li, Shuqiang, Hernández-Sánchez, María, Redd, Robert, Wang, Shu, Ruff, David, Gruber, Michaela, Baranowski, Kaitlyn, Jacob, Jose, Flynn, James, Jones, Keith W, Neuberg, Donna, Livak, Kenneth J, Pinello, Luca, Wu, Catherine J

“…CRISPR-Cas9 gene editing has transformed our ability to rapidly interrogate the functional impact of somatic mutations in human cancers. Droplet-based…”
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TRAF3 alterations are frequent in del‐3′IGH chronic lymphocytic leukemia patients and define a specific subgroup with adverse clinical features by Pérez‐Carretero, Claudia, Hernández‐Sánchez, María, González, Teresa, Quijada‐Álamo, Miguel, Martín‐Izquierdo, Marta, Santos‐Mínguez, Sandra, Miguel‐García, Cristina, Vidal, María‐Jesús, García‐De‐Coca, Alfonso, Galende, Josefina, Pardal, Emilia, Aguilar, Carlos, Vargas‐Pabón, Manuel, Dávila, Julio, Gascón‐Y‐Marín, Isabel, Hernández‐Rivas, José‐Ángel, Benito, Rocío, Hernández‐Rivas, Jesús‐María, Rodríguez‐Vicente, Ana‐Eugenia

“…Interstitial 14q32 deletions involving IGH gene are infrequent events in chronic lymphocytic leukemia (CLL), affecting less than 5% of patients. To date,…”
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Psychological factors associated with sleep disorders in patients with axial spondyloarthritis or psoriatic arthritis: A multicenter cross‐sectional observational study by Cano‐García, Laura, Mena‐Vázquez, Natalia, Manrique Arija, Sara, Hernández‐Sánchez, María Dolores, Segura‐Ruiz, Rocío, Domínguez‐Quesada, Carmen, Fernández‐Nebro, Antonio

“…Background Studies in axial spondyloarthritis (AxSp) have shown that intensity of pain, anxiety, depression and inflammatory activity are associated with poor…”
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The furosemide stress test and computational modeling identify renal damage sites associated with predisposition to acute kidney injury in rats by Casanova, Alfredo G., Fuentes-Calvo, Isabel, Hernández-Sánchez, María T., Quintero, Miguel, Toral, Paula, Caballero, María T., Martínez-Salgado, Carlos, Morales, Ana I., Layton, Anita T., Eleno, Nélida, López-Hernández, Francisco J.

“…Acute kidney injury (AKI) diagnosis relies on plasma creatinine concentration (Crpl), a relatively insensitive, surrogate biomarker of glomerular filtration…”
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Next-generation sequencing and FISH studies reveal the appearance of gene mutations and chromosomal abnormalities in hematopoietic progenitors in chronic lymphocytic leukemia by Quijada-Álamo, Miguel, Hernández-Sánchez, María, Robledo, Cristina, Hernández-Sánchez, Jesús-María, Benito, Rocío, Montaño, Adrián, Rodríguez-Vicente, Ana E, Quwaider, Dalia, Martín, Ana-África, García-Álvarez, María, Vidal-Manceñido, María Jesús, Ferrer-Garrido, Gonzalo, Delgado-Beltrán, María-Pilar, Galende, Josefina, Rodríguez, Juan-Nicolás, Martín-Núñez, Guillermo, Alonso, José-María, García de Coca, Alfonso, Queizán, José A, Sierra, Magdalena, Aguilar, Carlos, Kohlmann, Alexander, Hernández, José-Ángel, González, Marcos, Hernández-Rivas, Jesús-María

“…Chronic lymphocytic leukemia (CLL) is a highly genetically heterogeneous disease. Although CLL has been traditionally considered as a mature B cell leukemia,…”
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Dissecting the role of TP53 alterations in del(11q) chronic lymphocytic leukemia by Quijada‐Álamo, Miguel, Pérez‐Carretero, Claudia, Hernández‐Sánchez, María, Rodríguez‐Vicente, Ana‐Eugenia, Herrero, Ana‐Belén, Hernández‐Sánchez, Jesús‐María, Martín‐Izquierdo, Marta, Santos‐Mínguez, Sandra, del Rey, Mónica, González, Teresa, Rubio‐Martínez, Araceli, García de Coca, Alfonso, Dávila‐Valls, Julio, Hernández‐Rivas, José‐Ángel, Parker, Helen, Strefford, Jonathan C., Benito, Rocío, Ordóñez, José‐Luis, Hernández‐Rivas, Jesús‐María

“…Background Several genetic alterations have been identified as driver events in chronic lymphocytic leukemia (CLL) pathogenesis and oncogenic evolution…”
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Diabetes and Familial Hypercholesterolemia: Interplay between Lipid and Glucose Metabolism by González-Lleó, Ana M, Sánchez-Hernández, Rosa María, Boronat, Mauro, Wägner, Ana M

“…Familial hypercholesterolemia (FH) is a genetic disease characterized by high low-density lipoprotein (LDL) cholesterol (LDL-c) concentrations that increase…”
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Loss-of-function lesions impact B-cell development and fitness but are insufficient to drive CLL in mouse models by Hacken, Elisa ten, Yin, Shanye, Redd, Robert, Sánchez, María Hernández, Clement, Kendell, Hoffmann, Gabriela Brunsting, Regis, Fara F., Witten, Elizabeth, Li, Shuqiang, Neuberg, Donna, Pinello, Luca, Livak, Kenneth J., Wu, Catherine J.

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Generation of mouse models carrying B cell restricted single or multiplexed loss-of-function mutations through CRISPR-Cas9 gene editing by ten Hacken, Elisa, Gruber, Michaela, Hernández-Sánchez, María, Hoffmann, Gabriela Brunsting, Baranowski, Kaitlyn, Redd, Robert A., Clement, Kendell, Livak, Kenneth, Wu, Catherine J.

“…Here, we present a protocol to generate B cell restricted mouse models of loss-of-function genetic drivers typical of lymphoproliferative disorders, using stem…”
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Splice donor site sgRNAs enhance CRISPR/Cas9-mediated knockout efficiency by García-Tuñón, Ignacio, Alonso-Pérez, Verónica, Vuelta, Elena, Pérez-Ramos, Sandra, Herrero, María, Méndez, Lucía, Hernández-Sánchez, Jesús María, Martín-Izquierdo, Marta, Saldaña, Raquel, Sevilla, Julián, Sánchez-Guijo, Fermín, Hernández-Rivas, Jesús María, Sánchez-Martín, Manuel

“…CRISPR/Cas9 allows the generation of knockout cell lines and null zygotes by inducing site-specific double-stranded breaks. In most cases the DSB is repaired…”
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Characterizing patients with multiple chromosomal aberrations detected by FISH in chronic lymphocytic leukemia by González-Gascón y Marín, Isabel, Hernández-Sanchez, María, Rodríguez-Vicente, Ana Eugenia, Puiggros, Anna, Collado, Rosa, Luño, Elisa, González, Teresa, Ruiz-Xivillé, Neus, Ortega, Margarita, Gimeno, Eva, Muñoz, Carolina, Infante, Maria Stefania, Delgado, Julio, Vargas, María Teresa, González, Marcos, Bosch, Francesc, Espinet, Blanca, Hernández-Rivas, Jesús María, Hernández, José Ángel

“…We analyzed the features of chronic lymphocytic leukemia (CLL) with multiple abnormalities (MA) detected by FISH. A local database including 2095 CLL cases was…”
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Biological significance of monoallelic and biallelic BIRC3 loss in del(11q) chronic lymphocytic leukemia progression by Quijada-Álamo, Miguel, Hernández-Sánchez, María, Rodríguez-Vicente, Ana-Eugenia, Pérez-Carretero, Claudia, Rodríguez-Sánchez, Alberto, Martín-Izquierdo, Marta, Alonso-Pérez, Verónica, García-Tuñón, Ignacio, Bastida, José María, Vidal-Manceñido, María Jesús, Galende, Josefina, Aguilar, Carlos, Queizán, José Antonio, González-Gascón y Marín, Isabel, Hernández-Rivas, José-Ángel, Benito, Rocío, Ordóñez, José Luis, Hernández-Rivas, Jesús-María

“…BIRC3 is monoallelically deleted in up to 80% of chronic lymphocytic leukemia (CLL) cases harboring del(11q). In addition, truncating mutations in the…”
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The presence of genomic imbalances is associated with poor outcome in patients with burkitt lymphoma treated with dose‐intensive chemotherapy including rituximab by Forero‐Castro, Maribel, Robledo, Cristina, Lumbreras, Eva, Benito, Rocio, Hernández‐Sánchez, Jesús M., Hernández‐Sánchez, María, García, Juan L., Corchete‐Sánchez, Luis A., Tormo, Mar, Barba, Pere, Menárguez, Javier, Ribera, Jordi, Grande, Carlos, Escoda, Lourdes, Olivier, Carmen, Carrillo, Estrella, García de Coca, Alfonso, Ribera, Josep‐María, Hernández‐Rivas, Jesús M.

“…Summary The introduction of Rituximab has improved the outcome and survival rates of Burkitt lymphoma (BL). However, early relapse and refractoriness are…”
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The Evolving Landscape of Chronic Lymphocytic Leukemia on Diagnosis, Prognosis and Treatment by Pérez-Carretero, Claudia, González-Gascón-y-Marín, Isabel, Rodríguez-Vicente, Ana E., Quijada-Álamo, Miguel, Hernández-Rivas, José-Ángel, Hernández-Sánchez, María, Hernández-Rivas, Jesús María

“…The knowledge of chronic lymphocytic leukemia (CLL) has progressively deepened during the last forty years. Research activities and clinical studies have been…”
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P846: GENERATION OF A FIRST‐IN‐CLASS INHIBITOR FOR THE MASTER ONCOREGULATOR HNRNP K IN HAEMATOLOGICAL MALIGNANCIES by Otero‐Sobrino, Álvaro, Le Coq, Johanne, Aguilar‐Garrido, Pedro, Aguadero, Miguel Ángel Navarro, Hernández‐Sánchez, María, Isabel Albarrán, María, Klett, Javier, Blanco, Carmen, Fernández Leiro, Rafael, Martinez‐Lopez, Joaquín, Velasco Estevez, Maria, Gallardo, Miguel

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