Search Results - "Hermiston, M. L."

In vivo Analysis of Cadherin Function in the Mouse Intestinal Epithelium: Essential Roles in Adhesion, Maintenance of Differentiation, and Regulation of Programmed Cell Death by Hermiston, Michelle L., Gordon, Jeffrey I.

“…A model system is described for defining the physiologic functions of mammalian cadherins in vivo. 129/Sv embryonic stem (ES) cells, stably transfected with a…”
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Inflammatory Bowel Disease and Adenomas in Mice Expressing a Dominant Negative N-Cadherin by Hermiston, Michelle L., Gordon, Jeffrey I.

“…Cadherins mediate cell adhesion and are essential for normal development. Embryonic stem cells were transfected with a dominant negative N-cadherin mutant…”
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JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias by Delgado-Martin, C, Meyer, L K, Huang, B J, Shimano, K A, Zinter, M S, Nguyen, J V, Smith, G A, Taunton, J, Winter, S S, Roderick, J R, Kelliher, M A, Horton, T M, Wood, B L, Teachey, D T, Hermiston, M L

“…While outcomes for children with T-cell acute lymphoblastic leukemia (T-ALL) have improved dramatically, survival rates for patients with relapsed/refractory…”
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Phenotype of mice lacking functional Deleted in colorectal cancer (Dec) gene by Fazeli, Amin, Dickinson, Stephanie L, Hermiston, Michelle L, Tighe, Robert V, Steen, Robert G, Small, Clayton G, Stoeckli, Esther T, Keino-Masu, Kazuko, Masu, Masayuki, Rayburn, Helen, Simons, Jonathan, Bronson, Roderick T, Gordon, Jeffrey I, Tessier-Lavigne, Marc, Weinberg, Robert A

“…The DCC (Deleted in colorectal cancer) gene was first identified as a candidate for a tumour-suppressor gene on human chromosome 18q. More recently, in vitro…”
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Forced expression of E-cadherin in the mouse intestinal epithelium slows cell migration and provides evidence for nonautonomous regulation of cell fate in a self-renewing system by Hermiston, M L, Wong, M H, Gordon, J I

“…The adult mouse small intestinal epithelium is self-renewing. Its crypt-villus unit provides a model for studying many of the processes that occur during…”
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CD45: A Critical Regulator of Signaling Thresholds in Immune Cells by Hermiston, Michelle L, Xu, Zheng, Weiss, Arthur

“…Regulation of tyrosine phosphorylation is a critical control point for integration of environmental signals into cellular responses. This regulation is…”
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Forced Expression of the Tumor Suppressor Adenomatosis Polyposis Coli Protein Induces Disordered Cell Migration in the Intestinal Epithelium by Wong, Melissa H., Hermiston, Michelle L., Syder, Andrew J., Gordon, Jeffrey I.

“…Mutations of the human adenomatosis polyposis coli (APC) gene are associated with the development of familial as well as sporadic intestinal neoplasia. To…”
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Organization of the crypt-villus axis and evolution of its stem cell hierarchy during intestinal development by Hermiston, M L, Gordon, J I

“…The small intestinal crypt of the adult mouse represents a model system for studying cell renewal. One or more functionally equivalent stem cells located…”
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S255: EFFICACY AND SAFETY OF TISAGENLECLEUCEL IN PEDIATRIC AND YOUNG ADULT PATIENTS (PTS) WITH RELAPSED OR REFRACTORY (R/R) MATURE B‐CELL NON‐HODGKIN LYMPHOMA (NHL): THE PHASE II BIANCA STUDY by Minard‐Colin, V., Buechner, J., Locatelli, F., Gonzalez Martinez, B., Vormoor, B. J., Cooper, S., Krueger, J., Napolitano, S., Attarbaschi, A., Baruchel, A., Ghorashian, S., Hermiston, M. L., Hiramatsu, H., Ifversen, M., John, S., Khaw, S. L., O'Brien, T. A., Phillips, C. L., Diaz de Heredia, C., Tomizawa, D., Vettenranta, K., Wayne, A. S., Newsome, S., Awasthi, R., Redondo, S., Masood, A., Maude, S. L., Burkhardt, B.

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Chimeric-transgenic mice represent a powerful tool for studying how the proliferation and differentiation programs of intestinal epithelial cell lineages are regulated by HERMISTON, M. L, GREEN, R. P, GORDON, J. I

“…An in vivo system has been developed for examining the effects of wild-type or mutant proteins on cell fate determination in the mouse intestinal epithelium or…”
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Use of Transgenic Mice to Infer the Biological Properties of Small Intestinal Stem Cells and to Examine the Lineage Relationships of Their Descendants by Roth, Kevin A., Hermiston, Michelle L., Gordon, Jeffrey I.

“…Transgenes, composed of elements of the 5' nontranscribed region of the liver fatty acid-binding protein (L-FABP) gene linked to various reporters, have…”
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Differentiation and self-renewal in the mouse gastrointestinal epithelium by Gordon, J I, Hermiston, M L

“…The mouse gut epithelium represents a dynamic, geographically well organized, developmental system for examining self-renewal and differentiation. Reagents are…”
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Simultaneous localization of six antigens in single sections of transgenic mouse intestine using a combination of light and fluorescence microscopy by Hermiston, ML, Latham, CB, Gordon, JI, Roth, KA

“…To study the geographic differentiation of the intestinal epithelium and to understand the complex lineage relationships of its cell populations, it is often…”
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Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases by Hermiston, Michelle L, Xu, Zheng, Majeti, Ravindra, Weiss, Arthur

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The Juxtamembrane Wedge Negatively Regulates CD45 Function in B Cells by Hermiston, Michelle L., Tan, Allison L., Gupta, Vikas A., Majeti, Ravindra, Weiss, Arthur

“…CD45 is a receptor-like protein tyrosine phosphatase highly expressed on all nucleated hematopoietic cells. We previously generated mice containing a point…”
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Dysregulation of Signaling Pathways in CD45-Deficient NK Cells Leads to Differentially Regulated Cytotoxicity and Cytokine Production by Hesslein, David G. T., Takaki, Rayna, Hermiston, Michelle L., Weiss, Arthur, Lanier, Lewis L.

“…CD45, a protein tyrosine phosphatase that regulates Src family kinases, is important for regulating T cell and B cell receptor signaling; however, little is…”
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A practical approach to the evaluation of the anemic child by Hermiston, Michelle L, Mentzer, William C

“…Anemia is a sign of disease and not a final diagnosis. The clinician's goal is to define the underlying cause. The anemia may be due to decreased production or…”
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