Search Results - "Hermans, Jos"

Direct electrical quantification of glucose and asparagine from bodily fluids using nanopores by Galenkamp, Nicole Stéphanie, Soskine, Misha, Hermans, Jos, Wloka, Carsten, Maglia, Giovanni

“…Crucial steps in the miniaturisation of biosensors are the conversion of a biological signal into an electrical current as well as the direct sampling of…”
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Development of Lactococcus lactis Biosensors for Detection of Sulfur-Containing Amino Acids by Hernandez-Valdes, Jhonatan A, Dalglish, Maximillian M, Hermans, Jos, Kuipers, Oscar P

“…The sulfur-containing amino acids methionine and cysteine play an important role in food industry. These amino acids are used to confer a sulfur smell or…”
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Quantification of free and total desmosine and isodesmosine in human urine by liquid chromatography tandem mass spectrometry: A comparison of the surrogate-analyte and the surrogate-matrix approach for quantitation by Ongay, Sara, Hendriks, Gert, Hermans, Jos, van den Berge, Maarten, ten Hacken, Nick H.T., van de Merbel, Nico C., Bischoff, Rainer

“…•Synthesis of deuterated- and 18O-labeled DES and IDS standards.•Method development for free and total DES and IDS analysis in human urine.•Full method…”
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Enhancement of amino acid production and secretion by Lactococcus lactis using a droplet-based biosensing and selection system by Hernandez-Valdes, Jhonatan A., aan de Stegge, Myrthe, Hermans, Jos, Teunis, Johan, van Tatenhove-Pel, Rinke J., Teusink, Bas, Bachmann, Herwig, Kuipers, Oscar P.

“…Amino acids are attractive metabolites for the pharmaceutical and food industry field. On one hand, the construction of microbial cell factories for…”
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Regional Centre of Expertise (RCE) Rhine-Meuse: a cross-border network by Rikers, Jos H.A.N, Hermans, Jos H.C.L.M

“…Purpose - The purpose of this paper is to introduce the case of the cross-border RCE Rhine-Meuse established as the first Regional Centre of Expertise (RCE) on…”
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Physicochemical Parameters Affecting the Electrospray Ionization Efficiency of Amino Acids after Acylation by Hermans, Jos, Ongay, Sara, Markov, Vadym, Bischoff, Rainer

“…Electrospray ionization (ESI) is widely used in liquid chromatography coupled to mass spectrometry (LC–MS) for the analysis of biomolecules. However, the ESI…”
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Online coupling of a catalytic continuous microflow reactor to mass spectrometry by Hermans, Jos, Alipour Najmi, Ali, Permentier, Hjalmar, Bischoff, Rainer

“…Flow cell reactors used for catalyst development and applications are upcoming due to their small environmental and economic footprint. Online microflow…”
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Effects of lysine deacetylase inhibitor treatment on LPS responses of alveolar-like macrophages by Russo, Sara, Kwiatkowski, Marcel, Wolters, Justina C, Gerding, Albert, Hermans, Jos, Govorukhina, Natalia, Bischoff, Rainer, Melgert, Barbro N

“…Macrophages are key immune cells that can adapt their metabolic phenotype in response to different stimuli. Lysine deacetylases are important enzymes…”
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Change of charge variant composition of trastuzumab upon stressing at physiological conditions by Spanov, Baubek, Olaleye, Oladapo, Lingg, Nico, Bentlage, Arthur E.H., Govorukhina, Natalia, Hermans, Jos, van de Merbel, Nico, Vidarsson, Gestur, Jungbauer, Alois, Bischoff, Rainer

“…•High-resolution separation of charge variants of the monoclonal antibody trastuzumab by cation-exchange chromatography and elution with pH gradient buffers…”
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Automated Electrical Quantification of Vitamin B1 in a Bodily Fluid using an Engineered Nanopore Sensor by Lucas, Florian Leonardus Rudolfus, Piso, Tjemme Rinze Cornelis, Heide, Nieck Jordy, Galenkamp, Nicole Stéphanie, Hermans, Jos, Wloka, Carsten, Maglia, Giovanni

“…The ability to measure the concentration of metabolites in biological samples is important, both in the clinic and for home diagnostics. Here we present a…”
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Nanoporous Gold Catalyst for the Oxidative N‐Dealkylation of Drug Molecules: A Method for Synthesis of N‐Dealkylated Metabolites by Alipour Najmi, Ali, Jafariyeh‐Yazdi, Elchin, Hadian, Mojgan, Hermans, Jos, Bischoff, Rainer, Yue, Jun, Dömling, Alexander, Wittstock, Arne, Permentier, Hjalmar P.

“…A novel method for the selective catalytic N‐dealkylation of drug molecules on a nanoporous gold (NPG) catalyst producing valuable N‐dealkylated metabolites…”
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A fully validated liquid chromatography-mass spectrometry method for the quantification of the soluble receptor of advanced glycation end-products (sRAGE) in serum using immunopurification in a 96-well plate format by Klont, Frank, Pouwels, Simon D., Hermans, Jos, van de Merbel, Nico C., Horvatovich, Péter, ten Hacken, Nick H.T., Bischoff, Rainer

“…The study of proteins is central to unraveling (patho)physiological processes and has contributed greatly to our understanding of biological systems…”
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Site-specific quantification of lysine acetylation in the N-terminal tail of histone H4 using a double-labelling, targeted UHPLC MS/MS approach by D’Urzo, Annalisa, Boichenko, Alexander P., van den Bosch, Thea, Hermans, Jos, Dekker, Frank, Andrisano, Vincenza, Bischoff, Rainer

“…We developed a targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the site-specific quantification of lysine acetylation in the…”
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A 6-alkylsalicylate histone acetyltransferase inhibitor inhibits histone acetylation and pro-inflammatory gene expression in murine precision-cut lung slices by van den Bosch, Thea, Leus, Niek G.J, Wapenaar, Hannah, Boichenko, Alexander, Hermans, Jos, Bischoff, Rainer, Haisma, Hidde J, Dekker, Frank J

“…Abstract Lysine acetylations are post-translational modifications of cellular proteins, that are crucial in the regulation of many cellular processes. Lysine…”
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Quantitative antibody-free LC–MS/MS analysis of sTRAIL in sputum and saliva at the sub-ng/mL level by Wilffert, Daniel, Donzelli, Riccardo, Asselman, Angela, Hermans, Jos, Govorukhina, Natalia, ten Hacken, Nick H., Quax, Wim J., van de Merbel, Nico C., Bischoff, Rainer

“…•Cytokine sTRAIL was quantified at a ≈3pM (≈200pg/mL) level in saliva and sputum.•A low abundant endogenous protein LC–MS/MS quantification was performed,…”
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Antibody-Free LC-MS/MS Quantification of rhTRAIL in Human and Mouse Serum by Wilffert, Daniel, Reis, Carlos R, Hermans, Jos, Govorukhina, Natalia, Tomar, Tushar, de Jong, Steven, Quax, Wim J, van de Merbel, Nico C, Bischoff, Rainer

“…The major challenge in targeted protein quantification by LC-MS/MS in serum lies in the complexity of the biological matrix with regard to the wide diversity…”
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The relevance of K i calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor by Wapenaar, Hannah, van den Bosch, Thea, Leus, Niek G J, van der Wouden, Petra E, Eleftheriadis, Nikolaos, Hermans, Jos, Hailu, Gebremedhin Solomon, Rotili, Dante, Mai, Antonello, Dömling, Alexander, Bischoff, Rainer, Haisma, Hidde J, Dekker, Frank J

“…Histone acetyltransferases (HATs) are important mediators of epigenetic post-translational modifications of histones that play important roles in health and…”
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The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor by Wapenaar, Hannah, van den Bosch, Thea, Leus, Niek G.J., van der Wouden, Petra E., Eleftheriadis, Nikolaos, Hermans, Jos, Hailu, Gebremedhin Solomon, Rotili, Dante, Mai, Antonello, Dömling, Alexander, Bischoff, Rainer, Haisma, Hidde J., Dekker, Frank J.

“…Histone acetyltransferases (HATs) are important mediators of epigenetic post-translational modifications of histones that play important roles in health and…”
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Automated Electrical Quantification of Vitamin B1 in a Bodily Fluid using an Engineered Nanopore Sensor by Lucas, Florian Leonardus Rudolfus, Piso, Tjemme Rinze Cornelis, Heide, Nieck Jordy, Galenkamp, Nicole Stéphanie, Hermans, Jos, Wloka, Carsten, Maglia, Giovanni

“…The ability to measure the concentration of metabolites in biological samples is important, both in the clinic and for home diagnostics. Here we present a…”
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Highly sensitive antibody-free μLC-MS/MS quantification of rhTRAIL in serum by Wilffert, Daniel, Asselman, Angela, Donzelli, Riccardo, Hermans, Jos, Govorukhina, Natalia, Quax, Wim J, van de Merbel, Nico C, Bischoff, Rainer

“…We describe an antibody-free approach to quantify rhTRAIL (wild-type) and its closely related death receptor 4 selective variant rhTRAIL in human and murine…”
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