Search Results - "Hermann, Dirk"

Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation by Hermann, Dirk M, Prof, Chopp, Michael, Prof

“…Summary Recent laboratory findings suggest that it might be possible to promote cerebral plasticity and neurological recovery after stroke by use of exogenous…”
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Role of sleep-disordered breathing and sleep-wake disturbances for stroke and stroke recovery by Hermann, Dirk M, Bassetti, Claudio L

“…BACKGROUND:Sleep-disordered breathing (SDB) and sleep-wake disturbances (SWD) are highly prevalent in stroke patients. Recent studies suggest that they…”
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Role of glia and extracellular matrix in controlling neuroplasticity in the central nervous system by Dzyubenko, Egor, Hermann, Dirk M.

“…Neuronal plasticity is critical for the maintenance and modulation of brain activity. Emerging evidence indicates that glial cells actively shape…”
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Hot topics in cellular neuropathology III: using CRISPR/Cas9 technology for deciphering central nervous system disease targets by Hermann, Dirk M.

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Extracellular vesicles set the stage for brain plasticity and recovery by multimodal signalling by Hermann, Dirk M, Peruzzotti-Jametti, Luca, Giebel, Bernd, Pluchino, Stefano

“…Extracellular vesicles (EVs) are extremely versatile naturally occurring membrane particles that convey complex signals between cells. EVs of different…”
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Role of Neutrophils in Exacerbation of Brain Injury After Focal Cerebral Ischemia in Hyperlipidemic Mice by Herz, Josephine, Sabellek, Pascal, Lane, Thomas E, Gunzer, Matthias, Hermann, Dirk M, Doeppner, Thorsten R

“…BACKGROUND AND PURPOSE—Inflammation-related comorbidities contribute to stroke-induced immune responses and brain damage. We previously showed that…”
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Implications of polymorphonuclear neutrophils for ischemic stroke and intracerebral hemorrhage: Predictive value, pathophysiological consequences and utility as therapeutic target by Hermann, Dirk M., Kleinschnitz, Christoph, Gunzer, Matthias

“…Polymorphonuclear neutrophil granulocytes (PMN) orchestrate the removal of cell debris in ischemic stroke and intracerebral hemorrhage. In both pathologies,…”
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Multicellular Crosstalk Between Exosomes and the Neurovascular Unit After Cerebral Ischemia. Therapeutic Implications by Zagrean, Ana-Maria, Hermann, Dirk M, Opris, Ioan, Zagrean, Leon, Popa-Wagner, Aurel

“…Restorative strategies after stroke are focused on the remodeling of cerebral endothelial cells and brain parenchymal cells. The latter, i.e., neurons, neural…”
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Acute nicotine exposure attenuates neurological deficits, ischemic injury and brain inflammatory responses and restores hippocampal long-term potentiation in ischemic stroke followed by lipopolysaccharide-induced sepsis-like state by Abbaspour, Sonia, Fahanik-Babaei, Javad, Adeli, Soheila, Hermann, Dirk M., Sardari, Maryam

“…Ischemic stroke is followed by an increased susceptibility to bacterial infections, which exacerbate histological stroke outcome, neurological deficits and…”
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The role of small extracellular vesicles in cerebral and myocardial ischemia—Molecular signals, treatment targets, and future clinical translation by Zheng, Xuan, Hermann, Dirk M., Bähr, Mathias, Doeppner, Thorsten R.

“…The heart and the brain mutually interact with each other, forming a functional axis that is disturbed under conditions of ischemia. Stem cell‐derived…”
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Hot Topics in Cellular Neuropathology II: Promoting Neuronal Plasticity in the Injured Central Nervous System by Hermann, Dirk M.

“…Photographs of his silver nitrate stainings, which he advanced based on Camillo Golgi's (1843–1926) protocols, are legendary. Besides others, Ramon y Cajal…”
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Thrombomodulin, a Master Switch Controlling Poststroke Microvascular Remodeling and Angiogenesis by Hermann, Dirk M., Kleinschnitz, Christoph

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Polymorphonuclear Neutrophils Play a Decisive Role for Brain Injury and Neurological Recovery Poststroke by Hermann, Dirk M, Gunzer, Matthias

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Colocalization of synapse marker proteins evaluated by STED-microscopy reveals patterns of neuronal synapse distribution in vitro by Dzyubenko, Egor, Rozenberg, Andrey, Hermann, Dirk M., Faissner, Andreas

“…[Display omitted] •A reliable and easy-to-use workflow for synapse density quantification is presented.•The differential distribution of GABAergic and…”
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Extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the TGF-β/Smad2/3 pathway by Zhang, Lin, Wei, Wei, Ai, Xiaoyu, Kilic, Ertugrul, Hermann, Dirk M., Venkataramani, Vivek, Bähr, Mathias, Doeppner, Thorsten R.

“…Systemic transplantation of oxygen−glucose deprivation (OGD)-preconditioned primary microglia enhances neurological recovery in rodent stroke models, albeit…”
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Implications of immune responses for ischemic brain injury and stroke recovery by Hermann, Dirk M., Liesz, Arthur, Dzyubenko, Egor

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Lost in the Translation Trap: Quest for a Research Reporting Culture That More Carefully Weighs Clinical Applicability in Experimental Disease Models by Hermann, Dirk M

“…In many disease areas, specifically in ischemic stroke or neurodegenerative diseases, we do not have any disease-modifying therapies at hand, allowing us to…”
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Ischemic stroke and concomitant gastrointestinal complications- a fatal combination for patient recovery by Tuz, Ali A., Hasenberg, Anja, Hermann, Dirk M., Gunzer, Matthias, Singh, Vikramjeet

“…Stroke is primarily a neurodegenerative disease but can also severely impact the functions of other vital organs and deteriorate disease outcomes. A…”
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Extracellular Vesicles Improve Post‐Stroke Neuroregeneration and Prevent Postischemic Immunosuppression by Doeppner, Thorsten R., Herz, Josephine, Görgens, André, Schlechter, Jana, Ludwig, Anna-Kristin, Radtke, Stefan, de Miroschedji, Kyra, Horn, Peter A., Giebel, Bernd, Hermann, Dirk M.

“…The effects of mesenchymal stem cell (MSC)‐derived extracellular vesicles were compared with those of MSCs i.v. delivered 1, 3, and 5 days or 1 day after focal…”
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Efficacy and safety of intravenous tenecteplase compared to alteplase before mechanical thrombectomy in acute ischemic stroke: a meta-analysis by Wu, Nihong, Doeppner, Thorsten R., Hermann, Dirk M., Gronewold, Janine

“…Background The benefits and risks of tenecteplase (TNK) versus alteplase (ALT) have recently been assessed in acute ischemic stroke (AIS) patients undergoing…”
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