Search Results - "Hermann, B"

Mathematical modeling of tumor-immune cell interactions by Mahlbacher, Grace E., Reihmer, Kara C., Frieboes, Hermann B.

“…•Reviews recent continuum mathematical modeling of tumor-immune cell interactions.•Models have complemented experiments to quantify and predict these…”
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Prediction of lung cancer patient survival via supervised machine learning classification techniques by Lynch, Chip M., Abdollahi, Behnaz, Fuqua, Joshua D., de Carlo, Alexandra R., Bartholomai, James A., Balgemann, Rayeanne N., van Berkel, Victor H., Frieboes, Hermann B.

“…•Compared supervised machine learning algorithms to determine predictive correlation.•The models perform well with low to moderate lung cancer patient survival…”
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A computational model for predicting nanoparticle accumulation in tumor vasculature by Frieboes, Hermann B, Wu, Min, Lowengrub, John, Decuzzi, Paolo, Cristini, Vittorio

“…Vascular targeting of malignant tissues with systemically injected nanoparticles (NPs) holds promise in molecular imaging and anti-angiogenic therapies. Here,…”
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Pharmacokinetic/Pharmacodynamics Modeling of Drug-Loaded PLGA Nanoparticles Targeting Heterogeneously Vascularized Tumor Tissue by Miller, Hunter A., Frieboes, Hermann B.

“…Purpose Nanoparticle-mediated drug delivery and efficacy for cancer applications depends on systemic as well as local microenvironment characteristics. Here, a…”
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Advancing cancer immunotherapy: from innovative preclinical models to clinical insights by Craig, Andrew W., Frieboes, Hermann B., Videira, Paula A.

“…The rapid expansion of cancer immunology and immunotherapy builds upon the success of early immune checkpoint inhibitors (ICI) and chimeric antigen receptor T…”
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Rising role of 3D-printing in delivery of therapeutics for infectious disease by Kyser, Anthony J., Fotouh, Bassam, Mahmoud, Mohamed Y., Frieboes, Hermann B.

“…Modern drug delivery to tackle infectious disease has drawn close to personalizing medicine for specific patient populations. Challenges include…”
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CA125 as a predictor of endometrial cancer lymphovascular space invasion and lymph node metastasis for risk stratification in the preoperative setting by Shawn LyBarger, K., Miller, Hunter A., Frieboes, Hermann B.

“…Endometrial cancer (EC) is the most common malignancy of the female reproductive system. Cancer antigen 125 (CA125) is a serum tumor marker widely reported in…”
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Evaluation of innate and adaptive immune system interactions in the tumor microenvironment via a 3D continuum model by Goodin, Dylan A., Frieboes, Hermann B.

“…•Develops 3D continuum mixture model to simulate multiple immune species in the TME.•Includes a variety of cell species from the innate and adaptive immune…”
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Modeling of Tumor Growth with Input from Patient-Specific Metabolomic Data by Miller, Hunter A., Lowengrub, John, Frieboes, Hermann B.

“…Advances in omic technologies have provided insight into cancer progression and treatment response. However, the nonlinear characteristics of cancer growth…”
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To compost or not to compost: Carbon and energy footprints of biodegradable materials’ waste treatment by Hermann, B.G., Debeer, L., De Wilde, B., Blok, K., Patel, M.K.

“…Many life cycle assessments of bio-based and biodegradable materials neglect the post-consumer waste treatment phase because of a lack of consistent data, even…”
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Application of unsupervised analysis techniques to lung cancer patient data by Lynch, Chip M, van Berkel, Victor H, Frieboes, Hermann B

“…This study applies unsupervised machine learning techniques for classification and clustering to a collection of descriptive variables from 10,442 lung cancer…”
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Producing Bio-Based Bulk Chemicals Using Industrial Biotechnology Saves Energy and Combats Climate Change by Hermann, B. G, Blok, K, Patel, M. K

“…The production of bulk chemicals from biomass can make a significant contribution to solving two of the most urgent environmental problems:  climate change and…”
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Mathematical modeling of tumor-associated macrophage interactions with the cancer microenvironment by Mahlbacher, Grace, Curtis, Louis T, Lowengrub, John, Frieboes, Hermann B

“…Immuno-oncotherapy has emerged as a promising means to target cancer. In particular, therapeutic manipulation of tumor-associated macrophages holds promise due…”
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Evaluation of stacked ensemble model performance to predict clinical outcomes: A COVID-19 study by Kablan, Rianne, Miller, Hunter A., Suliman, Sally, Frieboes, Hermann B.

“…•Ensemble machine learning (ML) has garnered attention to predict clinical outcomes.•This study evaluates ensemble model combinations for strong predictive…”
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Modeling of tumor response to macrophage and T lymphocyte interactions in the liver metastatic microenvironment by Curtis, Louis T., Sebens, Susanne, Frieboes, Hermann B.

“…The dynamic interactions between macrophages and T-lymphocytes in the tumor microenvironment exert both antagonistic and synergistic functions affecting tumor…”
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Multi-objective optimization of tumor response to drug release from vasculature-bound nanoparticles by Chamseddine, Ibrahim M., Frieboes, Hermann B., Kokkolaras, Michael

“…The pharmacokinetics of nanoparticle-borne drugs targeting tumors depends critically on nanoparticle design. Empirical approaches to evaluate such designs in…”
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Release kinetics of paclitaxel and cisplatin from two and three layered gold nanoparticles by England, Christopher G., Miller, M. Clarke, Kuttan, Ashani, Trent, John O., Frieboes, Hermann B.

“…[Display omitted] •The drug release of Hydrophilic and hydrophobic was assessed from layered Au nanoparticles.•Layers were – thiol/phosphatidylcholine, or both…”
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Pulmonary Fibrosis Diagnosis and Disease Progression Detected Via Hair Metabolome Analysis by Miller, Hunter A., Suliman, Sally, Frieboes, Hermann B.

“…Background Fibrotic interstitial lung disease is often identified late due to non-specific symptoms, inadequate access to specialist care, and clinical…”
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Computational Modeling of Tumor Response to Drug Release from Vasculature-Bound Nanoparticles by Curtis, Louis T, Wu, Min, Lowengrub, John, Decuzzi, Paolo, Frieboes, Hermann B

“…Systemically injected nanoparticle (NPs) targeting tumor vasculature offer a venue for anti-angiogenic therapies as well as cancer detection and imaging…”
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Multiple breast cancer liver metastases response to macrophage‐delivered nanotherapy evaluated via a 3D continuum model by Goodin, Dylan A., Chau, Eric, Tiwari, Anjana, Godin, Biana, Frieboes, Hermann B.

“…Breast cancer liver metastases (BCLM) are usually unresectable and difficult to treat with systemic chemotherapy. A major reason for chemotherapy failure is…”
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