Search Results - "Herman, Rob"

An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism by Ptacin, Jerod L., Caffaro, Carolina E., Ma, Lina, San Jose Gall, Kristine M., Aerni, Hans R., Acuff, Nicole V., Herman, Rob W., Pavlova, Yelena, Pena, Michael J., Chen, David B., Koriazova, Lilia K., Shawver, Laura K., Joseph, Ingrid B., Milla, Marcos E.

“…The implementation of applied engineering principles to create synthetic biological systems promises to revolutionize medicine, but application of…”
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Plasmodium pyruvate dehydrogenase activity is only essential for the parasite's progression from liver infection to blood infection by Pei, Ying, Tarun, Alice S, Vaughan, Ashley M, Herman, Rob W, Soliman, Joanne M.B, Erickson-Wayman, Alyssa, Kappe, Stefan H.I

“…Plasmodium parasites possess a single pyruvate dehydrogenase (PDH) enzyme complex that is localized to the plastid-like organelle known as the apicoplast…”
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A Precision Engineered Interleukin-2 for Bolstering CD8+ T- and NK-cell Activity without Eosinophilia and Vascular Leak Syndrome in Nonhuman Primates by Ma, Lina, Acuff, Nicole V., Joseph, Ingrid B., Ptacin, Jerod L., Caffaro, Carolina E., San Jose, Kristine M., Aerni, Hans R., Carrio, Roberto, Byers, Anthony M., Herman, Rob W., Pavlova, Yelena, Pena, Michael J., Chen, David B., Buetz, Christen, Ismaili, Taylor K., Pham, Helene V., Cucchetti, Margot, Sassoon, Ingrid, Koriazova, Lilia K., Leveque, Joseph A., Shawver, Laura K., Mooney, Jill M., Milla, Marcos E.

“…We have created a precisely pegylated IL-2 [SAR-444245 (SAR'245) or pegenzileukin, previously THOR-707] designed for proliferation of target CD8+ T and NK…”
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A CD25-biased interleukin-2 for autoimmune therapy engineered via a semi-synthetic organism by Ptacin, Jerod L., Ma, Lina, Caffaro, Carolina E., Acuff, Nicole V., Germar, Kristine, Severy, Peter, Qu, Yanyan, Vela, Jose-Luis, Cai, Xinming, San Jose, Kristine M., Aerni, Hans R., Chen, David B., Esche, Ean, Ismaili, Taylor K., Herman, Rob, Pavlova, Yelena, Pena, Michael J., Nguyen, Jasmine, Koriazova, Lilia K., Shawver, Laura K., Joseph, Ingrid B., Mooney, Jill, Peakman, Mark, Milla, Marcos E.

“…Background Natural cytokines are poorly suited as therapeutics for systemic administration due to suboptimal pharmacological and pharmacokinetic (PK)…”
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A precision engineered interleukin-2 (IL-2) for bolstering CD8+ T- and NK-cell activity without eosinophilia and vascular leak syndrome in non-human primates by Ma, Lina, Acuff, Nicole V, Joseph, Ingrid B, Ptacin, Jerod L, Caffaro, Carolina E, San Jose, Kristine M, Aerni, Hans R, Carrio, Roberto, Byers, Anthony M, Herman, Rob W, Pavlova, Yelena, Pena, Michael J, Chen, David B, Buetz, Christen, Ismaili, Taylor K, Pham, Helene V, Cucchetti, Margot, Sassoon, Ingrid, Koriazova, Lilia K, Leveque, Joseph A, Shawver, Laura K, Mooney, Jill M, Milla, Marcos E

“…We have created a precisely pegylated IL-2 [SAR-444245 (SAR'245) or pegenzileukin, previously THOR- 707] designed for proliferation of target CD8+ T and NK…”
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Small molecule inhibitors of glycosaminoglycan biosynthesis as substrate optimization therapy for the mucopolysaccharidoses by Brown, Jillian R., Herman, Rob W., Webster, Katherine A., Bhagwat, Shripad S., Crawford, Brett E.

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2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections by Tasdemir, Deniz, Sanabria, David, Lauinger, Ina L., Tarun, Alice, Herman, Rob, Perozzo, Remo, Zloh, Mire, Kappe, Stefan H., Brun, Reto, Carballeira, Néstor M.

“…2-, 5-, 6-, and 9-hexadecynoic acids (HDAs) were synthesized and evaluated in vitro against various parasitic protozoa. 2-HDA inhibited both liver and blood…”
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2-Hexadecynoic Acid Inhibits Plasmodial FAS-II Enzymes and Arrest Erythrocytic and Liver Stage Plasmodium Infections by Tasdemir, Deniz, Sanabria, David, Lauinger, Ina L., Tarun, Alice, Herman, Rob, Perozzo, Remo, Zloh, Mire, Kappe, Stefan H., Brun, Reto, Carballeira, Néstor M.

“…Acetylenic fatty acids are known to display several biological activities, but their antimalarial activity has remained unexplored. In this study, we…”
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Cystic rheumatoid arthritis: description of a nonerosive form by Gubler, F M, Maas, M, Dijkstra, P F, de Jongh, H R

“…In a study of patients with rheumatoid arthritis (RA), 9% (n = 70) were found to have a cystic form. At radiologic examination of these patients with cystic…”
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