Search Results - "Herman, Raphael"
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Intraoral wear of PICN CAD-CAM composite restorations used in severe tooth wear treatment: 5-year results of a prospective clinical study using 3D profilometry
Published in Dental materials (01-07-2024)“…To evaluate, in a prospective clinical study over 5 years with ex vivo 3D profilometry analyses, the intraoral wear of Polymer-Infiltrated Ceramic Network…”
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Do all ceramic and composite CAD-CAM materials exhibit equal bonding properties to implant Ti-base materials? An Interfacial Fracture Toughness Study
Published in Dental materials (01-10-2024)“…To compare the interfacial fracture toughness (IFT) with or without aging, of four different classes of CAD-CAM ceramic and composite materials bonded with…”
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The crystal structure of the cell division amidase AmiC reveals the fold of the AMIN domain, a new peptidoglycan binding domain
Published in Molecular microbiology (01-10-2013)“…Summary Binary fission is the ultimate step of the prokaryotic cell cycle. In Gram‐negative bacteria like Escherichia coli, this step implies the invagination…”
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Structure and Function of BcpE2, the Most Promiscuous GH3-Family Glucose Scavenging Beta-Glucosidase
Published in mBio (01-08-2022)“…Cellulose being the most abundant polysaccharide on earth, beta-glucosidases hydrolyzing cello-oligosaccharides are key enzymes to fuel glycolysis in…”
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Crystal structure and activity of Bacillus subtilis YoaJ (EXLX1), a bacterial expansin that promotes root colonization
Published in Proceedings of the National Academy of Sciences - PNAS (04-11-2008)“…We solved the crystal structure of a secreted protein, EXLX1, encoded by the yoaJ gene of Bacillus subtilis. Its structure is remarkably similar to that of…”
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Crystal structure of penicillin-binding protein 3 (PBP3) from Escherichia coli
Published in PloS one (29-05-2014)“…In Escherichia coli, penicillin-binding protein 3 (PBP3), also known as FtsI, is a central component of the divisome, catalyzing cross-linking of the cell wall…”
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Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity
Published in Scientific reports (11-11-2020)“…The Ananas comosus stem extract is a complex mixture containing various cysteine proteases of the C1A subfamily, such as bromelain and ananain. This mixture…”
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Crystal structure and kinetic analysis of the class B3 di-zinc metallo-β-lactamase LRA-12 from an Alaskan soil metagenome
Published in PloS one (01-07-2017)“…We analyzed the kinetic properties of the metagenomic class B3 β-lactamase LRA-12, and determined its crystallographic structure in order to compare it with…”
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Characterisation of the structural, dynamic and aggregation properties of the W64R amyloidogenic variant of human lysozyme
Published in Biophysical chemistry (01-04-2021)“…The accumulation in vital organs of amyloid fibrils made of mutational variants of lysozyme (HuL) is associated with a human systemic amyloid disease. The…”
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Biochemical and structural characterization of a mannose binding jacalin-related lectin with two-sugar binding sites from pineapple (Ananas comosus) stem
Published in Scientific reports (31-07-2018)“…A mannose binding jacalin-related lectin from Ananas comosus stem (AcmJRL) was purified and biochemically characterized. This lectin is homogeneous according…”
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Structural and Kinetic Insights into the “Ceftazidimase” Behavior of the Extended-Spectrum β‑Lactamase CTX-M-96
Published in Biochemistry (Easton) (18-08-2015)“…Diversification of the CTX-M β-lactamases led to the emergence of variants responsible for decreased susceptibility to ceftazidime, like the…”
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Crystal structure of the extended-spectrum β-lactamase PER-2 and insights into the role of specific residues in the interaction with β-lactams and β-lactamase inhibitors
Published in Antimicrobial agents and chemotherapy (01-10-2014)“…PER-2 belongs to a small (7 members to date) group of extended-spectrum β-lactamases. It has 88% amino acid identity with PER-1 and both display high catalytic…”
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The bacterial cell division protein fragment (E)FtsN binds to and activates the major peptidoglycan synthase PBP1b
Published 25-12-2020“…Peptidoglycan (PG) is an essential constituent of the bacterial cell wall. During cell division, the machinery responsible for PG synthesis localizes mid-cell,…”
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Structural Basis for the Interaction of Lactivicins with Serine β-Lactamases
Published in Journal of medicinal chemistry (12-08-2010)“…Lactivicin (LTV) is a natural non-β-lactam antibiotic that inhibits penicillin-binding proteins and serine β-lactamases. A crystal structure of a BS3−LTV…”
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Specific Structural Features of the N-Acetylmuramoyl- l-Alanine Amidase AmiD from Escherichia coli and Mechanistic Implications for Enzymes of This Family
Published in Journal of molecular biology (19-03-2010)“…AmiD is the fifth identified N-acetylmuramoyl- l-alanine zinc amidase of Escherichia coli. This periplasmic lipoprotein is anchored in the outer membrane and…”
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The bacterial cell division protein fragment EFtsN binds to and activates the major peptidoglycan synthase PBP1b
Published in The Journal of biological chemistry (25-12-2020)“…Peptidoglycan (PG) is an essential constituent of the bacterial cell wall. During cell division, the machinery responsible for PG synthesis localizes mid-cell,…”
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Unexpected Tricovalent Binding Mode of Boronic Acids within the Active Site of a Penicillin-Binding Protein
Published in Journal of the American Chemical Society (20-07-2011)“…Boronic acids bearing appropriate side chains are good inhibitors of serine amidohydrolases. The boron usually adopts a tetrahedral conformation, bound to the…”
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Inhibition of dd-Peptidases by a Specific Trifluoroketone: Crystal Structure of a Complex with the Actinomadura R39 dd-Peptidase
Published in Biochemistry (Easton) (26-03-2013)“…Inhibitors of bacterial dd-peptidases represent potential antibiotics. In the search for alternatives to β-lactams, we have investigated a series of compounds…”
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Novel fragments of clavulanate observed in the structure of the class A β-lactamase from Bacillus licheniformis BS3
Published in Journal of antimicrobial chemotherapy (01-10-2012)“…Our aim was to unravel the inactivation pathway of the class A β-lactamase produced by Bacillus licheniformis BS3 (BS3) by clavulanate. The interaction between…”
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Structural determinants of specificity and catalytic mechanism in mammalian 25-kDa thiamine triphosphatase
Published in Biochimica et biophysica acta (01-10-2013)“…Thiamine triphosphate (ThTP) is present in most organisms and might be involved in intracellular signaling. In mammalian cells, the cytosolic ThTP level is…”
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