Search Results - "Herman, James G."

Analysis of DNA methylation in cancer: location revisited by Koch, Alexander, Joosten, Sophie C., Feng, Zheng, de Ruijter, Tim C., Draht, Muriel X., Melotte, Veerle, Smits, Kim M., Veeck, Jurgen, Herman, James G., Van Neste, Leander, Van Criekinge, Wim, De Meyer, Tim, van Engeland, Manon

“…Changes in DNA methylation in cancer have been heralded as promising targets for the development of powerful diagnostic, prognostic, and predictive biomarkers…”
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Epigenetic heterogeneity in cancer by Guo, Mingzhou, Peng, Yaojun, Gao, Aiai, Du, Chen, Herman, James G

“…Abstract Phenotypic and functional heterogeneity is one of the hallmarks of human cancers. Tumor genotype variations among tumors within different patients are…”
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Early Detection of Lung Cancer Using DNA Promoter Hypermethylation in Plasma and Sputum by Hulbert, Alicia, Jusue-Torres, Ignacio, Stark, Alejandro, Chen, Chen, Rodgers, Kristen, Lee, Beverly, Griffin, Candace, Yang, Andrew, Huang, Peng, Wrangle, John, Belinsky, Steven A, Wang, Tza-Huei, Yang, Stephen C, Baylin, Stephen B, Brock, Malcolm V, Herman, James G

“…CT screening can reduce death from lung cancer. We sought to improve the diagnostic accuracy of lung cancer screening using ultrasensitive methods and a lung…”
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Methylation of NRN1 is a novel synthetic lethal marker of PI3K‐Akt‐mTOR and ATR inhibitors in esophageal cancer by Du, Wushuang, Gao, Aiai, Herman, James G., Wang, Lidong, Zhang, Lirong, Jiao, Shunchang, Guo, Mingzhou

“…Wnt, PI3K‐Akt‐mTOR, and NF‐κB pathways were reported to be involved in DNA damage repair (DDR). DDR‐deficient cancers become critically dependent on backup DNA…”
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Colorectal Cancer Epigenetics: Complex Simplicity by VAN ENGELAND, Manon, DERKS, Sarah, SMITS, Kim M, MEIJER, GerritA, HERMAN, James G

“…Colorectal cancer (CRC) has predominantly been considered a genetic disease, characterized by sequential accumulation of genetic alterations. Growing evidence…”
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DNA-methylation for the detection and distinction of 19 human malignancies by Danilova, Ludmila, Wrangle, John, Herman, James G., Cope, Leslie

“…The contribution of DNA-methylation based gene silencing to carcinogenesis is well established. Increasingly, DNA-methylation is examined using genome-wide…”
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BRCA1 CpG island hypermethylation predicts sensitivity to poly(adenosine diphosphate)-ribose polymerase inhibitors by Veeck, Jurgen, Ropero, Santiago, Setien, Fernando, Gonzalez-Suarez, Eva, Osorio, Ana, Benitez, Javier, Herman, James G, Esteller, Manel

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Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer by Singh, Anju, Misra, Vikas, Thimmulappa, Rajesh K, Lee, Hannah, Ames, Stephen, Hoque, Mohammad O, Herman, James G, Baylin, Stephen B, Sidransky, David, Gabrielson, Edward, Brock, Malcolm V, Biswal, Shyam

“…Nuclear factor erythroid-2 related factor 2 (NRF2) is a redox-sensitive transcription factor that positively regulates the expression of genes encoding…”
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GPX3 promoter methylation predicts platinum sensitivity in colorectal cancer by Pelosof, Lorraine, Yerram, Sashidhar, Armstrong, Todd, Chu, Nina, Danilova, Ludmila, Yanagisawa, Breann, Hidalgo, Manuel, Azad, Nilofer, Herman, James G.

“…Epigenetic control of gene expression is a major determinant of tumor phenotype and has been found to influence sensitivity to individual chemotherapeutic…”
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DNA Methylation Markers and Early Recurrence in Stage I Lung Cancer by Brock, Malcolm V, Hooker, Craig M, Ota-Machida, Emi, Han, Yu, Guo, Mingzhou, Ames, Stephen, Glöckner, Sabine, Piantadosi, Steven, Gabrielson, Edward, Pridham, Genevieve, Pelosky, Kristen, Belinsky, Steven A, Yang, Stephen C, Baylin, Stephen B, Herman, James G

“…Methylation of the promoter region of a gene is a mechanism that influences gene expression. In this study of patients with stage I non–small-cell lung cancer…”
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The CpG Island Methylator Phenotype: What's in a Name? by HUGHES, Laura A. E, MELOTTE, Veerle, VAN CRIEKINGE, Wim, AHUJA, Nita, HERMAN, James G, WEIJENBERG, Matty P, VAN ENGELAND, Manon, DE SCHRIJVER, Joachim, DE MAAT, Michiel, SMIT, Vincent T. H. B. M, BOVEE, Judith V. M. G, FRENCH, Pim J, VAN DEN BRANDT, Piet A, SCHOUTEN, Leo J, DE MEYER, Tim

“…Although the CpG island methylator phenotype (CIMP) was first identified and has been most extensively studied in colorectal cancer, the term "CIMP" has been…”
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Epigenetic silencing of JAM3 promotes esophageal cancer development by activating Wnt signaling by Yang, Weili, Guo, Chao, Herman, James G, Zhu, Cheng, Lv, Honghui, Su, Xiaomo, Zhang, Lirong, Zhang, Meiying, Guo, Mingzhou

“…The role of JAM3 in different tumors is controversial. The epigenetic regulation and the mechanism of JAM3 remain to be elucidated in human esophageal cancer…”
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Novel Methylation Biomarker Panel for the Early Detection of Pancreatic Cancer by JOO MI YI, GUZZETTA, Angela A, PAPPOU, Emmanouil P, LACOBUZIO-DONAHUE, Christine A, GOGGINS, Michael G, HERMAN, James G, WANG, Tza-Huei, BAYLIN, Stephen B, AHUJA, Nita, BAILEY, Vasudev J, DOWNING, Stephanie R, VAN NESTE, Leander, CHIAPPINELLI, Katherine B, KEELEY, Brian P, STARK, Alejandro, HERRERA, Alexander, WOLFGANG, Christopher

“…Pancreatic cancer is the fourth leading cause of cancer deaths and there currently is no reliable modality for the early detection of this disease. Here, we…”
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Caveolin-1 promotes the tumor suppressor properties of oncogene-induced cellular senescence by Volonte, Daniela, Vyas, Avani R., Chen, Chen, Dacic, Sanja, Stabile, Laura P., Kurland, Brenda F., Abberbock, Shira R., Burns, Timothy F., Herman, James G., Di, Yuanpu Peter, Galbiati, Ferruccio

“…Oncogene-induced senescence (OIS) is considered a powerful tumor suppressor mechanism. Caveolin-1 acts as a scaffolding protein to functionally regulate…”
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The Epigenetic promise for prostate cancer diagnosis by Van Neste, Leander, Herman, James G, Otto, Gaëtan, Bigley, Joseph W, Epstein, Jonathan I, Van Criekinge, Wim

“…BACKGROUND Prostate cancer is the most common cancer diagnosis in men and a leading cause of death. Improvements in disease management would have a significant…”
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Predictive value of CHFR and MLH1 methylation in human gastric cancer by Li, Yazhuo, Yang, Yunsheng, Lu, Youyong, Herman, James G., Brock, Malcolm V., Zhao, Po, Guo, Mingzhou

“…Background Gastric carcinoma (GC) has one of the highest mortality rates of cancer diseases and has a high incidence rate in China. Palliative chemotherapy is…”
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DREAMing: a simple and ultrasensitive method for assessing intratumor epigenetic heterogeneity directly from liquid biopsies by Pisanic, 2nd, Thomas R, Athamanolap, Pornpat, Poh, Weijie, Chen, Chen, Hulbert, Alicia, Brock, Malcolm V, Herman, James G, Wang, Tza-Huei

“…Many cancers comprise heterogeneous populations of cells at primary and metastatic sites throughout the body. The presence or emergence of distinct subclones…”
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Neighborhood-level deprivation and survival in lung cancer by Kennedy, Kathleen, Jusue-Torres, Ignacio, Buller, Ian D, Rossi, Emily, Mallisetty, Apurva, Rodgers, Kristen, Lee, Beverly, Menchaca, Martha, Pasquinelli, Mary, Nguyen, Ryan H, Weinberg, Frank, Rubinstein, Israel, Herman, James G, Brock, Malcolm, Feldman, Lawrence, Aldrich, Melinda C, Hulbert, Alicia

“…Despite recent advances in lung cancer therapeutics and improving overall survival, disparities persist among socially disadvantaged populations. This study…”
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Silencing NKD2 by Promoter Region Hypermethylation Promotes Esophageal Cancer Progression by Activating Wnt Signaling by Cao, Baoping, Yang, Weili, Jin, Yongshuai, Zhang, Meiying, He, Tao, Zhan, Qimin, Herman, James G, Zhong, Guanglin, Guo, Mingzhou

“…Naked cuticle homolog 2 (NKD2) was found to be frequently methylated in human breast and gastric cancers. However, the epigenetic changes and mechanisms of…”
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hTERT is expressed in cancer cell lines despite promoter DNA methylation by preservation of unmethylated DNA and active chromatin around the transcription start site by ZINN, Rebekah L, PRUITT, Kevin, EGUCHI, Sayaka, BAYLIN, Stephen B, HERMAN, James G

“…hTERT, which encodes the catalytic subunit of telomerase and is expressed in most immortalized and cancer cells, has been reported to have increased DNA…”
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