Search Results - "Herman, Ann"

Inhibition of DYRK1A and GSK3B induces human β-cell proliferation by Shen, Weijun, Taylor, Brandon, Jin, Qihui, Nguyen-Tran, Van, Meeusen, Shelly, Zhang, You-Qing, Kamireddy, Anwesh, Swafford, Austin, Powers, Andrew F., Walker, John, Lamb, John, Bursalaya, Badry, DiDonato, Michael, Harb, George, Qiu, Minhua, Filippi, Christophe M., Deaton, Lisa, Turk, Carolina N., Suarez-Pinzon, Wilma L., Liu, Yahu, Hao, Xueshi, Mo, Tingting, Yan, Shanshan, Li, Jing, Herman, Ann E., Hering, Bernhard J., Wu, Tom, Martin Seidel, H., McNamara, Peter, Glynne, Richard, Laffitte, Bryan

“…Insufficient pancreatic β-cell mass or function results in diabetes mellitus. While significant progress has been made in regulating insulin secretion from…”
Get full text

Identification of an IL-22-Dependent Gene Signature as a Pharmacodynamic Biomarker by Rae, Julie, Hackney, Jason, Huang, Kevin, Keir, Mary, Herman, Ann

“…Interleukin-22 (IL-22) plays a role in epithelial barrier function and repair, and may provide benefits in conditions like inflammatory bowel disease. However,…”
Get full text

Development of a novel, highly sensitive assay for quantification of minimal residual B cells in autoimmune disease and comparison to traditional methods across B-cell–depleting agents by Looney, Cary M., Strauli, Nicolas, Cascino, Matthew D., Garma, Hailey, Schroeder, Aaron V., Takahashi, Chikara, O'Gorman, William, Green, Cherie, Herman, Ann E.

“…Targeted B-cell depletion is a useful therapy for many diseases, including autoimmune disorders and certain cancers. We developed a sensitive blood B-cell…”
Get full text

Safety, Pharmacokinetics, and Pharmacodynamics in Healthy Volunteers Treated With GDC‐0853, a Selective Reversible Bruton's Tyrosine Kinase Inhibitor by Herman, Ann E., Chinn, Leslie W., Kotwal, Shweta G., Murray, Elaine R., Zhao, Rui, Florero, Marilyn, Lin, Alyse, Moein, Anita, Wang, Rena, Bremer, Meire, Kokubu, Serika, Serone, Adrian P., Hanze, Eva L., Viberg, Anders, Morimoto, Alyssa M., Winter, Helen R., Katsumoto, Tamiko R.

“…GDC‐0853 is a small molecule inhibitor of Bruton's tyrosine kinase (BTK) that is highly selective and noncovalent, leading to reversible binding. In…”
Get full text

Discovery and Qualification of Candidate Urinary Biomarkers of Disease Activity in Lupus Nephritis by Anania, Veronica G, Yu, Kebing, Pingitore, Francesco, Li, Qingling, Rose, Christopher M, Liu, Peter, Sandoval, Wendy, Herman, Ann E, Lill, Jennie R, Mathews, W. Rodney

“…Lupus nephritis (LN) is a severe clinical manifestation of systemic lupus erythematosus (SLE) associated with significant morbidity and mortality. Assessment…”
Get full text

CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion by Herman, Ann E, Freeman, Gordon J, Mathis, Diane, Benoist, Christophe

“…CD4+CD25+ T regulatory cells (Tregs) prevent autoimmune disease, yet little is known about precisely where they exert their influence naturally in a…”
Get full text

Where CD4+CD25+ T reg cells impinge on autoimmune diabetes by Chen, Zhibin, Herman, Ann E, Matos, Michael, Mathis, Diane, Benoist, Christophe

“…Foxp3 is required for the generation and activity of CD4(+)CD25(+) regulatory T (T reg) cells, which are important controllers of autoimmunity, including…”
Get full text

Blood neurofilament light levels predict non-relapsing progression following anti-CD20 therapy in relapsing and primary progressive multiple sclerosis: findings from the ocrelizumab randomised, double-blind phase 3 clinical trials by Bar-Or, Amit, Thanei, Gian-Andrea, Harp, Christopher, Bernasconi, Corrado, Bonati, Ulrike, Cross, Anne H., Fischer, Saloumeh, Gaetano, Laura, Hauser, Stephen L., Hendricks, Robert, Kappos, Ludwig, Kuhle, Jens, Leppert, David, Model, Fabian, Sauter, Annette, Koendgen, Harold, Jia, Xiaoming, Herman, Ann E.

“…Neurofilament light chain (NfL), a neuronal cytoskeletal protein that is released upon neuroaxonal injury, is associated with multiple sclerosis (MS) relapsing…”
Get full text

Genome-wide study of longitudinal brain imaging measures of multiple sclerosis progression across six clinical trials by Loomis, Stephanie J., Sadhu, Nilanjana, Fisher, Elizabeth, Gafson, Arie R., Huang, Yunfeng, Yang, Chengran, Hughes, Emily E., Marshall, Eric, Herman, Ann, John, Sally, Runz, Heiko, Jia, Xiaoming, Bhangale, Tushar, Bronson, Paola G.

“…While the genetics of MS risk susceptibility are well-described, and recent progress has been made on the genetics of disease severity, the genetics of disease…”
Get full text

Inhibition of c-Kit is not required for reversal of hyperglycemia by imatinib in NOD mice by Lau, Janet, Zhou, Qiang, Sutton, Susan E, Herman, Ann E, Schmedt, Christian, Glynne, Richard

“…Recent studies indicate that tyrosine kinase inhibitors, including imatinib, can reverse hyperglycemia in non-obese diabetic (NOD) mice, a model of type 1…”
Get full text

Small-Molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening by Shen, Weijun, Tremblay, Matthew S, Deshmukh, Vishal A, Wang, Weidong, Filippi, Christophe M, Harb, George, Zhang, You-qing, Kamireddy, Anwesh, Baaten, Janine E, Jin, Qihui, Wu, Tom, Swoboda, Jonathan G, Cho, Charles Y, Li, Jing, Laffitte, Bryan A, McNamara, Peter, Glynne, Richard, Wu, Xu, Herman, Ann E, Schultz, Peter G

“…The identification of factors that promote β cell proliferation could ultimately move type 1 diabetes treatment away from insulin injection therapy and toward…”
Get full text

IL-2 immunotherapy reveals potential for innate beta cell regeneration in the non-obese diabetic mouse model of autoimmune diabetes by Diaz-de-Durana, Yaiza, Lau, Janet, Knee, Deborah, Filippi, Christophe, Londei, Marco, McNamara, Peter, Nasoff, Marc, DiDonato, Michael, Glynne, Richard, Herman, Ann E

“…Type-1 diabetes (T1D) is an autoimmune disease targeting insulin-producing beta cells, resulting in dependence on exogenous insulin. To date, significant…”
Get full text

Development of an age‐adjusted model for blood neurofilament light chain by Harp, Christopher, Thanei, Gian‐Andrea, Jia, Xiaoming, Kuhle, Jens, Leppert, David, Schaedelin, Sabine, Benkert, Pascal, Büdingen, H‐Christian, Hendricks, Robert, Herman, Ann

“…Objective To develop an age‐adjustment model for neurofilament light chain (NfL), an emerging injury marker in patients with a range of neurologic conditions…”
Get full text

Efficacy and safety of pateclizumab (anti-lymphotoxin-α) compared to adalimumab in rheumatoid arthritis: a head-to-head phase 2 randomized controlled study (The ALTARA Study) by Kennedy, William P, Simon, J Abraham, Offutt, Carolyn, Horn, Priscilla, Herman, Ann, Townsend, Michael J, Tang, Meina T, Grogan, Jane L, Hsieh, Frank, Davis, John C

“…Tumor necrosis factor (TNF) and, possibly, lymphotoxin alpha (LTα) signaling contribute to inflammation and rheumatoid arthritis (RA) pathogenesis…”
Get full text

Cell-type-specific tonic GABA signaling in the rat central amygdala is selectively altered by acute and chronic ethanol by Herman, Melissa Ann, Roberto, Marisa

“…The central nucleus of the amygdala (CeA) is an important site for the reinforcing effects of ethanol and has been implicated in the development of alcohol…”
Get full text

Effect of Ocrelizumab on B- and T-Cell Receptor Repertoire Diversity in Patients With Relapsing Multiple Sclerosis From the Randomized Phase III OPERA Trial by Laurent, Sarah A, Strauli, Nicolas B, Eggers, Erica L, Wu, Hao, Michel, Brady, Demuth, Stanislas, Palanichamy, Arumugam, Wilson, Michael R, Sirota, Marina, Hernandez, Ryan D, Cree, Bruce Anthony Campbell, Herman, Ann E, von Büdingen, H-Christian

“…The B cell-depleting anti-CD20 antibody ocrelizumab (OCR) effectively reduces MS disease activity and slows disability progression. Given the role of B cells…”
Get full text

Development of an Automated, High-Throughput Bactericidal Assay That Measures Cellular Respiration as a Survival Readout for Neisseria meningitidis by Mak, Puiying A, Santos, George F, Masterman, Kelly-Anne, Janes, Jeff, Wacknov, Bill, Vienken, Kay, Giuliani, Marzia, Herman, Ann E, Cooke, Michael, Mbow, M Lamine, Donnelly, John

“…Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Cathepsin L is essential for onset of autoimmune diabetes in NOD mice by Maehr, René, Mintern, Justine D, Herman, Ann E, Lennon-Duménil, Ana-Maria, Mathis, Diane, Benoist, Christophe, Ploegh, Hidde L

“…Lysosomal proteases generate peptides presented by class II MHC molecules to CD4+ T cells. To determine whether specific lysosomal proteases might influence…”
Get full text

A Conserved Salt Bridge in the G Loop of Multiple Protein Kinases Is Important for Catalysis and for In Vivo Lyn Function by Barouch-Bentov, Rina, Che, Jianwei, Lee, Christian C., Yang, Yating, Herman, Ann, Jia, Yong, Velentza, Anastasia, Watson, James, Sternberg, Luise, Kim, Sunjun, Ziaee, Niusha, Miller, Andrew, Jackson, Carie, Fujimoto, Manabu, Young, Mike, Batalov, Serge, Liu, Yi, Warmuth, Markus, Wiltshire, Tim, Cooke, Michael P., Sauer, Karsten

“…The glycine-rich G loop controls ATP binding and phosphate transfer in protein kinases. Here we show that the functions of Src family and Abl protein tyrosine…”
Get full text

Correction to “Small-Molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening” by Shen, Weijun, Tremblay, Matthew S, Deshmukh, Vishal A, Wang, Weidong, Filippi, Christophe M, Harb, George, Zhang, You-qing, Kamireddy, Anwesh, Baaten, Janine E, Jin, Qihui, Wu, Tom, Swoboda, Jonathan G, Peters, Eric C, Cho, Charles Y, Li, Jing, Laffitte, Bryan A, McNamara, Peter, Glynne, Richard, Wu, Xu, Herman, Ann E, Schultz, Peter G

Get full text