Search Results - "Herman, A G"

Vasodilator efficacy of nitric oxide depends on mechanisms of intracellular calcium mobilization in mouse aortic smooth muscle cells by Van Hove, CE, Van der Donckt, C, Herman, AG, Bult, H, Fransen, P

“…Background and purpose:  Reduction of intracellular calcium ([Ca2+]i) in smooth muscle cells (SMCs) is an important mechanism by which nitric oxide (NO)…”
Get full text

Dipeptidyl Peptidase-4 Inhibitors for the Treatment of Type 2 Diabetes: Focus On Sitagliptin by Herman, G A, Stein, P P, Thornberry, N A, Wagner, J A

“…Dipeptidyl peptidase‐4 (DPP‐4) inhibitors represent a new class of oral antihyperglycemic agents to treat patients with type 2 diabetes.1 DPP‐4 inhibitors…”
Get full text

Potent and Selective Agonism of the Melanocortin Receptor 4 With MK-0493 Does Not Induce Weight Loss in Obese Human Subjects: Energy Intake Predicts Lack of Weight Loss Efficacy by Krishna, R, Gumbiner, B, Stevens, C, Musser, B, Mallick, M, Suryawanshi, S, Maganti, L, Zhu, H, Han, T H, Scherer, L, Simpson, B, Cosgrove, D, Gottesdiener, K, Amatruda, J, Rolls, B J, Blundell, J, Bray, G A, Fujioka, K, Heymsfield, S B, Wagner, J A, Herman, G A

“…MK‐0493 is a novel, potent, and selective agonist of the melanocortin receptor 4 (MC4R), one of the best‐validated genetic targets and considered one of the…”
Get full text

The Impact Of Light Pollution On Bats Varies According To Foraging Guild And Habitat Context by Voigt, Christian C, Dekker, Jasja, Fritze, Marcus, Gazaryan, Suren, Hölker, Franz, Jones, Gareth, Lewanzik, Daniel, Limpens, Herman J G A, Mathews, Fiona, Rydell, Jens, Spoelstra, Kamiel, Zagmajster, Maja

“…Abstract We Review How Different Bat Guilds Respond To Artificial Light At Night (Alan) And Assess How The Impacts Can Vary According To Ecological Context…”
Get full text

Reactive oxygen species induce RNA damage in human atherosclerosis by Martinet, W., De Meyer, G. R. Y., Herman, A. G., Kockx, M. M.

“…Background  Reactive oxygen species (ROS)‐induced DNA damage has recently been identified in both human and experimental atherosclerosis. This study was…”
Get full text

TRPV1 receptors on unmyelinated C-fibres mediate colitis-induced sensitization of pelvic afferent nerve fibres in rats by De Schepper, H. U., De Winter, B. Y., Van Nassauw, L., Timmermans, J.‐P., Herman, A. G., Pelckmans, P. A., De Man, J. G.

“…Patients with inflammatory bowel disease often suffer from gastrointestinal motility and sensitivity disorders. The aim of the current study was to investigate…”
Get full text

Effect of ghrelin and growth hormone‐releasing peptide 6 on septic ileus in mice by De Winter, B. Y., De Man, J. G., Seerden, T. C., Depoortere, I., Herman, A. G., Peeters, T. L., Pelckmans, P. A.

“…Ghrelin is an orexigenic peptide with prokinetic effects in the rat. We investigated the effect of ghrelin and growth hormone‐releasing hormone 6 (GHRP‐6) on…”
Get full text

TRPV1 receptor signaling mediates afferent nerve sensitization during colitis-induced motility disorders in rats by De Schepper, H U, De Man, J G, Ruyssers, N E, Deiteren, A, Van Nassauw, L, Timmermans, J-P, Martinet, W, Herman, A G, Pelckmans, P A, De Winter, B Y

“…Rats with experimental colitis suffer from impaired gastric emptying (GE). We previously showed that this phenomenon involves afferent neurons within the…”
Get more information

Study on the cyclic GMP‐dependency of relaxations to endogenous and exogenous nitric oxide in the mouse gastrointestinal tract by Man, J G, Winter, B Y, Herman, A G, Pelckmans, P A

“…Background and purpose: cGMP mediates nitrergic relaxations of intestinal smooth muscle, but several studies have indicated that cGMP‐independent mechanisms…”
Get full text

Acute distal colitis impairs gastric emptying in rats via an extrinsic neuronal reflex pathway involving the pelvic nerve by De Schepper, H U, De Man, J G, Van Nassauw, L, Timmermans, J-P, Herman, A G, Pelckmans, P A, De Winter, B Y

“…Background and aims: Patients with inflammatory bowel disease often present with abnormal gut motility away from the inflammatory site. We studied remote…”
Get full text

An accessible pharmacodynamic transcriptional biomarker for notch target engagement by Tanis, KQ, Podtelezhnikov, AA, Blackman, SC, Hing, J, Railkar, RA, Lunceford, J, Klappenbach, JA, Wei, B, Harman, A, Camargo, LM, Shah, S, Finney, EM, Hardwick, JS, Loboda, A, Watters, J, Bergstrom, DA, Demuth, T, Herman, GA, Strack, PR, Iannone, R

“…γ‐Secretase mediates amyloid production in Alzheimer's disease (AD) and oncogenic activity of Notch. γ‐Secretase inhibitors (GSIs) are thus of interest for AD…”
Get full text

Concurrent infection with Schistosoma mansoni attenuates inflammation induced changes in colonic morphology, cytokine levels, and smooth muscle contractility of trinitrobenzene sulphonic acid induced colitis in rats by Moreels, T G, Nieuwendijk, R J, De Man, J G, De Winter, B Y, Herman, A G, Van Marck, E A, Pelckmans, P A

“…Background and aims: Crohn’s disease, characterised by chronic T helper 1 (Th1) inflammation and dysmotility of the gut, is most prevalent in developed…”
Get full text

Apoptosis and related proteins in different stages of human atherosclerotic plaques by KOCKX, M. M, DE MEYER, G. R. Y, MUHRING, J, JACOB, W, BULT, H, HERMAN, A. G

“…The transition of a fatty streak into an atherosclerotic plaque is characterized by the appearance of focal and diffuse regions of cell death. We have…”
Get full text

Nitric oxide selectively depletes macrophages in atherosclerotic plaques via induction of endoplasmic reticulum stress by Martinet, W, Croons, V, Timmermans, J‐P, Herman, A G, Meyer, G R Y

“…Background and purpose: Macrophages in atherosclerotic plaques have a tremendous impact on atherogenesis and plaque destabilization. We previously demonstrated…”
Get full text

Apoptosis in atherogenesis : implications for plaque destabilization by KOCKX, M. M, HERMAN, A. G

“…Atherosclerotic plaques in coronary arteries are composed of a crescent-shaped mass of lipids separated from the lumen by a fibrous cap. Loss of smooth muscle…”
Get full text

Nitric oxide as an inhibitory non-adrenergic non-cholinergic neurotransmitter by Bult, H, Boeckxstaens, G. E, Pelckmans, P. A, Jordaens, F. H, Maercke, Y. M. Van, Herman, A. G

“…Inhibitory non-adrenergic non-cholinergic (NANC) nerves are thought to be important in the autonomic innervation of the gastrointestinal tract and other organ…”
Get full text

Oxidative DNA Damage and Repair in Experimental Atherosclerosis Are Reversed by Dietary Lipid Lowering by Martinet, Wim, Knaapen, Michiel W.M, De Meyer, Guido R.Y, Herman, Arnold G, Kockx, Mark M

“…Increased oxidative stress is a major characteristic of hypercholesterolemia-induced atherosclerosis. The oxidative environment is mainly created by the…”
Get full text

Role of oxidative stress in the pathogenesis of septic ileus in mice by De Winter, B. Y., Van Nassauw, L., De Man, J. G., De Jonge, F., Bredenoord, A. J., Seerden, T. C., Herman, A. G., Timmermans, J.‐p., Pelckmans, P. A.

“…We investigated the role of oxidative stress in the pathogenesis of septic ileus. Sepsis was induced by intraperitoneal (i.p.) injection of lipopolysaccharides…”
Get full text

Differential role of tachykinin NK3 receptors on cholinergic excitatory neurotransmission in the mouse stomach and small intestine by De Man, J G, De Winter, B Y, De Schepper, H U, Herman, A G, Pelckmans, P A

“…Background and purpose: Tachykinin NK3 receptors are widely expressed in the mouse gastrointestinal tract but their functional role in enteric neuromuscular…”
Get full text

Effect of different prokinetic agents and a novel enterokinetic agent on postoperative ileus in rats by De Winter, B Y, Boeckxstaens, G E, De Man, J G, Moreels, T G, Schuurkes, J A J, Peeters, T L, Herman, A G, Pelckmans, P A

“…BACKGROUND/AIM The effects of different prokinetic agents, the motilide erythromycin and the substituted benzamides metoclopramide and cisapride, were…”
Get full text