Search Results - "Herlyn, Meenhard M."

Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation by Kim, Hyungsoo, Frederick, Dennie T., Levesque, Mitchell P., Cooper, Zachary A., Feng, Yongmei, Krepler, Clemens, Brill, Laurence, Samuels, Yardena, Hayward, Nicholas K., Perlina, Ally, Piris, Adriano, Zhang, Tongwu, Halaban, Ruth, Herlyn, Meenhard M., Brown, Kevin M., Wargo, Jennifer A., Dummer, Reinhard, Flaherty, Keith T., Ronai, Ze’ev A.

“…Despite the remarkable clinical response of melanoma harboring BRAF mutations to BRAF inhibitors (BRAFi), most tumors become resistant. Here, we identified the…”
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BRAF Inhibitor Unveils Its Potential against Advanced Melanoma by Vultur, Adina, Villanueva, Jessie, Herlyn, Meenhard

“…Unresponsiveness to therapy is a hallmark feature of advanced metastatic melanoma. However, the discovery of BRAF-activating mutations in approximately 50% of…”
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