Search Results - "Hering, B. J."

Advancing islet transplantation: from engraftment to the immune response by Gibly, R. F., Graham, J. G., Luo, X., Lowe, W. L., Hering, B. J., Shea, L. D.

“…The promise and progress of islet transplantation for treating type 1 diabetes has been challenged by obstacles to patient accessibility and long-term graft…”
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Potent Induction Immunotherapy Promotes Long‐Term Insulin Independence After Islet Transplantation in Type 1 Diabetes by Bellin, M. D., Barton, F. B., Heitman, A., Harmon, J. V., Kandaswamy, R., Balamurugan, A. N., Sutherland, D. E. R., Alejandro, R., Hering, B. J.

“…The seemingly inexorable decline in insulin independence after islet transplant alone (ITA) has raised concern about its clinical utility. We hypothesized that…”
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Proposed Thresholds for Pancreatic Tissue Volume for Safe Intraportal Islet Autotransplantation After Total Pancreatectomy by Wilhelm, J. J., Bellin, M. D., Dunn, T. B., Balamurugan, A. N., Pruett, T. L., Radosevich, D. M., Chinnakotla, S., Schwarzenberg, S. J., Freeman, M. L., Hering, B. J., Sutherland, D. E. R., Beilman, G. J.

“…The simple question of how much tissue volume (TV) is really safe to infuse in total pancreatectomy–islet autotransplantation (TP–IAT) for chronic pancreatitis…”
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Dimorphic histopathology of long-standing childhood-onset diabetes by Gianani, R, Campbell-Thompson, M, Sarkar, S. A, Wasserfall, C, Pugliese, A, Solis, J. M, Kent, S. C, Hering, B. J, West, E, Steck, A, Bonner-Weir, S, Atkinson, M. A, Coppieters, K, von Herrath, M, Eisenbarth, G. S

“…Aims/hypothesis Childhood diabetes is thought to usually result from autoimmune beta cell destruction (type 1A) with eventual total loss of beta cells…”
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Human Islet Oxygen Consumption Rate and DNA Measurements Predict Diabetes Reversal in Nude Mice by Papas, K. K., Colton, C. K., Nelson, R. A., Rozak, P. R., Avgoustiniatos, E. S., Scott, W. E., Wildey, G. M., Pisania, A., Weir, G. C., Hering, B. J.

“…There is a need for simple, quantitative and prospective assays for islet quality assessment that are predictive of islet transplantation outcome. The current…”
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Prolonged Insulin Independence After Islet Allotransplants in Recipients with Type 1 Diabetes by Bellin, M. D., Kandaswamy, R., Parkey, J., Zhang, H.‐J., Liu, B., Ihm, S. H., Ansite, J. D., Witson, J., Bansal‐Pakala, P., Balamurugan, A. N., Papas, K., Sutherland, D. E. R., Moran, A., Hering, B. J.

“…We sought to determine the long‐term outcomes in type 1 diabetic recipients of intraportal alloislet transplants on a modified immunosuppressive protocol. Six…”
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Islet Transplantation in Type 1 Diabetics Using an Immunosuppressive Protocol Based on the Anti‐LFA‐1 Antibody Efalizumab by Posselt, A. M., Bellin, M. D., Tavakol, M., Szot, G. L., Frassetto, L. A., Masharani, U., Kerlan, R. K., Fong, L., Vincenti, F. G., Hering, B. J., Bluestone, J. A., Stock, P. G.

“…The applicability of islet transplantation as treatment for type 1 diabetes is limited by renal and islet toxicities of currently available immunosuppressants…”
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c-Jun N-terminal kinase JNK participates in cytokine- and isolation stress-induced rat pancreatic islet apoptosis by Abdelli, S, Abderrahmani, A, Hering, B. J, Beckmann, J. S, Bonny, C

“…Aims/hypothesis The protocols used for the preparation of human pancreatic islets immediately induce a sustained and massive activation of the c-Jun-N-terminal…”
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Engraftment of Adult Porcine Islet Xenografts in Diabetic Nonhuman Primates Through Targeting of Costimulation Pathways by Cardona, K., Milas, Z., Strobert, E., Cano, J., Jiang, W., Safley, S. A., Gangappa, S., Hering, B. J., Weber, C. J., Pearson, T. C., Larsen, C. P.

“…Recent advances in human allogeneic islet transplantation have established β‐cell replacement therapy as a potentially viable treatment option for individuals…”
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Human Islet Isolation for Autologous Transplantation: Comparison of Yield and Function Using SERVA/Nordmark Versus Roche Enzymes by Anazawa, T., Balamurugan, A. N., Bellin, M., Zhang, H. J., Matsumoto, S., Yonekawa, Y., Tanaka, T., Loganathan, G., Papas, K. K., Beilman, G. J., Hering, B. J., Sutherland, D. E. R.

“…Islet autotransplantation (IAT) is used to preserve as much insulin‐secretory capacity as possible in patients undergoing total pancreatectomy for painful…”
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Antiproinflammatory effects of iodixanol (OptiPrep)-based density gradient purification on human islet preparations by Mita, A, Ricordi, C, Messinger, S, Miki, A, Misawa, R, Barker, S, Molano, R D, Haertter, R, Khan, A, Miyagawa, S, Pileggi, A, Inverardi, L, Alejandro, R, Hering, B J, Ichii, H

“…Islet isolation and purification using a continuous density gradient may reduce the volume of tissue necessary for implantation into patients, therefore…”
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Validation of methodologies for quantifying isolated human islets: an islet cell resources study by Kissler, H.J., Niland, J.C., Olack, B., Ricordi, C., Hering, B.J., Naji, A., Kandeel, F., Oberholzer, J., Fernandez, L., Contreras, J., Stiller, T., Sowinski, J., Kaufman, D.B.

“…Kissler HJ, Niland JC, Olack B, Ricordi C, Hering B J, Naji A, Kandeel F, Oberholzer J, Fernandez L, Contreras J, Stiller T, Sowinski J, Kaufman DB. Validation…”
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Pancreas Oxygenation Is Limited During Preservation With the Two-Layer Method by Papas, K.K., Hering, B.J., Gunther, L., Rappel, M.J., Colton, C.K., Avgoustiniatos, E.S.

“…The two-layer method (TLM) for pancreas preservation reportedly improves islet yield and transplantation outcome relative to previous methods. Increased ATP…”
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Infection by porcine endogenous retrovirus after islet xenotransplantation in SCID mice by Salomon, Daniel R, van der Laan, Luc J.W, Lockey, Christopher, Griffeth, Bradley C, Frasier, Francine S, Wilson, Carolyn A, Onions, David E, Hering, Bernhard J, Long, Zhifeng, Otto, Edward, Torbett, Bruce E

“…Animal donors such as pigs could provide an alternative source of organs for transplantation. However, the promise of xenotransplantation is offset by the…”
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Improved Method of Porcine Pancreas Procurement With Arterial Flush and Ductal Injection Enhances Islet Isolation Outcome by Anazawa, T, Balamurugan, A.N, Papas, K.K, Avgoustiniatos, E.S, Ferrer, J, Matsumoto, S, Sutherland, D.E.R, Hering, B.J

“…Abstract Background Several pancreas procurement procedures have been used for porcine islet isolation; however, their impact on outcomes has not been…”
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Culture of Impure Human Islet Fractions in the Presence of Alpha-1 Antitrypsin Prevents Insulin Cleavage and Improves Islet Recovery by Loganathan, G, Dawra, R.K, Pugazhenthi, S, Wiseman, A.C, Sanders, M.A, Saluja, A.K, Sutherland, D.E.R, Hering, B.J, Balamurugan, A.N

“…Abstract Background Exocrine tissue is commonly cotransplanted with islets in autografting and allotransplantation of impure preparations. Proteases and…”
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High-Density Culture of Human Islets on Top of Silicone Rubber Membranes by Papas, K.K., Avgoustiniatos, E.S., Tempelman, L.A., Weir, G.C., Colton, C.K., Pisania, A., Rappel, M.J., Friberg, A.S., Bauer, A.C., Hering, B.J.

“…Islet culture has emerged as a standard practice prior to clinical transplantation. However, culturing large numbers of islets requires low islet density…”
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Rapid Quantitative Assessment of the Pig Pancreas Biopsy Predicts Islet Yield by Anazawa, T, Balamurugan, A.N, Matsumoto, S, LaFreniere, S.A, O'Brien, T.D, Sutherland, D.E.R, Hering, B.J

“…Abstract Background The cost of islet procurement from donor pigs is increased by the use of organs that produce low yields. We developed an assessment system…”
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Islet Product Characteristics and Factors Related to Successful Human Islet Transplantation From the Collaborative Islet Transplant Registry (CITR) 1999–2010 by Balamurugan, A. N., Naziruddin, B., Lockridge, A., Tiwari, M., Loganathan, G., Takita, M., Matsumoto, S., Papas, K., Trieger, M., Rainis, H., Kin, T., Kay, T. W., Wease, S., Messinger, S., Ricordi, C., Alejandro, R., Markmann, J., Kerr‐Conti, J., Rickels, M. R., Liu, C., Zhang, X., Witkowski, P., Posselt, A., Maffi, P., Secchi, A., Berney, T., O'Connell, P. J., Hering, B. J., Barton, F. B.

“…The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations and transplants. This retrospective report analyzed 1017 islet…”
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The ATP/DNA Ratio Is a Better Indicator of Islet Cell Viability Than the ADP/ATP Ratio by Suszynski, T.M, Wildey, G.M, Falde, E.J, Cline, G.W, Maynard, K. Stewart, Ko, N, Sotiris, J, Naji, A, Hering, B.J, Papas, K.K

“…Abstract Real-time, accurate assessment of islet viability is critical for avoiding transplantation of nontherapeutic preparations. Measurements of the…”
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