Search Results - "Hering, B."

Potent Induction Immunotherapy Promotes Long‐Term Insulin Independence After Islet Transplantation in Type 1 Diabetes by Bellin, M. D., Barton, F. B., Heitman, A., Harmon, J. V., Kandaswamy, R., Balamurugan, A. N., Sutherland, D. E. R., Alejandro, R., Hering, B. J.

“…The seemingly inexorable decline in insulin independence after islet transplant alone (ITA) has raised concern about its clinical utility. We hypothesized that…”
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Advancing islet transplantation: from engraftment to the immune response by Gibly, R. F., Graham, J. G., Luo, X., Lowe, W. L., Hering, B. J., Shea, L. D.

“…The promise and progress of islet transplantation for treating type 1 diabetes has been challenged by obstacles to patient accessibility and long-term graft…”
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Proposed Thresholds for Pancreatic Tissue Volume for Safe Intraportal Islet Autotransplantation After Total Pancreatectomy by Wilhelm, J. J., Bellin, M. D., Dunn, T. B., Balamurugan, A. N., Pruett, T. L., Radosevich, D. M., Chinnakotla, S., Schwarzenberg, S. J., Freeman, M. L., Hering, B. J., Sutherland, D. E. R., Beilman, G. J.

“…The simple question of how much tissue volume (TV) is really safe to infuse in total pancreatectomy–islet autotransplantation (TP–IAT) for chronic pancreatitis…”
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Dimorphic histopathology of long-standing childhood-onset diabetes by Gianani, R, Campbell-Thompson, M, Sarkar, S. A, Wasserfall, C, Pugliese, A, Solis, J. M, Kent, S. C, Hering, B. J, West, E, Steck, A, Bonner-Weir, S, Atkinson, M. A, Coppieters, K, von Herrath, M, Eisenbarth, G. S

“…Aims/hypothesis Childhood diabetes is thought to usually result from autoimmune beta cell destruction (type 1A) with eventual total loss of beta cells…”
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Human Islet Oxygen Consumption Rate and DNA Measurements Predict Diabetes Reversal in Nude Mice by Papas, K. K., Colton, C. K., Nelson, R. A., Rozak, P. R., Avgoustiniatos, E. S., Scott, W. E., Wildey, G. M., Pisania, A., Weir, G. C., Hering, B. J.

“…There is a need for simple, quantitative and prospective assays for islet quality assessment that are predictive of islet transplantation outcome. The current…”
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Islet Product Characteristics and Factors Related to Successful Human Islet Transplantation From the Collaborative Islet Transplant Registry (CITR) 1999–2010 by Balamurugan, A. N., Naziruddin, B., Lockridge, A., Tiwari, M., Loganathan, G., Takita, M., Matsumoto, S., Papas, K., Trieger, M., Rainis, H., Kin, T., Kay, T. W., Wease, S., Messinger, S., Ricordi, C., Alejandro, R., Markmann, J., Kerr‐Conti, J., Rickels, M. R., Liu, C., Zhang, X., Witkowski, P., Posselt, A., Maffi, P., Secchi, A., Berney, T., O'Connell, P. J., Hering, B. J., Barton, F. B.

“…The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations and transplants. This retrospective report analyzed 1017 islet…”
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Prolonged Insulin Independence After Islet Allotransplants in Recipients with Type 1 Diabetes by Bellin, M. D., Kandaswamy, R., Parkey, J., Zhang, H.‐J., Liu, B., Ihm, S. H., Ansite, J. D., Witson, J., Bansal‐Pakala, P., Balamurugan, A. N., Papas, K., Sutherland, D. E. R., Moran, A., Hering, B. J.

“…We sought to determine the long‐term outcomes in type 1 diabetic recipients of intraportal alloislet transplants on a modified immunosuppressive protocol. Six…”
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Islet Transplantation in Type 1 Diabetics Using an Immunosuppressive Protocol Based on the Anti‐LFA‐1 Antibody Efalizumab by Posselt, A. M., Bellin, M. D., Tavakol, M., Szot, G. L., Frassetto, L. A., Masharani, U., Kerlan, R. K., Fong, L., Vincenti, F. G., Hering, B. J., Bluestone, J. A., Stock, P. G.

“…The applicability of islet transplantation as treatment for type 1 diabetes is limited by renal and islet toxicities of currently available immunosuppressants…”
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Unmethylated Insulin DNA Is Elevated After Total Pancreatectomy With Islet Autotransplantation: Assessment of a Novel Beta Cell Marker by Bellin, M. D., Clark, P., Usmani‐Brown, S., Dunn, T. B., Beilman, G. J., Chinnakotla, S., Pruett, T. L., Ptacek, P., Hering, B. J., Wang, Z., Gilmore, T., Wilhelm, J. J., Hodges, J. S., Moran, A., Herold, K. C.

“…Beta cell death may occur both after islet isolation and during infusion back into recipients undergoing total pancreatectomy with islet autotransplantation…”
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Association between primary graft function and 5-year outcomes of islet allogeneic transplantation in type 1 diabetes: a retrospective, multicentre, observational cohort study in 1210 patients from the Collaborative Islet Transplant Registry by Chetboun, Mikaël, Drumez, Elodie, Ballou, Cassandra, Maanaoui, Mehdi, Payne, Elizabeth, Barton, Franca, Kerr-Conte, Julie, Vantyghem, Marie-Christine, Piemonti, Lorenzo, Rickels, Michael R, Labreuche, Julien, Pattou, François, Alejandro, R, Aull, M, Bellin, M, Berney, T, Borja-Cacho, D, Brayman, K, Cagliero, E, Caiazzo, R, Cattral, M, Coates, T, Danielson, K, Defrance, F, De Koning, E, Desai, C, Desai, N, Gaber, A O, Gmyr, V, Gores, P, Goss, J A, Gottllieb, P, Greenbaum, C, Hardy, M, Harlan, D, Hering, B, Kandeel, F, Kaufman, D, Kay, T, Keymeulen, B, Khan, K, Kudva, Y, Larsen, C, Le Mapihan, K, Levy, G, Levy, M, Loudovaris, T, Lundgren, T, Maffi, P, Markmann, J, Marks, W H, Naji, A, O'Connell, P, Oberholzer, J, Odorico, J, Onaca, N, Pattou, F, Piemonti, L, Pipeleers, D, Posselt, A, Rajab, A, Raverdy, V, Rickels, M R, Ricordi, C, Rossini, A A, Saudek, F, Schrope, B, Secchi, A, Senior, P, Shapiro, A M J, Shaw, J, Stock, P, Thomas, D, Thompson, M J, Vantyghem, M C, Vargas, L, Wang, H, Wiseman, A, Witkowski, P, Yoon, K

“…Allogeneic islet transplantation is a validated therapy in type 1 diabetes; however, there is decline of transplanted islet graft function over time and the…”
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Defective Glucagon Secretion During Hypoglycemia After Intrahepatic But Not Nonhepatic Islet Autotransplantation by Bellin, M. D., Parazzoli, S., Oseid, E., Bogachus, L. D., Schuetz, C., Patti, M. E., Dunn, T., Pruett, T., Balamurugan, A. N., Hering, B., Beilman, G., Sutherland, D. E. R., Robertson, R. P.

“…Defective glucagon secretion during hypoglycemia after islet transplantation has been reported in animals and humans with type 1 diabetes. To ascertain whether…”
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The prognostic significance of glutamic acid decarboxylase antibodies in patients with chronic pancreatitis undergoing total pancreatectomy with islet autotransplantation by Kizilgul, M., Wilhelm, J.J., Dunn, T.B., Beilman, G.J., Pruett, T.L., Chinnakotla, S., Amin, K., Hering, B.J., Bellin, M.D.

“…Islet autotransplantation (IAT) is considered a ‘non-immune’ model of islet transplant, with no risk for autoimmune-mediated beta cell loss, but we have…”
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Engraftment of Adult Porcine Islet Xenografts in Diabetic Nonhuman Primates Through Targeting of Costimulation Pathways by Cardona, K., Milas, Z., Strobert, E., Cano, J., Jiang, W., Safley, S. A., Gangappa, S., Hering, B. J., Weber, C. J., Pearson, T. C., Larsen, C. P.

“…Recent advances in human allogeneic islet transplantation have established β‐cell replacement therapy as a potentially viable treatment option for individuals…”
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c-Jun N-terminal kinase JNK participates in cytokine- and isolation stress-induced rat pancreatic islet apoptosis by Abdelli, S, Abderrahmani, A, Hering, B. J, Beckmann, J. S, Bonny, C

“…Aims/hypothesis The protocols used for the preparation of human pancreatic islets immediately induce a sustained and massive activation of the c-Jun-N-terminal…”
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Sitagliptin Treatment After Total Pancreatectomy With Islet Autotransplantation: A Randomized, Placebo‐Controlled Study by Bellin, M. D., Beilman, G. J., Dunn, T. B., Pruett, T. L., Sutherland, D. E. R., Chinnakotla, S., Hodges, J. S., Lane, A., Ptacek, P., Berry, K. L., Hering, B. J., Moran, A.

“…Insulin independence after total pancreatectomy and islet autotransplant (TPIAT) for chronic pancreatitis is limited by a high rate of postprocedure beta cell…”
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Human Islet Isolation for Autologous Transplantation: Comparison of Yield and Function Using SERVA/Nordmark Versus Roche Enzymes by Anazawa, T., Balamurugan, A. N., Bellin, M., Zhang, H. J., Matsumoto, S., Yonekawa, Y., Tanaka, T., Loganathan, G., Papas, K. K., Beilman, G. J., Hering, B. J., Sutherland, D. E. R.

“…Islet autotransplantation (IAT) is used to preserve as much insulin‐secretory capacity as possible in patients undergoing total pancreatectomy for painful…”
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Metabolic Assessment Prior to Total Pancreatectomy and Islet Autotransplant: Utility, Limitations and Potential by Lundberg, R., Beilman, G. J., Dunn, T. B., Pruett, T. L., Chinnakotla, S. C., Radosevich, D. M., Robertson, R. P., Ptacek, P., Balamurugan, A. N., Wilhelm, J. J., Hering, B. J., Sutherland, D. E. R., Moran, A., Bellin, M. D.

“…Islet autotransplant (IAT) may ameliorate postsurgical diabetes following total pancreatectomy (TP), but outcomes are dependent upon islet mass, which is…”
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Infection by porcine endogenous retrovirus after islet xenotransplantation in SCID mice by Salomon, Daniel R, van der Laan, Luc J.W, Lockey, Christopher, Griffeth, Bradley C, Frasier, Francine S, Wilson, Carolyn A, Onions, David E, Hering, Bernhard J, Long, Zhifeng, Otto, Edward, Torbett, Bruce E

“…Animal donors such as pigs could provide an alternative source of organs for transplantation. However, the promise of xenotransplantation is offset by the…”
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Comprehensive health assessment and five-yr follow-up of allogeneic islet transplant recipients by Radosevich, D. M., Jevne, R., Bellin, M., Kandaswamy, R., Sutherland, D. E. R., Hering, B. J.

“…In patients with type 1 diabetes mellitus (T1DM) complicated by severe hypoglycemic episodes, fear of hypoglycemia can significantly impact daily life. We…”
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Validation of methodologies for quantifying isolated human islets: an islet cell resources study by Kissler, H.J., Niland, J.C., Olack, B., Ricordi, C., Hering, B.J., Naji, A., Kandeel, F., Oberholzer, J., Fernandez, L., Contreras, J., Stiller, T., Sowinski, J., Kaufman, D.B.

“…Kissler HJ, Niland JC, Olack B, Ricordi C, Hering B J, Naji A, Kandeel F, Oberholzer J, Fernandez L, Contreras J, Stiller T, Sowinski J, Kaufman DB. Validation…”
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