Obesity and Inflammation: Epidemiology, Risk Factors, and Markers of Inflammation

Obesity and Inflammation: Epidemiology, Risk Factors, and Markers of Inflammation

Obesity is a public health problem that has reached epidemic proportions with an increasing worldwide prevalence. The global emergence of obesity increases the risk of developing chronic metabolic disorders. Thus, it is an economic issue that increased the costs of the comorbidities associated. More...

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Bibliographic Details
Published in:International Journal of Endocrinology Vol. 2013; no. 2013; pp. 355 - 365-140
Main Authors: Heriberto Rodriguez-Hernindez, Luis E. Simental-Mendia, Gabriela Rodriguez-Ramirez, Miguel A. Reyes-Romero
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Limiteds 01-01-2013
Hindawi Puplishing Corporation
Hindawi Publishing Corporation
John Wiley & Sons, Inc
Hindawi Limited
Subjects:
Adipocytes
Apoptosis
Arthritis
Body mass index
Cancer
Cardiovascular disease
Chronic diseases
Cytokines
Development and progression
Diabetes
Diet
Endocrinology
Epidemiology
Gene expression
Health aspects
Homeostasis
Hyperglycemia
Hypertension
Immune system
Inflammation
Insulin resistance
Kinases
Liver diseases
Metabolism
Mortality
Obesity
Proteins
Review
Risk factors
Weight control
Canada
United States > US
Mexico
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Summary:Obesity is a public health problem that has reached epidemic proportions with an increasing worldwide prevalence. The global emergence of obesity increases the risk of developing chronic metabolic disorders. Thus, it is an economic issue that increased the costs of the comorbidities associated. Moreover, in recent years, it has been demonstrated that obesity is associated with chronic systemic inflammation, this status is conditioned by the innate immune system activation in adipose tissue that promotes an increase in the production and release of pro-inflammatory cytokines that contribute to the triggering of the systemic acute-phase response which is characterized by elevation of acute-phase protein levels. On this regard, low-grade chronic inflammation is a characteristic of various chronic diseases such as metabolic syndrome, cardiovascular disease, diabetes, hypertension, non-alcoholic fatty liver disease, and some cancers, among others, which are also characterized by obesity condition. Thus, a growing body of evidence supports the important role that is played by the inflammatory response in obesity condition and the pathogenesis of chronic diseases related.
Bibliography:ObjectType-Article-1
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Academic Editor: Abdelfattah El Ouaamari
ISSN:1687-8337
1687-8345
DOI:10.1155/2013/678159