Search Results - "Hergenroeder, Georgene W."

Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities by Davis, Karen D., Aghaeepour, Nima, Ahn, Andrew H., Angst, Martin S., Borsook, David, Brenton, Ashley, Burczynski, Michael E., Crean, Christopher, Edwards, Robert, Gaudilliere, Brice, Hergenroeder, Georgene W., Iadarola, Michael J., Iyengar, Smriti, Jiang, Yunyun, Kong, Jiang-Ti, Mackey, Sean, Saab, Carl Y., Sang, Christine N., Scholz, Joachim, Segerdahl, Marta, Tracey, Irene, Veasley, Christin, Wang, Jing, Wager, Tor D., Wasan, Ajay D., Pelleymounter, Mary Ann

“…Pain medication plays an important role in the treatment of acute and chronic pain conditions, but some drugs, opioids in particular, have been overprescribed…”
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Biomarkers for the diagnosis and prognosis of mild traumatic brain injury/concussion by Jeter, Cameron B, Hergenroeder, Georgene W, Hylin, Michael J, Redell, John B, Moore, Anthony N, Dash, Pramod K

“…Mild traumatic brain injury (mTBI) results from a transfer of mechanical energy into the brain from traumatic events such as rapid acceleration/deceleration, a…”
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Inflammation in delayed ischemia and functional outcomes after subarachnoid hemorrhage by Ahn, Sung-Ho, Savarraj, Jude P J, Parsha, Kaushik, Hergenroeder, Georgene W, Chang, Tiffany R, Kim, Dong H, Kitagawa, Ryan S, Blackburn, Spiros L, Choi, H Alex

“…Inflammatory mechanism has been implicated in delayed cerebral ischemia (DCI) and poor functional outcomes after subarachnoid hemorrhage (SAH). Identification…”
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Traumatic Brain Injury Alters Methionine Metabolism: Implications for Pathophysiology by Dash, Pramod K, Hergenroeder, Georgene W, Jeter, Cameron B, Choi, H Alex, Kobori, Nobuhide, Moore, Anthony N

“…Methionine is an essential proteinogenic amino acid that is obtained from the diet. In addition to its requirement for protein biosynthesis, methionine is…”
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Human neural progenitors derived from integration-free iPSCs for SCI therapy by Liu, Ying, Zheng, Yiyan, Li, Shenglan, Xue, Haipeng, Schmitt, Karl, Hergenroeder, Georgene W., Wu, Jiaqian, Zhang, Yuanyuan, Kim, Dong H., Cao, Qilin

“…As a potentially unlimited autologous cell source, patient induced pluripotent stem cells (iPSCs) provide great capability for tissue regeneration,…”
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Serum IL-6: a candidate biomarker for intracranial pressure elevation following isolated traumatic brain injury by Hergenroeder, Georgene W, Moore, Anthony N, McCoy, Jr, J Philip, Samsel, Leigh, Ward, 3rd, Norman H, Clifton, Guy L, Dash, Pramod K

“…Increased intracranial pressure (ICP) is a serious, life-threatening, secondary event following traumatic brain injury (TBI). In many cases, ICP rises in a…”
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Machine Learning to Predict Delayed Cerebral Ischemia and Outcomes in Subarachnoid Hemorrhage by Savarraj, Jude P.J., Hergenroeder, Georgene W., Zhu, Liang, Chang, Tiffany, Park, Soojin, Megjhani, Murad, Vahidy, Farhaan S., Zhao, Zhongming, Kitagawa, Ryan S., Choi, H. Alex

“…OBJECTIVE:To determine whether machine learning (ML) algorithms can improve the prediction of delayed cerebral ischemia (DCI) and functional-outcomes after…”
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Human traumatic brain injury alters plasma microRNA levels by Redell, John B, Moore, Anthony N, Ward, 3rd, Norman H, Hergenroeder, Georgene W, Dash, Pramod K

“…Circulating microRNAs (miRNAs) present in the serum/plasma are characteristically altered in many pathological conditions, and have been employed as diagnostic…”
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Lysophospholipids Are Associated With Outcomes in Hospitalized Patients With Mild Traumatic Brain Injury by Gusdon, Aaron M, Savarraj, Jude Pj, Redell, John B, Paz, Atzhiry, Hinds, Sarah, Burkett, Angela, Torres, Glenda, Ren, Xuefang, Badjatia, Neeraj, Hergenroeder, Georgene W, Moore, Anthony N, Choi, H Alex, Dash, Pramod K

“…Mild traumatic brain injury (mTBI) accounts for 70-90% of all TBI cases. Lipid metabolites have important roles in plasma membrane biogenesis, function, and…”
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Systematic model of peripheral inflammation after subarachnoid hemorrhage by Savarraj, Jude P.J, Parsha, Kaushik, Hergenroeder, Georgene W, Zhu, Liang, Bajgur, Suhas S, Ahn, Sungho, Lee, Kiwon, Chang, Tiffany, Kim, Dong H, Liu, Yin, Choi, H Alex

“…OBJECTIVE:To investigate inflammatory processes after aneurysmal subarachnoid hemorrhage (aSAH) with network models. METHODS:This is a retrospective…”
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Postmortem study of organ-specific toxicity in glioblastoma patients treated with a combination of temozolomide, irinotecan and bevacizumab by Lu, Guangrong, Zhu, Ping, Rao, Mayank, Linendoll, Nadine, Buja, L. Maximilian, Bhattacharjee, Meenakshi B., Brown, Robert E., Ballester, Leomar Y., Tian, Xuejun, Pilichowska, Monika, Wu, Julian K., Hergenroeder, Georgene W., Glass, Williams F., Chen, Lei, Zhang, Rongzhen, Pillai, Anil K., Hunter, Robert L., Zhu, Jay-Jiguang

“…Purpose Systemic chemotherapy including monotherapy with temozolomide (TMZ) or bevacizumab (BEV); two-drug combinations, such as irinotecan (IRI) and BEV, TMZ…”
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Human mild traumatic brain injury decreases circulating branched-chain amino acids and their metabolite levels by Jeter, Cameron B, Hergenroeder, Georgene W, Ward, 3rd, Norman H, Moore, Anthony N, Dash, Pramod K

“…The pathophysiology of traumatic brain injury (TBI) is complex and not well understood. Because pathophysiology has ramifications for injury progression and…”
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THSD1 (Thrombospondin Type 1 Domain Containing Protein 1) Mutation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage by Santiago-Sim, Teresa, Fang, Xiaoqian, Hennessy, Morgan L, Nalbach, Stephen V, DePalma, Steven R, Lee, Ming Sum, Greenway, Steven C, McDonough, Barbara, Hergenroeder, Georgene W, Patek, Kyla J, Colosimo, Sarah M, Qualmann, Krista J, Hagan, John P, Milewicz, Dianna M, MacRae, Calum A, Dymecki, Susan M, Seidman, Christine E, Seidman, J.G, Kim, Dong H

“…BACKGROUND AND PURPOSE—A ruptured intracranial aneurysm (IA) is the leading cause of a subarachnoid hemorrhage. This study seeks to define a specific gene…”
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Increased Levels of Circulating Glial Fibrillary Acidic Protein and Collapsin Response Mediator Protein-2 Autoantibodies in the Acute Stage of Spinal Cord Injury Predict the Subsequent Development of Neuropathic Pain by Hergenroeder, Georgene W, Redell, John B, Choi, H Alex, Schmitt, Lisa, Donovan, William, Francisco, Gerard E, Schmitt, Karl, Moore, Anthony N, Dash, Pramod K

“…Neuropathic pain develops in 40-70% of spinal cord injury (SCI) patients and markedly compromises quality of life. We examined plasma from SCI patients for…”
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Hypothermia for Patients Requiring Evacuation of Subdural Hematoma: A Multicenter Randomized Clinical Trial by Hergenroeder, Georgene W., Yokobori, Shoji, Choi, Huimahn Alex, Schmitt, Karl, Detry, Michelle A., Schmitt, Lisa H., McGlothlin, Anna, Puccio, Ava M., Jagid, Jonathan, Kuroda, Yasuhiro, Nakamura, Yukihiko, Suehiro, Eiichi, Ahmad, Faiz, Viele, Kert, Wilde, Elisabeth A., McCauley, Stephen R., Kitagawa, Ryan S., Temkin, Nancy R., Timmons, Shelly D., Diringer, Michael N., Dash, Pramod K., Bullock, Ross, Okonkwo, David O., Berry, Donald A., Kim, Dong H.

“…Background Hypothermia is neuroprotective in some ischemia–reperfusion injuries. Ischemia–reperfusion injury may occur with traumatic subdural hematoma (SDH)…”
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Identification of autoantibodies to glial fibrillary acidic protein in spinal cord injury patients by Hergenroeder, Georgene W, Moore, Anthony N, Schmitt, Karl M, Redell, John B, Dash, Pramod K

“…Traumatic spinal cord injury (SCI) is a devastating injury causing significant morbidity and mortality. Experimental studies have demonstrated that SCI induced…”
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ZIP4 is a novel molecular marker for glioma by Lin, Yi, Chen, Yong, Wang, Yongzhi, Yang, Jingxuan, Zhu, Vivian F, Liu, Yulun, Cui, Xiaobo, Chen, Leon, Yan, Wei, Jiang, Tao, Hergenroeder, Georgene W, Fletcher, Stephen A, Levine, Jonathan M, Kim, Dong H, Tandon, Nitin, Zhu, Jay-Jiguang, Li, Min

“…Dysregulated zinc transport has been observed in many cancers. However, the status of zinc homeostasis and the expression profile of zinc transporters in brain…”
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Elevated inflammation and decreased platelet activity is associated with poor outcomes after traumatic brain injury by Lewis, Cole T., Savarraj, Jude P.J., McGuire, Mary F., Hergenroeder, Georgene W., Alex Choi, H., Kitagawa, Ryan S.

“…•Investigation of systemic inflammatory response after Traumatic Brain Injury (TBI).•Poor outcomes associated with elevated levels of IL6 and IL10.•Poor…”
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Human traumatic brain injury alters circulating L-arginine and its metabolite levels: possible link to cerebral blood flow, extracellular matrix remodeling, and energy status by Jeter, Cameron B, Hergenroeder, Georgene W, Ward, 3rd, Norman H, Moore, Anthony N, Dash, Pramod K

“…Altered cerebral blood flow, cell-matrix interactions, and energy metabolism are secondary pathologies contributing to outcome after traumatic brain injury…”
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Quantification of Cerebral Edema After Subarachnoid Hemorrhage by Choi, H. Alex, Bajgur, Suhas S., Jones, Wesley H., Savarraj, Jude P. J., Ko, Sang-Bae, Edwards, Nancy J., Chang, Tiffany R., Hergenroeder, Georgene W., Dannenbaum, Mark J., Chen, P. Roc, Day, Arthur L., Kim, Dong H., Lee, Kiwon, Grotta, James C.

“…Background Global cerebral edema (GCE) is a manifestation of early brain injury (EBI) after subarachnoid hemorrhage (SAH) and is an independent risk factor for…”
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