Search Results - "Hereñú, Claudia B."

Early IGF-1 Gene Therapy Prevented Oxidative Stress and Cognitive Deficits Induced by Traumatic Brain Injury by Montivero, Agustín. J., Ghersi, Marisa. S., Silvero C, M. Jazmín, Artur de la Villarmois, Emilce, Catalan-Figueroa, Johanna, Herrera, Macarena, Becerra, María Cecilia, Hereñú, Claudia. B., Pérez, Mariela. F.

“…Traumatic Brain Injury (TBI) remains a leading cause of morbidity and mortality in adults under 40 years old. Once primary injury occurs after TBI,…”
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Intracisternal IGF‐1 gene therapy abrogates kainic acid‐induced excitotoxic damage of the rat spinal cord by Nishida, Fabián, Zanuzzi, Carolina N., Sisti, María S., Falomir Lockhart, Eugenia, Camiña, Agustina E., Hereñú, Claudia B., Bellini, María J., Portiansky, Enrique L.

“…Development of alternative therapies for treating functional deficits after different neurological damages is a challenge in neuroscience. Insulin‐like growth…”
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Magnetic field-assisted gene delivery: achievements and therapeutic potential by Schwerdt, Jose I, Goya, Gerardo F, Calatayud, M Pilar, Hereñú, Claudia B, Reggiani, Paula C, Goya, Rodolfo G

“…The discovery in the early 2000's that magnetic nanoparticles (MNPs) complexed to nonviral or viral vectors can, in the presence of an external magnetic field,…”
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Rejuvenation by cell reprogramming: a new horizon in gerontology by Goya, Rodolfo G, Lehmann, Marianne, Chiavellini, Priscila, Canatelli-Mallat, Martina, Hereñú, Claudia B, Brown, Oscar A

“…The discovery of animal cloning and subsequent development of cell reprogramming technology were quantum leaps as they led to the achievement of rejuvenation…”
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Regulatable adenovector harboring the GFP and Yamanaka genes for implementing regenerative medicine in the brain by Lehmann, Marianne, Canatelli-Mallat, Martina, Chiavellini, Priscila, Morel, Gustavo R., Reggiani, Paula C., Hereñú, Claudia B., Goya, Rodolfo G.

“…Biological rejuvenation by partial cell reprogramming is an emerging avenue of research. In this context, regulatable pluripotency gene expression systems are…”
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Insulin-like growth factor-I gene delivery to astrocytes reduces their inflammatory response to lipopolysaccharide by Bellini, Maria J, Hereñú, Claudia B, Goya, Rodolfo G, Garcia-Segura, Luis M

“…Insulin-like growth factor-I (IGF-I) exerts neuroprotective actions in the central nervous system that are mediated at least in part by control of activation…”
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Early Cognitive Impairment Behind Nigrostriatal Circuit Neurotoxicity: Are Astrocytes Involved? by Herrera, Macarena L., Deza-Ponzio, Romina, Ghersi, Marisa S., de la Villarmois, Emilce A., Virgolini, Miriam B., Pérez, Mariela F., Molina, Victor A., Bellini, María J., Hereñú, Claudia B.

“…Cognitive dysfunction is one of the most severe nonmotor symptoms of nigrostriatal impairment. This occurs as a result of profound functional and morphological…”
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The neuroendocrine system as a model to evaluate experimental gene therapy by Hereñú, Claudia B, Brown, Oscar A, Sosa, Yolanda E, Morel, Gustavo R, Reggiani, Paula C, Bellini, Maria J, Goya, Rodolfo G

“…The implementation of experimental gene therapy in animal models of neurological diseases is an area of growing interest. Although the neuroendocrine system…”
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Gene therapy and cell reprogramming for the aging brain: achievements and promise by Pardo, Joaquín, Morel, Gustavo R, Astiz, Mariana, Schwerdt, José I, León, Micaela L, Rodríguez, Silvia S, Hereñú, Claudia B, Goya, Rodolfo G

“…In the central nervous system, cholinergic and dopaminergic (DA) neurons are among the cells most susceptible to the deleterious effects of age. Thus, the…”
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Thymus and aging: potential of gene therapy for restoration of endocrine thymic function in thymus-deficient animal models by Goya, Rodolfo G, Cónsole, Gloria M, Hereñú, Claudia B, Brown, Oscar A, Rimoldi, Omar J

“…The aim of the present article is to discuss the potential of gene therapy for thymic hormones as a novel therapeutic strategy to treat dyshomeostatic states…”
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Hippocampal DNA Methylation, Epigenetic Age, and Spatial Memory Performance in Young and Old Rats by Chiavellini, Priscila, Lehmann, Marianne, Canatelli Mallat, Martina, Zoller, Joseph A, Herenu, Claudia B, Morel, Gustavo R, Horvath, Steve, Goya, Rodolfo G

“…In humans and rats, aging is associated with a progressive deterioration of spatial learning and memory. These functional alterations are correlated with…”
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Young Plasma Rejuvenates Blood DNA Methylation Profile, Extends Mean Lifespan, and Improves Physical Appearance in Old Rats by Chiavellini, Priscila, Lehmann, Marianne, Gallardo, Maria D, Mallat, Martina Canatelli, Pasquini, Diana C, Zoller, Joseph A, Gordevicius, Juozas, Girard, Mauricio, Lacunza, Ezequiel, Herenu, Claudia B, Horvath, Steve, Goya, Rodolfo G

“…Abstract There is converging evidence that young blood conveys cells, vesicles, and molecules able to revitalize function and restore organ integrity in old…”
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Effect of insulin-like growth factor-I gene therapy on the somatotropic axis in experimental prolactinomas by Cónsole, Gloria M, Hereñú, Claudia B, Camihort, Gisela A, Luna, Georgina C, Ferese, Celia, Goya, Rodolfo G

“…Insulin-like growth factor-I (IGF-I) provides a physiologic feedback effect within the somatotropic axis. Gene therapy was implemented in young female…”
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Aging and rejuvenation - a modular epigenome model by Chiavellini, Priscila, Canatelli-Mallat, Martina, Lehmann, Marianne, Gallardo, Maria D, Herenu, Claudia B, Cordeiro, Jose L, Clement, James, Goya, Rodolfo G

“…The view of aging has evolved in parallel with the advances in biomedical sciences. Long considered as an irreversible process where interventions were only…”
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Morphological changes induced by insulin-like growth factor-I gene therapy in pituitary cell populations in experimental prolactinomas by Camihort, Gisela A, Hereñú, Claudia B, Luna, Georgina C, Rodríguez, Silvia S, Bracamonte, María I, Goya, Rodolfo G, Cónsole, Gloria M

“…In previous studies, we assessed the effects of intrapituitary injection of a recombinant adenoviral vector (RAd) harboring the cDNA for rat insulin-like…”
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Insulin-like growth factor-I gene therapy reverses morphologic changes and reduces hyperprolactinemia in experimental rat prolactinomas by Console, Gloria M, Herenu, Claudia B, Camihort, Gisela A, Luna, Georgina C, Bracamonte, Maria I, Morel, Gustavo R, Goya, Rodolfo G

“…The implementation of gene therapy for the treatment of pituitary tumors emerges as a promising complement to surgery and may have distinct advantages over…”
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Peripheral and mesencephalic transfer of a synthetic gene for the thymic peptide thymulin by Morel, Gustavo R., Brown, Oscar A., Reggiani, Paula C., Hereñú, Claudia B., Portiansky, Enrique L., Zuccolilli, Gustavo O., Pléau, Jean M., Dardenne, Mireille, Goya, Rodolfo G.

“…Thymulin is a thymic peptide with antiinflammatory activity in the brain. We constructed a recombinant adenoviral vector, RAd-FTS, expressing a synthetic DNA…”
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Reversal of biological age in multiple rat organs by young porcine plasma fraction by Horvath, Steve, Singh, Kavita, Raj, Ken, Khairnar, Shraddha I., Sanghavi, Akshay, Shrivastava, Agnivesh, Zoller, Joseph A., Li, Caesar Z., Herenu, Claudia B., Canatelli-Mallat, Martina, Lehmann, Marianne, Habazin, Siniša, Novokmet, Mislav, Vučković, Frano, Solberg Woods, Leah C., Martinez, Angel Garcia, Wang, Tengfei, Chiavellini, Priscila, Levine, Andrew J., Chen, Hao, Brooke, Robert T., Gordevicius, Juozas, Lauc, Gordan, Goya, Rodolfo G., Katcher, Harold L.

“…Young blood plasma is known to confer beneficial effects on various organs in mice and rats. However, it was not known whether plasma from young adult pigs…”
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Hypophysotropic activity of histone H3 in vitro by Brown, Oscar A., Sosa, Yolanda E., Naumovich, Diana, Hereñú, Claudia B., Goya, Rodolfo G.

“…To assess the effect of histone H3 on pituitary hormone secretion, rat anterior pituitary (AP) cells were used and growth hormone, prolactin, thyrotropin,…”
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Cognitive impairment and morphological changes in the dorsal hippocampus of very old female rats by Morel, G.R, Andersen, T, Pardo, J, Zuccolilli, G.O, Cambiaggi, V.L, Hereñú, C.B, Goya, R.G

“…Highlights • Spatial memory and hippocampal histopathology were assessed in aged female rats. • There is an age-dependent decline in learning in female rats…”
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