Search Results - "Herdewijn, P"

Redesigning the leaving group in nucleic acid polymerization by Herdewijn, P., Marlière, P.

“…Artificial nucleic acids have the potential to propagate genetic information in vivo purposefully insulated from the canonical replication and transcription…”
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Contribution of dihydrouridine in folding of the D-arm in tRNA by Dyubankova, N, Sochacka, E, Kraszewska, K, Nawrot, B, Herdewijn, P, Lescrinier, E

“…Posttranscriptional modifications of transfer RNAs (tRNAs) are proven to be critical for all core aspects of tRNA function. While the majority of tRNA…”
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Achiral, acyclic nucleic acids: synthesis and biophysical studies of a possible prebiotic polymer by Srivastava, P, Abou El Asrar, R, Knies, C, Abramov, M, Froeyen, M, Rozenski, J, Rosemeyer, H, Herdewijn, P

“…The search for prebiotic, nucleic acid precursors is, at its best, a speculative undertaking. Given the complex structure of RNA, it is not very likely that…”
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Molecular Dipstick Test for Diagnosis of Sleeping Sickness by Deborggraeve, S, Claes, F, Laurent, T, Mertens, P, Leclipteux, T, Dujardin, J.C, Herdewijn, P, Büscher, P

“…Human African trypanosomiasis (HAT) or sleeping sickness is a neglected disease that affects poor rural populations across sub-Saharan Africa. Confirmation of…”
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NMR study on the interaction of the conserved CREX 'stem-loop' in the Hepatitis E virus genome with a naphthyridine-based ligand by Dyubankova, N, Froeyen, M, Abramov, M, Mattelaer, H P, Herdewijn, P, Lescrinier, E

“…A 2-amino-1,8-naphthyridine derivative that is described to bind single guanine bulges in RNA-DNA and RNA-RNA duplexes was synthesized and its interaction with…”
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Ajuga remota Benth.: From ethnopharmacology to phytomedical perspective in the treatment of malaria by Cocquyt, K., Cos, P., Herdewijn, P., Maes, L., Van den Steen, P.E., Laekeman, G.

“…Treatment and control of malaria have become more difficult with the spread of drug-resistant parasites and insecticide-resistant mosquito vectors. In the…”
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Conformationally restricted carbohydrate-modified nucleic acids and antisense technology by Herdewijn, P.

“…The study of conformationally restricted carbohydrate modified nucleic acids has given new insights into the concept of the antisense technology. We learned to…”
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Sulfonate derived phosphoramidates as active intermediates in the enzymatic primer-extension of DNA by De, S, Groaz, E, Margamuljana, L, Abramov, M, Marlière, P, Herdewijn, P

“…Novel unnatural 5'-phosphoramidate nucleosides, capable of being processed as substrates by DNA polymerases for multiple nucleotide incorporations, have been…”
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Polymerase-catalyzed synthesis of DNA from phosphoramidate conjugates of deoxynucleotides and amino acids by Adelfinskaya, O., Terrazas, M., Froeyen, M., Marlière, P., Nauwelaerts, K., Herdewijn, P.

“…Some selected amino acids, in particular l-aspartic acid (l-Asp) and l-histidine (l-His), can function as leaving group during polymerase-catalyzed…”
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Post-transcriptional modification mapping in the Clostridium acetobutylicum 16S rRNA by mass spectrometry and reverse transcriptase assays by Emmerechts, Gert, Barbé, Sofie, Herdewijn, Piet, Anné, Jozef, Rozenski, Jef

“…Post-transcriptional modifications in ribosomal RNA are believed to fine-tune the RNA functions. The present study describes the characterization of the…”
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RNA as a target for drug design, the example of Tat-TAR interaction by Froeyen, M, Herdewijn, P

“…One of the new targets in the battle against HIV-1 infection is the interaction between the viral transactivator and the transactivation response (TAR)…”
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Influence of the incorporation of a cyclohexenyl nucleic acid (CeNA) residue onto the sequence d(CGCGAATTCGCG) by Robeyns, Koen, Herdewijn, Piet, Van Meervelt, Luc

“…Cyclohexene nucleic acids (CeNA), which are characterized by the presence of a cyclohexene moiety instead of a natural (deoxy)ribose sugar, are known to…”
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Imidazo[4,5-c]pyridines inhibit the in vitro replication of the classical swine fever virus and target the viral polymerase by Vrancken, R., Paeshuyse, J., Haegeman, A., Puerstinger, G., Froeyen, M., Herdewijn, P., Kerkhofs, P., Neyts, J., Koenen, F.

“…Selective inhibitors of the replication of the classical swine fever virus (CSFV) may have the potential to control the spread of the infection in an epidemic…”
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Antibacterial 5′- O-( N-dipeptidyl)-sulfamoyladenosines by Van de Vijver, P., Vondenhoff, G.H.M., Denivelle, S., Rozenski, J., Verhaegen, J., Van Aerschot, A., Herdewijn, P.

“…Dipeptidyl derivatives of 5′- O-( N- L-aminoacyl)-sulfamoyladenosines, which are inhibitors of aminoacyl-tRNA synthetase enzymes, show altered antibacterial…”
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Differential Patterns of Intracellular Metabolism of 2′,3′-Didehydro-2′,3′-dideoxythymidine and 3′-Azido-2′,3′-dideoxythymidine, Two Potent Anti-human Immunodeficiency Virus Compounds by Balzarini, J, Herdewijn, P, De Clercq, E

“…3′-Azido-2′,3′-dideoxythymidine (AZT) and 2′,3′-didehydro-2′,3′-dideoxythymidine (D4T) are potent and selective inhibitors of human immunodeficiency virus…”
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D-Altritol Nucleic Acids (ANA): Hybridisation Properties, Stability, and Initial Structural Analysis by Allart, Brigitte, Khan, Kamran, Rosemeyer, Helmut, Schepers, Guy, Hendrix, Chris, Rothenbacher, Klaus, Seela, Frank, Van Aerschot, Arthur, Herdewijn, P.

“…Oligonucleotides composed of a phosphorylated D‐altritol backbone (see diagram) with nucleobases in the 2′‐position, hybridise strongly and sequence…”
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A Straightforward Stereoselective Synthesis of d- and l-5-Hydroxy-4-hydroxymethyl-2-cyclohexenylguanine by Wang, Jing, Morral, Jordi, Hendrix, Chris, Herdewijn, Piet

“…A novel and facile synthesis of 5-hydroxy-4-hydroxymethyl-2-cyclohexenylguanine 1 is described. The key steps involve a Diels−Alder reaction of ethyl…”
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Enzymatic Incorporation in DNA of 1,5-Anhydrohexitol Nucleotides by Vastmans, Karen, Pochet, Sylvie, Peys, Annemie, Kerremans, Luc, Van Aerschot, Arthur, Hendrix, Chris, Marlière, Philippe, Herdewijn, Piet

“…The ability of several DNA polymerases to catalyze the template-directed synthesis of duplex oligonucleotides containing a base pair between a nucleotide with…”
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Molecular Dynamics Simulation To Investigate Differences in Minor Groove Hydration of HNA/RNA Hybrids As Compared to HNA/DNA Complexes by Winter, H. De, Lescrinier, E, Aerschot, A. Van, Herdewijn, P

“…Hexitol nucleic acids (HNA) are oligonucleotides built up from natural nucleobases and a phosphorylated 1,5-anhydrohexitol backbone. Molecular associations…”
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Antiviral activity of C-alkylated purine nucleosides obtained by cross-coupling with tetraalkyltin reagents by Van Aerschot, Arthur A, Mamos, Petros, Weyns, Nancy J, Ikeda, Satoru, De Clercq, Erik, Herdewijn, Piet A

“…2-, 6-, And 8-alkylated (methyl, ethyl, and vinyl) adenosine analogues were synthesized by a palladium-catalyzed cross-coupling of a tetraalkyltin with the…”
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