Search Results - "Herdemann, Matthias"

From a Biogenetic Scenario to a Synthesis of the ABC Ring of Manzamine A by Herdemann, Matthias, Al-Mourabit, Ali, Martin, Marie-Thérèse, Marazano, Christian

“…On the basis of a biogenetic proposal for explaining the biogenesis of manzamine A, the cycloaddition of dihydropyridinium salt 26 with diene derivative 5…”
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Identification of potent ITK inhibitors through focused compound library design including structural information by Herdemann, Matthias, Heit, Isabelle, Bosch, Frank-Uwe, Quintini, Gianluca, Scheipers, Claudia, Weber, Alexander

“…A series of novel compound libraries inhibiting interleukin-2 inducible T cell kinase (ITK) were designed, synthesized and evaluated. In the first design cycle…”
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Optimisation of ITK inhibitors through successive iterative design cycles by Herdemann, Matthias, Weber, Alexander, Jonveaux, Jérôme, Schwoebel, Frank, Stoeck, Michael, Heit, Isabelle

“…Based on a hit cluster of compounds inhibiting interleukin-2 inducible T-cell kinase (ITK) in the submicromolar range a series of ITK inhibitor libraries were…”
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Synthesis and biological evaluation of novel (4 or 5-aryl)pyrazolyl-indoles as inhibitors of interleukin-2 inducible T-cell kinase (ITK) by Velankar, Avdhoot D., Quintini, Gianluca, Prabhu, Arati, Weber, Alexander, Hunaeus, Gundula, Voland, Britta, Wuest, Monika, Orjeda, Christian, Harel, Dipak, Varghese, Shaji, Gore, Vikas, Patil, Meenal, Gayke, Deepak, Herdemann, Matthias, Heit, Isabelle, Zaliani, Andrea

“…Novel ITK inhibitors based on (4 or 5-aryl)pyrazolyl-indole scaffold were synthesized and were also found to be selective for ITK over other kinases like IRK,…”
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Reactions of Aminopentadienal Derivatives with 5,6-Dihydropyridinium Salts as an Approach to Manzamine Alkaloids Based upon Biogenetic Considerations by Jakubowicz, Karine, Abdeljelil, Kamel Ben, Herdemann, Matthias, Martin, Marie-Thérèse, Gateau-Olesker, Alice, Mourabit, Ali Al, Marazano, Christian, Das, Bhupesh C

“…Recent results from our laboratory have prompted us to introduce a modification of the original Baldwin proposal for the biosynthesis of manzamine alkaloids…”
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