Search Results - "Herbst, Martin"

Primary cilia regulate mTORC1 activity and cell size through Lkb1 by Kuehn, E. Wolfgang, Boehlke, Christopher, Kotsis, Fruzsina, Patel, Vishal, Braeg, Simone, Voelker, Henriette, Bredt, Saskia, Beyer, Theresa, Janusch, Heike, Hamann, Christoph, Gödel, Markus, Müller, Klaus, Herbst, Martin, Hornung, Miriam, Doerken, Mara, Köttgen, Michael, Nitschke, Roland, Igarashi, Peter, Walz, Gerd

“…The mTOR pathway is the central regulator of cell size. External signals from growth factors and nutrients converge on the mTORC1 multi-protein complex to…”
Get full text

Two independent killing mechanisms of Candida albicans by human neutrophils: evidence from innate immunity defects by Gazendam, Roel P., van Hamme, John L., Tool, AntonT.J., van Houdt, Michel, Verkuijlen, PaulJ.J.H., Herbst, Martin, Liese, Johannes G., van de Veerdonk, Frank L., Roos, Dirk, van den Berg, Timo K., Kuijpers, Taco W.

“…Invasive fungal infections, accompanied by high rates of mortality, represent an increasing problem in medicine. Neutrophils are the major effector immune…”
Get full text

Effect of heterogeneity on mechanical and micro-seismic behaviors of sandstone subjected to multi-level cyclic loading: A discrete element method investigation by Zhengyang Song, Zhen Yang, Min Zhang, Fei Wang, Martin Herbst, Heinz Konietzky

“…In numerical simulation of the mechanical responses and acoustic emission (AE) characteristics of rocks under cyclic loading, the impacts of compositional…”
Get full text

Some Thoughts about Infrared Radiation Response Characteristics during Loading of Sandstone Samples by Sun, Hai, Zhu, Hongyan, Konietzky, Heinz, Wang, Fei, Herbst, Martin

“…The infrared radiation response characteristics and mechanisms of sandstone samples under uniaxial compression were investigated using infrared thermal imaging…”
Get full text

A Protein Interaction Network Links GIT1, an Enhancer of Huntingtin Aggregation, to Huntington's Disease by Goehler, Heike, Lalowski, Maciej, Stelzl, Ulrich, Waelter, Stephanie, Stroedicke, Martin, Worm, Uwe, Droege, Anja, Lindenberg, Katrin S., Knoblich, Maria, Haenig, Christian, Herbst, Martin, Suopanki, Jaana, Scherzinger, Eberhard, Abraham, Claudia, Bauer, Bianca, Hasenbank, Renate, Fritzsche, Anja, Ludewig, Andreas H., Buessow, Konrad, Coleman, Sarah H., Gutekunst, Claire-Anne, Landwehrmeyer, Bernhard G., Lehrach, Hans, Wanker, Erich E.

“…Analysis of protein-protein interactions (PPIs) is a valuable approach for characterizing proteins of unknown function. Here, we have developed a strategy…”
Get full text

Therapeutic approaches to polyglutamine diseases: combating protein misfolding and aggregation by Herbst, Martin, Wanker, Erich E

“…Polyglutamine diseases are autosomal dominant, late-onset neurodegenerative disorders. Expansion of a polyglutamine (polyQ) tract above a threshold size leads…”
Get more information

Drawing mechanism of fractured top coal in longwall top coal caving by Song, Zhengyang, Konietzky, Heinz, Herbst, Martin

“…This work proposed a progressive-sectional failure model (PSFM) based on Particle Flow Code (PFC) to simulate top coal drawing process in longwall top coal…”
Get full text

Bonded-particle model-based simulation of artificial rock subjected to cyclic loading by Song, Zhengyang, Konietzky, Heinz, Herbst, Martin

“…A nonlinear parallel-bonded stress corrosion (NPSC) model is proposed to simulate the fatigue characteristics of artificial rock (concrete) during cyclic…”
Get full text

Three-dimensional particle model based numerical simulation on multi-level compressive cyclic loading of concrete by Song, Zhengyang, Konietzky, Heinz, Herbst, Martin

“…•MSC model is proposed to replicate multi-level cyclic loading results.•Damage variable is stress-time dependent in numerical model.•Damage variable is…”
Get full text

Influence of heterogeneity on thermo-mechanical behaviour of rocks by Wang, Fei, Konietzky, Heinz, Herbst, Martin

“…A new methodology combining Weibull functions and the real mineral composition of granite is proposed, which overcomes the shortcomings of using existing…”
Get full text

Brazilian tensile strength tests on some anisotropic rocks by Dan, Dinh Quoc, Konietzky, Heinz, Herbst, Martin

Get full text

A new continuum-based constitutive model for the simulation of the inherent anisotropy of Opalinus clay by Ismael, Mohamed, Konietzky, Heinz, Herbst, Martin

“…•A new continuum-based constitutive model called the Transubi model is introduced.•The model considers both the stiffness and the strength anisotropy of bedded…”
Get full text

Damage Evolution of Coal with Inclusions Under Triaxial Compression by Zhao, Yufeng, Konietzky, Heinz, Herbst, Martin

“…Along with the advance of the working face, coal experiences different loading stages. Laboratory tests and numerical simulations of fracture and damage…”
Get full text

Thermal effect of load platen stiffness during high-temperature rock-mechanical tests by Wang, Fei, Konietzky, Heinz, Herbst, Martin

“…The accuracy of rock property measurements in real-time heating loading tests has been considered as questionable due to the thermal effect on loading platens…”
Get full text

Cyclic Frictional Responses of Planar Joints Under Cyclic Normal Load Conditions: Laboratory Tests and Numerical Simulations by Dang, Wengang, Konietzky, Heinz, Frühwirt, Thomas, Herbst, Martin

“…An accurate quantification of the frictional behaviour of joints under cyclic normal load conditions during the cyclic shear process is important to…”
Get full text

Mechanical responses of grain-based models considering different crystallographic spatial distributions to simulate heterogeneous rocks under loading by Wang, Fei, Konietzky, Heinz, Herbst, Martin, Chen, Wei

“…Grain-based models (GBM) are widely used to reproduce the heterogeneous characteristics of natural rocks at the grain size level. To incorporate the spatial…”
Get full text

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers by Masino, Laura, Lurz, Rudi, Engemann, Sabine, Wanker, Erich E, Pastore, Annalisa, Boeddrich, Annett, Ehrnhoefer, Dagmar E, Bieschke, Jan, Herbst, Martin

“…The accumulation of β-sheet–rich amyloid fibrils or aggregates is a complex, multistep process that is associated with cellular toxicity in a number of human…”
Get full text

Fatigue and micro-seismic behaviors of concrete disks exposed to cyclic Brazilian testing: A numerical investigation based on a 3D particle-based model by Song, Zhengyang, Konietzky, Heinz, Herbst, Martin, Frühwirt, Thomas, Wu, Yunfeng

“…This article aims to numerically investigate the mechanical behaviour of concrete Brazilian Disk (BD) samples when exposed to multi-level cyclic Brazilian…”
Get full text

Numerical characterization of sandstone’s mechanical responses under multi-level compressive differential cyclic loading (DCL): A 3D particle-based numerical investigation by Song, Zhengyang, Yang, Zhen, Zhang, Min, Herbst, Martin, Dang, Wengang, Zhang, Tong

“…The mechanical response of rocks subjected to compressive differential cyclic loading (DCL) with various stress rates is rarely investigated via numerical…”
Get full text

Damage of irregular-shaped sandstone balusters under real fire loading by Wang, Fei, Konietzky, Heinz, Herbst, Martin

“…This study aims to use architectural sandstone balusters with a concave-convex geometry to investigate the potential influencing factors during…”
Get full text