Search Results - "Herbig, Utz"

AP-1 imprints a reversible transcriptional programme of senescent cells by Martínez-Zamudio, Ricardo Iván, Roux, Pierre-François, de Freitas, José Américo N.L.F., Robinson, Lucas, Doré, Gregory, Sun, Bin, Belenki, Dimitri, Milanovic, Maja, Herbig, Utz, Schmitt, Clemens A., Gil, Jesús, Bischof, Oliver

“…Senescent cells affect many physiological and pathophysiological processes. While select genetic and epigenetic elements for senescence induction have been…”
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The replicometer is broken: telomeres activate cellular senescence in response to genotoxic stresses by Suram, Anitha, Herbig, Utz

“…Summary Telomeres, the ends of our linear chromosomes, can function as ‘replicometers’, capable of counting cell division cycles as they progressively erode…”
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Cellular Senescence in Aging Primates by Herbig, Utz, Ferreira, Mark, Condel, Laura, Carey, Dee, Sedivy, John M

“…The aging of organisms is characterized by a gradual functional decline of all organ systems. Mammalian somatic cells in culture display a limited…”
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Telomeres and replicative cellular aging of the human placenta and chorioamniotic membranes by Lai, Tsung-Po, Simpson, Mark, Patel, Krunal, Verhulst, Simon, Noh, Jungsik, Roche, Natalie, Heller, Debra, Guirguis, George, Shay, Jerry W., Herbig, Utz, Aviv, Abraham

“…Recent hypotheses propose that the human placenta and chorioamniotic membranes (CAMs) experience telomere length (TL)-mediated senescence. These hypotheses are…”
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Accumulation of senescent cells in mitotic tissue of aging primates by Jeyapalan, Jessie C., Ferreira, Mark, Sedivy, John M., Herbig, Utz

“…Cellular senescence, a stress induced growth arrest of somatic cells, was first documented in cell cultures over 40 years ago, however its physiological…”
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Tracking and fixed ranking of leukocyte telomere length across the adult life course by Benetos, Athanase, Kark, Jeremy D., Susser, Ezra, Kimura, Masayuki, Sinnreich, Ronit, Chen, Wei, Steenstrup, Troels, Christensen, Kaare, Herbig, Utz, von Bornemann Hjelmborg, Jacob, Srinivasan, Sathanur R., Berenson, Gerald S., Labat, Carlos, Aviv, Abraham

“…Summary Short leukocyte telomere length (LTL) is associated with atherosclerosis in adults and diminished survival in the elderly. LTL dynamics are defined by…”
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Shorter telomere length in Europeans than in Africans due to polygenetic adaptation by Hansen, Matthew E B, Hunt, Steven C, Stone, Rivka C, Horvath, Kent, Herbig, Utz, Ranciaro, Alessia, Hirbo, Jibril, Beggs, William, Reiner, Alexander P, Wilson, James G, Kimura, Masayuki, De Vivo, Immaculata, Chen, Maxine M, Kark, Jeremy D, Levy, Daniel, Nyambo, Thomas, Tishkoff, Sarah A, Aviv, Abraham

“…Leukocyte telomere length (LTL), which reflects telomere length in other somatic tissues, is a complex genetic trait. Eleven SNPs have been shown in…”
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Telomerase gene therapy: a novel approach to combat aging by Boccardi, Virginia, Herbig, Utz

“…Partial or complete loss of telomerase function dramatically accelerates aging in mice and promotes aging associated disorders in humans. [...]the presence of…”
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BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping by Tarsounas, Madalena, Badie, Sophie, Escandell, Jose M, Bouwman, Peter, Carlos, Ana Rita, Thanasoula, Maria, Gallardo, Maria M, Suram, Anitha, Jaco, Isabel, Benitez, Javier, Herbig, Utz, Blasco, Maria A, Jonkers, Jos

“…Mutations in BRCA2 are associated with higher susceptibility to some forms of cancer. BRCA2 is known to play a central role in the repair of DNA breaks via…”
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Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology by Levy, Daniel, Neuhausen, Susan L, Hunt, Steven C, Kimura, Masayuki, Hwang, Shih-Jen, Chen, Wei, Bis, Joshua C, Fitzpatrick, Annette L, Smith, Erin, Johnson, Andrew D, Gardner, Jeffrey P, Srinivasan, Sathanur R, Schork, Nicholas, Rotter, Jerome I, Herbig, Utz, Psaty, Bruce M, Sastrasinh, Malinee, Murray, Sarah S, Vasan, Ramachandran S, Province, Michael A, Glazer, Nicole L, Lu, Xiaobin, Cao, Xiaojian, Kronmal, Richard, Mangino, Massimo, Soranzo, Nicole, Spector, Tim D, Berenson, Gerald S, Aviv, Abraham

“…Telomeres are engaged in a host of cellular functions, and their length is regulated by multiple genes. Telomere shortening, in the course of somatic cell…”
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Author Correction: AP-1 imprints a reversible transcriptional programme of senescent cells by Martínez-Zamudio, Ricardo Iván, Roux, Pierre-François, de Freitas, José Américo N.L.F., Robinson, Lucas, Doré, Gregory, Sun, Bin, Belenki, Dimitri, Milanovic, Maja, Herbig, Utz, Schmitt, Clemens A., Gil, Jesús, Bischof, Oliver

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Stn1 is critical for telomere maintenance and long‐term viability of somatic human cells by Boccardi, Virginia, Razdan, Neetu, Kaplunov, Jessica, Mundra, Jyoti J., Kimura, Masayuki, Aviv, Abraham, Herbig, Utz

“…Summary Disruption of telomere maintenance pathways leads to accelerated entry into cellular senescence, a stable proliferative arrest that promotes…”
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Expression of (NES-)hTERT in cancer cells delays cell cycle progression and increases sensitivity to genotoxic stress by Kovalenko, Olga A, Kaplunov, Jessica, Herbig, Utz, Detoledo, Sonia, Azzam, Edouard I, Santos, Janine H

“…Telomerase is a reverse transcriptase associated with cellular immortality through telomere maintenance. This enzyme is activated in 90% of human cancers, and…”
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Expression of NES-hTERT in Cancer Cells Delays Cell Cycle Progression and Increases Sensitivity to Genotoxic Stress by Kovalenko, Olga A., Kaplunov, Jessica, Herbig, Utz, deToledo, Sonia, Azzam, Edouard I., Santos, Janine H.

“…Telomerase is a reverse transcriptase associated with cellular immortality through telomere maintenance. This enzyme is activated in 90% of human cancers, and…”
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Telomere dysfunction promotes transdifferentiation of human fibroblasts into myofibroblasts by Razdan, Neetu, Vasilopoulos, Themistoklis, Herbig, Utz

“…Cells that had undergone telomere dysfunction‐induced senescence secrete numerous cytokines and other molecules, collectively called the senescence‐associated…”
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Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells by Benhamed, Moussa, Herbig, Utz, Ye, Tao, Dejean, Anne, Bischof, Oliver

“…Cellular senescence is a tumour-suppressor mechanism that is triggered by cancer-initiating or promoting events in mammalian cells. The molecular underpinnings…”
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Cellular senescence, p21, and the path to fibrosis by Turano, Paolo S, Herbig, Utz

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Derepression of hTERT gene expression promotes escape from oncogene-induced cellular senescence by Patel, Priyanka L., Suram, Anitha, Mirani, Neena, Bischof, Oliver, Herbig, Utz

“…Oncogene-induced senescence (OIS) is a critical tumor-suppressing mechanism that restrains cancer progression at premalignant stages, in part by causing…”
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Real‐time imaging of transcriptional activation in live cells reveals rapid up‐regulation of the cyclin‐dependent kinase inhibitor gene CDKN1A in replicative cellular senescence by Herbig, Utz, Wei, Wenyi, Dutriaux, Annie, Jobling, Wendy A., Sedivy, John M.

“…Summary Cellular replicative senescence is a permanent growth arrest state that can be triggered by telomere shortening. The cyclin‐dependent kinase (Cdk)…”
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Two Regions of Simian Virus 40 T Antigen Determine Cooperativity of Double-Hexamer Assembly on the Viral Origin of DNA Replication and Promote Hexamer Interactions during Bidirectional Origin DNA Unwinding by Weisshart, K, Taneja, P, Jenne, A, Herbig, U, Simmons, D T, Fanning, E

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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