Search Results - "Herberg, Friedrich W."

LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains by Weng, Jui-Hung, Aoto, Phillip C, Lorenz, Robin, Wu, Jian, Schmidt, Sven H, Manschwetus, Jascha T, Kaila-Sharma, Pallavi, Silletti, Steve, Mathea, Sebastian, Chatterjee, Deep, Knapp, Stefan, Herberg, Friedrich W, Taylor, Susan S

“…The 2 major molecular switches in biology, kinases and GTPases, are both contained in the Parkinson disease-related leucine-rich repeat kinase 2 (LRRK2). Using…”
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Microtubule-Associated Serine/Threonine (MAST) Kinases in Development and Disease by Rumpf, Marie, Pautz, Sabine, Drebes, Benedikt, Herberg, Friedrich W, Müller, Hans-Arno J

“…Microtubule-Associated Serine/Threonine (MAST) kinases represent an evolutionary conserved branch of the AGC protein kinase superfamily in the kinome. Since…”
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Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3 by Muda, Kathrin, Bertinetti, Daniela, Gesellchen, Frank, Hermann, Jennifer Sarah, von Zweydorf, Felix, Geerlof, Arie, Jacob, Anette, Ueffing, Marius, Gloeckner, Christian Johannes, Herberg, Friedrich W

“…Leucine-rich repeat kinase 2 (LRRK2) is a multidomain protein implicated in Parkinson disease (PD); however, the molecular mechanism and mode of action of this…”
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Inhibitors and fluorescent probes for protein kinase PKAcβ and its S54L mutant, identified in a patient with cortisol producing adenoma by Nonga, Olivier Etebe, Enkvist, Erki, Herberg, Friedrich W., Uri, Asko

“…Recently, a mutation was discovered in the gene PRKACB encoding the catalytic subunit β of PKA (PKAcβ) from a patient with severe Cushing's syndrome. This…”
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Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2 by Singh, Ranjan K, Soliman, Ahmed, Guaitoli, Giambattista, Störmer, Eliza, von Zweydorf, Felix, Dal Maso, Thomas, Oun, Asmaa, Van Rillaer, Laura, Schmidt, Sven H, Chatterjee, Deep, David, Joshua A, Pardon, Els, Schwartz, Thomas U, Knapp, Stefan, Kennedy, Eileen J, Steyaert, Jan, Herberg, Friedrich W, Kortholt, Arjan, Gloeckner, Christian Johannes, Versées, Wim

“…Mutations in the gene coding for leucine-rich repeat kinase 2 (LRRK2) are a leading cause of the inherited form of Parkinson's disease (PD), while LRRK2…”
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The PKG Inhibitor CN238 Affords Functional Protection of Photoreceptors and Ganglion Cells against Retinal Degeneration by Tolone, Arianna, Haq, Wadood, Fachinger, Alexandra, Roy, Akanksha, Kesh, Sandeep, Rentsch, Andreas, Wucherpfennig, Sophie, Zhu, Yu, Groten, John, Schwede, Frank, Tomar, Tushar, Herberg, Friedrich W, Nache, Vasilica, Paquet-Durand, François

“…Hereditary retinal degeneration (RD) is often associated with excessive cGMP signalling in photoreceptors. Previous research has shown that inhibition of…”
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Tetramerization Dynamics of C-terminal Domain Underlies Isoform-specific cAMP Gating in Hyperpolarization-activated Cyclic Nucleotide-gated Channels by Lolicato, Marco, Nardini, Marco, Gazzarrini, Sabrina, Möller, Stefan, Bertinetti, Daniela, Herberg, Friedrich W., Bolognesi, Martino, Martin, Holger, Fasolini, Marina, Bertrand, Jay A., Arrigoni, Cristina, Thiel, Gerhard, Moroni, Anna

“…Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are dually activated by hyperpolarization and binding of cAMP to their cyclic nucleotide…”
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Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies by Chaikuad, Apirat, Keates, Tracy, Vincke, Cécile, Kaufholz, Melanie, Zenn, Michael, Zimmermann, Bastian, Gutiérrez, Carlos, Zhang, Rong-Guang, Hatzos-Skintges, Catherine, Joachimiak, Andrzej, Muyldermans, Serge, Herberg, Friedrich W, Knapp, Stefan, Müller, Susanne

“…GAK (cyclin G-associated kinase) is a key regulator of clathrin-coated vesicle trafficking and plays a central role during development. Additionally, due to…”
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Binding of the Human 14-3-3 Isoforms to Distinct Sites in the Leucine-Rich Repeat Kinase 2 by Manschwetus, Jascha T, Wallbott, Maximilian, Fachinger, Alexandra, Obergruber, Claudia, Pautz, Sabine, Bertinetti, Daniela, Schmidt, Sven H, Herberg, Friedrich W

“…Proteins of the 14-3-3 family are well known modulators of the leucine-rich repeat kinase 2 (LRRK2) regulating kinase activity, cellular localization, and…”
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Structural and functional analysis of phosphorylation-specific binders of the kinase ERK from designed ankyrin repeat protein libraries by Kummer, Lutz, Parizek, Petra, Rube, Peter, Millgramm, Bastian, Prinz, Anke, Mittl, Peer R. E, Kaufholz, Melanie, Zimmermann, Bastian, Herberg, Friedrich W, Plückthun, Andreas

“…We have selected designed ankyrin repeat proteins (DARPins) from a synthetic library by using ribosome display that selectively bind to the mitogen-activated…”
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Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I by Huang, Gilbert Y., Kim, Jeong Joo, Reger, Albert S., Lorenz, Robin, Moon, Eui-Whan, Zhao, Chi, Casteel, Darren E., Bertinetti, Daniela, VanSchouwen, Bryan, Selvaratnam, Rajeevan, Pflugrath, James W., Sankaran, Banumathi, Melacini, Giuseppe, Herberg, Friedrich W., Kim, Choel

“…Cyclic guanosine monophosphate (cGMP) and cyclic AMP (cAMP)-dependent protein kinases (PKG and PKA) are closely related homologs, and the cyclic nucleotide…”
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Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation by Kim, Jeong Joo, Lorenz, Robin, Arold, Stefan T., Reger, Albert S., Sankaran, Banumathi, Casteel, Darren E., Herberg, Friedrich W., Kim, Choel

“…Cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) is a key regulator of smooth muscle and vascular tone and represents an important drug…”
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Structure-guided design of selective Epac1 and Epac2 agonists by Schwede, Frank, Bertinetti, Daniela, Langerijs, Carianne N, Hadders, Michael A, Wienk, Hans, Ellenbroek, Johanne H, de Koning, Eelco J P, Bos, Johannes L, Herberg, Friedrich W, Genieser, Hans-Gottfried, Janssen, Richard A J, Rehmann, Holger

“…The second messenger cAMP is known to augment glucose-induced insulin secretion. However, its downstream targets in pancreatic β-cells have not been…”
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Mutations of PKA cyclic nucleotide-binding domains reveal novel aspects of cyclic nucleotide selectivity by Lorenz, Robin, Moon, Eui-Whan, Kim, Jeong Joo, Schmidt, Sven H, Sankaran, Banumathi, Pavlidis, Ioannis V, Kim, Choel, Herberg, Friedrich W

“…Cyclic AMP and cyclic GMP are ubiquitous second messengers that regulate the activity of effector proteins in all forms of life. The main effector proteins,…”
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AKAP18:PKA-RIIα structure reveals crucial anchor points for recognition of regulatory subunits of PKA by Götz, Frank, Roske, Yvette, Schulz, Maike Svenja, Autenrieth, Karolin, Bertinetti, Daniela, Faelber, Katja, Zühlke, Kerstin, Kreuchwig, Annika, Kennedy, Eileen J, Krause, Gerd, Daumke, Oliver, Herberg, Friedrich W, Heinemann, Udo, Klussmann, Enno

“…A-kinase anchoring proteins (AKAPs) interact with the dimerization/docking (D/D) domains of regulatory subunits of the ubiquitous protein kinase A (PKA). AKAPs…”
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An auto-inhibited state of protein kinase G and implications for selective activation by Sharma, Rajesh, Kim, Jeong Joo, Qin, Liying, Henning, Philipp, Akimoto, Madoka, VanSchouwen, Bryan, Kaur, Gundeep, Sankaran, Banumathi, MacKenzie, Kevin R, Melacini, Giuseppe, Casteel, Darren E, Herberg, Friedrich W, Kim, Choel

“…Cyclic GMP-dependent protein kinases (PKGs) are key mediators of the nitric oxide/cyclic guanosine monophosphate (cGMP) signaling pathway that regulates…”
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Kinase Domain Is a Dynamic Hub for Driving LRRK2 Allostery by Taylor, Susan S., Kaila-Sharma, Pallavi, Weng, Jui-Hung, Aoto, Phillip, Schmidt, Sven H., Knapp, Stefan, Mathea, Sebastian, Herberg, Friedrich W.

“…Protein kinases and GTPases are the two major molecular switches that regulate much of biology, and both of these domains are embedded within the large…”
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A Stapled Peptide Mimic of the Pseudosubstrate Inhibitor PKI Inhibits Protein Kinase A by Manschwetus, Jascha T, Bendzunas, George N, Limaye, Ameya J, Knape, Matthias J, Herberg, Friedrich W, Kennedy, Eileen J

“…Kinases regulate multiple and diverse signaling pathways and misregulation is implicated in a multitude of diseases. Although significant efforts have been put…”
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cAMP-Dependent Signaling Pathways as Potential Targets for Inhibition of Plasmodium falciparum Blood Stages by Lasonder, Edwin, More, Kunal, Singh, Shailja, Haidar, Malak, Bertinetti, Daniela, Kennedy, Eileen J., Herberg, Friedrich W., Holder, Anthony A., Langsley, Gordon, Chitnis, Chetan E.

“…We review the role of signaling pathways in regulation of the key processes of merozoite egress and red blood cell invasion by Plasmodium falciparum and, in…”
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Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme by Zhang, Ping, Knape, Matthias J, Ahuja, Lalima G, Keshwani, Malik M, King, Charles C, Sastri, Mira, Herberg, Friedrich W, Taylor, Susan S

“…To provide tight spatiotemporal signaling control, the cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) holoenzyme typically nucleates a…”
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