Search Results - "Herb, Brian"

Biological insights from multi-omic analysis of 31 genomic risk loci for adult hearing difficulty by Kalra, Gurmannat, Milon, Beatrice, Casella, Alex M, Herb, Brian R, Humphries, Elizabeth, Song, Yang, Rose, Kevin P, Hertzano, Ronna, Ament, Seth A

“…Age-related hearing impairment (ARHI), one of the most common medical conditions, is strongly heritable, yet its genetic causes remain largely unknown. We…”
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A single-cell genomic atlas for maturation of the human cerebellum during early childhood by Ament, Seth A, Cortes-Gutierrez, Marcia, Herb, Brian R, Mocci, Evelina, Colantuoni, Carlo, McCarthy, Margaret M

“…Inflammation early in life is a clinically established risk factor for autism spectrum disorders and schizophrenia, yet the impact of inflammation on human…”
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Leptin-activated hypothalamic BNC2 neurons acutely suppress food intake by Tan, Han L, Yin, Luping, Tan, Yuqi, Ivanov, Jessica, Plucinska, Kaja, Ilanges, Anoj, Herb, Brian R, Wang, Putianqi, Kosse, Christin, Cohen, Paul, Lin, Dayu, Friedman, Jeffrey M

“…Leptin is an adipose tissue hormone that maintains homeostatic control of adipose tissue mass by regulating the activity of specific neural populations…”
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Defense against territorial intrusion is associated with DNA methylation changes in the honey bee brain by Herb, Brian R, Shook, Molly S, Fields, Christopher J, Robinson, Gene E

“…Aggression is influenced by individual variation in temperament as well as behavioral plasticity in response to adversity. DNA methylation is stably maintained…”
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Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts by Daley, George Q, Feinberg, Andrew P, Doi, Akiko, Park, In-Hyun, Wen, Bo, Murakami, Peter, Aryee, Martin J, Irizarry, Rafael, Herb, Brian, Ladd-Acosta, Christine, Rho, Junsung, Loewer, Sabine, Miller, Justine, Schlaeger, Thorsten

“…Andrew Feinberg and colleagues show that differential methylation of CpG island shores distinguish human induced pluripotent stem cells from the fibroblasts…”
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MAMS: matrix and analysis metadata standards to facilitate harmonization and reproducibility of single-cell data by Sarfraz, Irzam, Wang, Yichen, Shastry, Amulya, Teh, Wei Kheng, Sokolov, Artem, Herb, Brian R, Creasy, Heather H, Virshup, Isaac, Dries, Ruben, Degatano, Kylee, Mahurkar, Anup, Schnell, Daniel J, Madrigal, Pedro, Hilton, Jason, Gehlenborg, Nils, Tickle, Timothy, Campbell, Joshua D

“…Many datasets are being produced by consortia that seek to characterize healthy and disease tissues at single-cell resolution. While biospecimen and…”
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Single-Nucleus RNA-Seq Reveals Dysregulation of Striatal Cell Identity Due to Huntington's Disease Mutations by Malaiya, Sonia, Cortes-Gutierrez, Marcia, Herb, Brian R, Coffey, Sydney R, Legg, Samuel R W, Cantle, Jeffrey P, Colantuoni, Carlo, Carroll, Jeffrey B, Ament, Seth A

“…Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by a trinucleotide expansion in exon 1 of the huntingtin ( ) gene. Cell…”
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Cochlear organoids reveal transcriptional programs of postnatal hair cell differentiation from supporting cells by Kalra, Gurmannat, Lenz, Danielle, Abdul-Aziz, Dunia, Hanna, Craig, Basu, Mahashweta, Herb, Brian R., Colantuoni, Carlo, Milon, Beatrice, Saxena, Madhurima, Shetty, Amol C., Hertzano, Ronna, Shivdasani, Ramesh A., Ament, Seth A., Edge, Albert S.B.

“…We explore the changes in chromatin accessibility and transcriptional programs for cochlear hair cell differentiation from postmitotic supporting cells using…”
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The Neuroscience Multi-Omic Archive: a BRAIN Initiative resource for single-cell transcriptomic and epigenomic data from the mammalian brain by Ament, Seth A, Adkins, Ricky S, Carter, Robert, Chrysostomou, Elena, Colantuoni, Carlo, Crabtree, Jonathan, Creasy, Heather H, Degatano, Kylee, Felix, Victor, Gandt, Peter, Garden, Gwenn A, Giglio, Michelle, Herb, Brian R, Khajouei, Farzaneh, Kiernan, Elizabeth, McCracken, Carrie, McDaniel, Kennedy, Nadendla, Suvarna, Nickel, Lance, Olley, Dustin, Orvis, Joshua, Receveur, Joseph P, Schor, Mike, Sonthalia, Shreyash, Tickle, Timothy L, Way, Jessica, Hertzano, Ronna, Mahurkar, Anup A, White, Owen R

“…Scalable technologies to sequence the transcriptomes and epigenomes of single cells are transforming our understanding of cell types and cell states. The Brain…”
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Epigenetics as an answer to Darwin's "special difficulty" by Herb, Brian R

“…Epigenetic modifications produce distinct phenotypes from the same genome through genome-wide transcriptional control. Recently, DNA methylation in honeybees…”
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Reversible switching between epigenetic states in honeybee behavioral subcastes by Herb, Brian R, Wolschin, Florian, Hansen, Kasper D, Aryee, Martin J, Langmead, Ben, Irizarry, Rafael, Amdam, Gro V, Feinberg, Andrew P

“…This paper reports that there are substantial differences in DNA methylation patterns between nurses and forager caste phenotypes in honeybees, and that…”
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Single-cell genomics reveals region-specific developmental trajectories underlying neuronal diversity in the human hypothalamus by Herb, Brian R, Glover, Hannah J, Bhaduri, Aparna, Colantuoni, Carlo, Bale, Tracy L, Siletti, Kimberly, Hodge, Rebecca, Lein, Ed, Kriegstein, Arnold R, Doege, Claudia A, Ament, Seth A

“…The development and diversity of neuronal subtypes in the human hypothalamus has been insufficiently characterized. To address this, we integrated…”
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Adaptation of the CHARM DNA methylation platform for the rat genome reveals novel brain region-specific differences by Lee, Richard S., Tamashiro, Kellie L.K., Aryee, Martin J., Murakami, Peter, Seifuddin, Fayaz, Herb, Brian, Huo, Yuqing, Rongione, Michael, Feinberg, Andrew P., Moran, Timothy H., Potash, James B.

“…Comprehensive High-throughput Arrays for Relative Methylation (CHARM) was recently developed as an experimental platform and analytic approach to assess DNA…”
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A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex by Yao, Zizhen, Liu, Hanqing, Xie, Fangming, Fischer, Stephan, Adkins, Ricky S., Aldridge, Andrew I., Ament, Seth A., Bartlett, Anna, Behrens, M. Margarita, Van den Berge, Koen, Bertagnolli, Darren, de Bézieux, Hector Roux, Biancalani, Tommaso, Booeshaghi, A. Sina, Bravo, Héctor Corrada, Casper, Tamara, Colantuoni, Carlo, Crabtree, Jonathan, Creasy, Heather, Crichton, Kirsten, Crow, Megan, Dee, Nick, Dougherty, Elizabeth L., Doyle, Wayne I., Dudoit, Sandrine, Fang, Rongxin, Felix, Victor, Fong, Olivia, Giglio, Michelle, Goldy, Jeff, Hawrylycz, Mike, Herb, Brian R., Hertzano, Ronna, Hou, Xiaomeng, Hu, Qiwen, Kancherla, Jayaram, Kroll, Matthew, Lathia, Kanan, Li, Yang Eric, Lucero, Jacinta D., Luo, Chongyuan, Mahurkar, Anup, McMillen, Delissa, Nadaf, Naeem M., Nery, Joseph R., Nguyen, Thuc Nghi, Niu, Sheng-Yong, Ntranos, Vasilis, Orvis, Joshua, Osteen, Julia K., Pham, Thanh, Pinto-Duarte, Antonio, Poirion, Olivier, Preissl, Sebastian, Purdom, Elizabeth, Rimorin, Christine, Risso, Davide, Rivkin, Angeline C., Smith, Kimberly, Street, Kelly, Sulc, Josef, Svensson, Valentine, Tieu, Michael, Torkelson, Amy, Tung, Herman, Vaishnav, Eeshit Dhaval, Vanderburg, Charles R., van Velthoven, Cindy, Wang, Xinxin, White, Owen R., Huang, Z. Josh, Kharchenko, Peter V., Pachter, Lior, Ngai, John, Regev, Aviv, Tasic, Bosiljka, Welch, Joshua D., Gillis, Jesse, Macosko, Evan Z., Ren, Bing, Ecker, Joseph R., Zeng, Hongkui, Mukamel, Eran A.

“…Single-cell transcriptomics can provide quantitative molecular signatures for large, unbiased samples of the diverse cell types in the brain 1 – 3 . With the…”
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gEAR: Gene Expression Analysis Resource portal for community-driven, multi-omic data exploration by Orvis, Joshua, Gottfried, Brian, Kancherla, Jayaram, Adkins, Ricky S., Song, Yang, Dror, Amiel A., Olley, Dustin, Rose, Kevin, Chrysostomou, Elena, Kelly, Michael C., Milon, Beatrice, Matern, Maggie S., Azaiez, Hela, Herb, Brian, Colantuoni, Carlo, Carter, Robert L., Ament, Seth A., Kelley, Matthew W., White, Owen, Bravo, Hector Corrada, Mahurkar, Anup, Hertzano, Ronna

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Juvenile hormone regulates brain-reproduction tradeoff in bumble bees but not in honey bees by Shpigler, Hagai Y., Herb, Brian, Drnevich, Jenny, Band, Mark, Robinson, Gene E., Bloch, Guy

“…Gonadotropic hormones coordinate processes in diverse tissues regulating animal reproductive physiology and behavior. Juvenile hormone (JH) is the ancient and…”
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SINGLE-CELL GENOMICS REVEALS EFFECTS OF CHILDHOOD INFLAMMATION DURING THE POSTNATAL MATURATION OF THE HUMAN CEREBELLUM by Ament, Seth, Arambula, Sheryl, Cortes-Gutierrez, Marcia, Herb, Brian, Mocci, Evelina, Colantuoni, Carlo, McCarthy, Margaret

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Incidence and predictors of hypertension in adults with HIV-initiating antiretroviral therapy in south-western Uganda by Okello, Samson, Kanyesigye, Michael, Muyindike, Winnie R, Annex, Brian Herb, Hunt, Peter W, Haneuse, Sebastien, Siedner, Mark Jacob

“…The successful scale-up of antiretroviral therapy (ART) in sub-Saharan Africa has led to increasing life expectancy, and thus increased risk of hypertension…”
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Epigenetics as an answer to Darwin’s “special difficultyâ by Herb, Brian R.

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Transcriptional signatures of fentanyl use in the mouse ventral tegmental area by Fox, Megan E., Montemarano, Annalisa, Ostman, Alexandria E., Basu, Mahashweta, Herb, Brian, Ament, Seth A., Fox, Logan D.

“…Synthetic opioids such as fentanyl contribute to the vast majority of opioid‐related overdose deaths, but fentanyl use remains broadly understudied. Like other…”
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