Search Results - "Herault, J P"

Soluble HLA-G1 inhibits angiogenesis through an apoptotic pathway and by direct binding to CD160 receptor expressed by endothelial cells by Fons, Pierre, Chabot, Sophie, Cartwright, Judith E., Lenfant, Francoise, L'Faqihi, Fatima, Giustiniani, Jerome, Herault, Jean-Pascal, Gueguen, Genevieve, Bono, Françoise, Savi, Pierre, Aguerre-Girr, Maryse, Fournel, Sylvie, Malecaze, François, Bensussan, Armand, Plouët, Jean, Le Bouteiller, Philippe

“…HLA-G is a major histocompatibility complex class Ib molecule whose constitutive tissue distribution is restricted mainly to trophoblast cells at the…”
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Apelin/APJ signaling system: a potential link between adipose tissue and endothelial angiogenic processes by Kunduzova, O, Alet, N, Delesque-Touchard, N, Millet, L, Castan-Laurell, I, Muller, C, Dray, C, Schaeffer, P, Herault, J.P, Savi, P, Bono, F, Valet, P

“…Adipose tissue is an active endocrine organ that produces a variety of secretory factors involved in the initiation of angiogenic processes. The bioactive…”
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Synthesis of thrombin-inhibiting heparin mimetics without side effects by Herbert, Jean-Marc, Petitou, Maurice, Hérault, Jean-Pascal, Bernat, André, Driguez, Pierre-Alexandre, Duchaussoy, Philippe, Lormeau, Jean-Claude

“…Unwanted side effects of pharmacologically active compounds can usually be eliminated by structural modifications. But the complex heterogeneous structure of…”
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Contribution of erythrocytes to thrombin generation in whole blood by Peyrou, V, Lormeau, J C, Hérault, J P, Gaich, C, Pfliegger, A M, Herbert, J M

“…Thrombin generation (TG) initiated by diluted tissue-factor was investigated in whole human blood, in platelet-rich plasma (PRP), in platelet-poor plasma…”
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SR123781A, a synthetic heparin mimetic by Herbert, J M, Hérault, J P, Bernat, A, Savi, P, Schaeffer, P, Driguez, P A, Duchaussoy, P, Petitou, M

“…SR123781A, a synthetic hexadecasaccharide comprising an antithrombin (AT) binding domain, a thrombin binding domain, and a neutral methylated hexasaccharide…”
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The effect of the synthetic pentasaccharide SR 90107/ORG 31540 on thrombin generation ex vivo is uniquely due to ATIII-mediated neutralization of factor Xa by Lormeau, J C, Herault, J P

“…The inhibition of thrombin generation (TG) was studied in plasma from human volunteers after single subcutaneous administrations of 4000, 8000 or 12,000…”
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Effect of SR121566A, a potent GP IIb-IIIa antagonist on platelet-mediated thrombin generation in vitro and in vivo by Herault, J P, Peyrou, V, Savi, P, Bernat, A, Herbert, J M

“…The effect of SR121566A, a new non-peptide GP IIb-IIIa antagonist was studied in vitro with regard to thrombin generation in platelet rich plasma and in vivo…”
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The structure of synthetic oligosaccharides in relation to factor IXa inhibition by Hérault, J P, Gaich, C, Bono, F, Driguez, P A, Duchaussoy, P, Petitou, M, Herbert, J M

“…We investigated the effect of various oligosaccharides (OS) on the inhibition of factor IXa by antithrombin (AT) in a purified system. The OS comprised the…”
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Biochemical and Pharmacological Properties of SANORG 32701: Comparison With the `Synthetic Pentasaccharide' (SR 90107/ORG 31540) and Standard Heparin by Herbert, J.M, Herault, J.P, Bernat, A, van Amsterdam, R.G.M, Vogel, G.M.T, Lormeau, J.C, Petitou, M, Meuleman, D.G

“…SANORG 32701 is a new sulfated pentasaccharide obtained by total chemical synthesis. It is an analogue of the ``synthetic pentasaccharide'' (SR 90107/ORG…”
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Effect of new synthetic heparin mimetics on whole blood thrombin generation in vivo and in vitro in rats by Hérault, J P, Bernat, A, Gaich, C, Herbert, M

“…The effect of new heparin mimetics (synthetic oligosaccharides) was studied in vitro with regard to thrombin generation (TG) in rat platelet rich plasma (PRP)…”
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Reversible biotinylated oligosaccharides: a new approach for a better management of anticoagulant therapy by SAVI, P., HERAULT, J. P., DUCHAUSSOY, P., MILLET, L., SCHAEFFER, P., PETITOU, M., BONO, F., HERBERT, J. M.

“…Objective: In order to obtain a neutralizable antithrombotic, a chimeric molecule (SSR126517E) containing the sequence of a long‐lasting antithrombin…”
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Effect of factor Xa inhibitors on the platelet-derived microparticles procoagulant activity in vitro and in vivo in rats by Hérault, J P, Perrin, B, Jongbloet, C, Pflieger, A M, Bernat, A, Herbert, J M

“…The aim of this study was to investigate the effect of factor Xa inhibitors on the prothrombinase activity of platelet-derived microparticles in vitro and in…”
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Activity of a synthetic hexadecasaccharide (SanOrg123781A) in a pig model of arterial thrombosis by Bal dit Sollier, C, Kang, C, Berge, N, Herault, J P, Bonneau, M, Herbert, J M, Drouet, L

“…The activity of SanOrg123781A, a new synthetic antithrombotic drug inhibiting both factor Xa and thrombin through antithrombin (AT), was compared to that of…”
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Anti-thrombotic effect of a synthetic heparin mimetic in an arterial model of thrombosis in rats: comparison with unfractionated heparin and nadroparin by Leger, P, Cambus, J P, Herault, J P, Herbert, J M, Boneu, B

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Effects of a new platelet glycoprotein IIb/IIIa antagonist, SR121566, on platelet activation, platelet-leukocyte interaction and thrombin generation by Li, N, Wallén, N H, Savi, P, Hérault, J P, Herbert, J M

“…The effects of SR121566, a new inhibitor of the glycoprotein (GP) IIb/IIIa complex on platelet activation and platelet-leukocyte interactions, as well as on…”
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Comparative inhibition of extrinsic and intrinsic thrombin generation by standard heparin, a low molecular weight heparin and the synthetic ATIII-binding pentasaccharide by Lormeau, J C, Herault, J P

“…The inhibiting effect of standard heparin, CY216 and the ATIII-binding synthetic pentasaccharide on extrinsic and intrinsic thrombin generation were quantified…”
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Activation of human vascular endothelial cells by factor Xa: effect of specific inhibitors by Herault, Jean-Pascal, Bono, Françoise, Avril, Corinne, Schaeffer, Paul, Herbert, Jean-Marc

“…Recently, human umbilical vein endothelial cells (HUVEC) have been shown to express functional high-affinity receptors for factor Xa, which may be of…”
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THE SYNTHETIC PENTASACCHARIDE SR 90107A/ORG 31540 DOES NOT RELEASE LIPASE ACTIVITY INTO THE PLASMA by Hoffmann, P, Bernat, A, Dumas, A, Petitou, M, Hérault, J.P, Herbert, J.M

“…The present study was designed to find out whether the synthetic pentasaccharide SR 90107A/Org 31540, which is presently being evaluated in clinical trials as…”
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Effect of clopidogrel on thrombin generation in platelet-rich plasma in the rat by Hérault, J P, Dol, F, Gaich, C, Bernat, A, Herbert, J M

“…Clopidogrel (25 mg/kg, p.o.), a potent and selective inhibitor of ADP-induced platelet aggregation, significantly inhibited, in the presence of platelets, ex…”
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Long-term persistence of low-molecular-weight material with anti-factor Xa activity contributes to anticoagulant and antithrombotic effects after subcutaneous injection of CY 216 in the rabbit by Peyrou, V, Lormeau, J C, Hérault, J P, Boneu, B, Herbert, J M

“…This study was done to document further the mechanism of the antithrombotic effect of CY 216 after subcutaneous injection in the rabbit. We first measured the…”
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