Search Results - "Herati, Ramin Sedaghat"

Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells by Bengsch, Bertram, Ohtani, Takuya, Khan, Omar, Setty, Manu, Manne, Sasikanth, O’Brien, Shaun, Gherardini, Pier Federico, Herati, Ramin Sedaghat, Huang, Alexander C., Chang, Kyong-Mi, Newell, Evan W., Bovenschen, Niels, Pe’er, Dana, Albelda, Steven M., Wherry, E. John

“…Exhausted CD8 T (Tex) cells are immunotherapy targets in chronic infection and cancer, but a comprehensive assessment of Tex cell diversity in human disease is…”
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Robust immune responses are observed after one dose of BNT162b2 mRNA vaccine dose in SARS-CoV-2-experienced individuals by Samanovic, Marie I, Cornelius, Amber R, Gray-Gaillard, Sophie L, Allen, Joseph Richard, Karmacharya, Trishala, Wilson, Jimmy P, Hyman, Sara Wesley, Tuen, Michael, Koralov, Sergei B, Mulligan, Mark J, Herati, Ramin Sedaghat

“…The use of coronavirus disease 2019 (COVID-19) vaccines will play the major role in helping to end the pandemic that has killed millions worldwide. COVID-19…”
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SARS-CoV-2 vaccines for all but a single dose for COVID-19 survivors by Frieman, Matthew, Harris, Anthony D., Herati, Ramin Sedaghat, Krammer, Florian, Mantovani, Alberto, Rescigno, Maria, Sajadi, Mohammad M., Simon, Viviana

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Vaccine-induced ICOS+CD38+ circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways by Herati, Ramin Sedaghat, Silva, Luisa Victoria, Vella, Laura A., Muselman, Alexander, Alanio, Cecile, Bengsch, Bertram, Kurupati, Raj K., Kannan, Senthil, Manne, Sasikanth, Kossenkov, Andrew V., Canaday, David H., Doyle, Susan A., Ertl, Hildegund C.J., Schmader, Kenneth E., Wherry, E. John

“…Humoral immune responses are dysregulated with aging, but the cellular and molecular pathways involved remain incompletely understood. In particular, little is…”
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Vaccine-Acquired SARS-CoV-2 Immunity versus Infection-Acquired Immunity: A Comparison of Three COVID-19 Vaccines by Samanovic, Marie I, Oom, Aaron L, Cornelius, Amber R, Gray-Gaillard, Sophie L, Karmacharya, Trishala, Tuen, Michael, Wilson, Jimmy P, Tasissa, Meron F, Goins, Shelby, Herati, Ramin Sedaghat, Mulligan, Mark J

“…Around the world, rollout of COVID-19 vaccines has been used as a strategy to end COVID-19-related restrictions and the pandemic. Several COVID-19 vaccine…”
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Improved retroviral vector design results in sustained expression after adult gene therapy in mucopolysaccharidosis I mice by Sedaghat Herati, Ramin, Ma, Xiucui, Tittiger, Mindy, Ohlemiller, Kevin K., Kovacs, Attila, Ponder, Katherine P.

“…Background Mucopolysaccharidosis I (MPS I) is a lysosomal storage disease due to α‐L‐iduronidase (IDUA) deficiency that results in the accumulation of…”
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What Is the Predictive Value of Animal Models for Vaccine Efficacy in Humans? Consideration of Strategies to Improve the Value of Animal Models by Herati, Ramin Sedaghat, Wherry, E John

“…Animal models are an essential feature of the vaccine design toolkit. Although animal models have been invaluable in delineating the mechanisms of immune…”
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Cutting Edge: IL-4, IL-21, and IFN-γ Interact To Govern T-bet and CD11c Expression in TLR-Activated B Cells by Naradikian, Martin S, Myles, Arpita, Beiting, Daniel P, Roberts, Kenneth J, Dawson, Lucas, Herati, Ramin Sedaghat, Bengsch, Bertram, Linderman, Susanne L, Stelekati, Erietta, Spolski, Rosanne, Wherry, E John, Hunter, Christopher, Hensley, Scott E, Leonard, Warren J, Cancro, Michael P

“…T-bet and CD11c expression in B cells is linked with IgG2c isotype switching, virus-specific immune responses, and humoral autoimmunity. However, the…”
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Deep immune profiling by mass cytometry links human T and NK cell differentiation and cytotoxic molecule expression patterns by Bengsch, Bertram, Ohtani, Takuya, Herati, Ramin Sedaghat, Bovenschen, Niels, Chang, Kyong-Mi, Wherry, E. John

“…The elimination of infected or tumor cells by direct lysis is a key T and NK cell effector function. T and NK cells can kill target cells by coordinated…”
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Circulating CXCR5+PD-1+ response predicts influenza vaccine antibody responses in young adults but not elderly adults by Herati, Ramin Sedaghat, Reuter, Morgan A, Dolfi, Douglas V, Mansfield, Kathleen D, Aung, Htin, Badwan, Osama Z, Kurupati, Raj K, Kannan, Senthil, Ertl, Hildegund, Schmader, Kenneth E, Betts, Michael R, Canaday, David H, Wherry, E John

“…Although influenza vaccination is recommended for all adults annually, the incidence of vaccine failure, defined as weak or absent increase in neutralizing Ab…”
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PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine by Herati, Ramin Sedaghat, Knorr, David A., Vella, Laura A., Silva, Luisa Victoria, Chilukuri, Lakshmi, Apostolidis, Sokratis A., Huang, Alexander C., Muselman, Alexander, Manne, Sasikanth, Kuthuru, Oliva, Staupe, Ryan P., Adamski, Sharon A., Kannan, Senthil, Kurupati, Raj K., Ertl, Hildegund C. J., Wong, Jeffrey L., Bournazos, Stylianos, McGettigan, Suzanne, Schuchter, Lynn M., Kotecha, Ritesh R., Funt, Samuel A., Voss, Martin H., Motzer, Robert J., Lee, Chung-Han, Bajorin, Dean F., Mitchell, Tara C., Ravetch, Jeffrey V., Wherry, E. John

“…Anti-programmed death-1 (anti-PD-1) immunotherapy reinvigorates CD8 T cell responses in patients with cancer but PD-1 is also expressed by other immune cells,…”
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Identification of flu-specific ICOS+CD38+ cTfh after influenza vaccination by Muselman, Alexander D, Herati, Ramin Sedaghat, Vella, Laura, Su, Laura, Tebas, Pablo, Wherry, E. John

“…Abstract The foundation of successful vaccines lies in the ability to prime the immune system to target a specific pathogen. The interaction between follicular…”
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SARS-CoV-2 inflammation durably imprints memory CD4 T cells by Gray-Gaillard, Sophie L, Solis, Sabrina M, Chen, Han M, Monteiro, Clarice, Ciabattoni, Grace, Samanovic, Marie I, Cornelius, Amber R, Williams, Tijaana, Geesey, Emilie, Rodriguez, Miguel, Ortigoza, Mila Brum, Ivanova, Ellie N, Koralov, Sergei B, Mulligan, Mark J, Herati, Ramin Sedaghat

“…Memory CD4 T cells are critical to human immunity, yet it is unclear whether viral inflammation during memory formation has long-term consequences. Here, we…”
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IL4, IL21, and IFNγ interact to govern TBET and CD11c expression in TLR-activated B cells1 by Naradikian, Martin S., Myles, Arpita, Beiting, Daniel P., Roberts, Kenneth J., Dawson, Lucas, Herati, Ramin Sedaghat, Bengsch, Bertram, Linderman, Susanne L., Stelekati, Erietta, Spolski, Rosanne, Wherry, E. John, Hunter, Christopher, Hensley, Scott E., Leonard, Warren J., Cancro, Michael P.

“…TBET and CD11c expression in B cells is linked with IgG 2c isotype switching, virus-specific immune responses, and humoral autoimmunity. However, the…”
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Synthesis of 1-methoxypoly(oxyethylene)benzocyclobutene and its diels-alder reactions by Herati, Reza Sedaghat, Herati, Ramin Sedaghat

“…A new poly(ethylene glycol) derivative, 1‐methoxypoly(oxyethylene)benzocyclobutene (1) was prepared from the reaction of 1‐benzocyclobutenyl 1‐hydroxyethyl…”
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Radiographic evaluation of bones and joints in mucopolysaccharidosis I and VII dogs after neonatal gene therapy by Herati, Ramin Sedaghat, Knox, Van W., O’Donnell, Patricia, D’Angelo, Marina, Haskins, Mark E., Ponder, Katherine P.

“…Mucopolysaccharidosis I (MPS I) and MPS VII are due to deficient activity of the glycosaminoglycan-degrading lysosomal enzymes α- l-iduronidase and…”
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