Search Results - "Herald, Delbert L."

Antineoplastic Agents. 556. Isolation and Structure of Coprinastatin 1 from Coprinus cinereus by Pettit, George R, Meng, Yanhui, Pettit, Robin K, Herald, Delbert L, Cichacz, Zbigniew A, Doubek, Dennis L, Richert, Linda

“…Cancer cell line bioassay-guided separation of an ethyl acetate extract prepared from a plant-associated fungus, Coprinus cinereus, led to the isolation of…”
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Antineoplastic Agents. 570. Isolation and Structure Elucidation of Bacillistatins 1 and 2 from a Marine Bacillus silvestris by Pettit, George R, Knight, John C, Herald, Delbert L, Pettit, Robin K, Hogan, Fiona, Mukku, Venugopal J. R. V, Hamblin, John S, Dodson, Michael J, Chapuis, Jean-Charles

“…Two new cyclodepsipeptides designated bacillistatins 1 (1) and 2 (2) have been isolated from cultures of a sample of Bacillus silvestris that was obtained from…”
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Antineoplastic Agents. 565. Synthesis of Combretastatin D-2 Phosphate and Dihydro-combretastatin D-2 by Pettit, George R, Quistorf, Peter D, Fry, Jeremy A, Herald, Delbert L, Hamel, Ernest, Chapuis, Jean-Charles

“…A modified synthetic route to combretastatin D-2 (5) was devised in order to further evaluate its biological activity, for its conversion to phosphate prodrugs…”
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Antineoplastic Agents. 590. X-ray Crystal Structure of Dolastatin 16 and Syntheses of the Dolamethylleuine and Dolaphenvaline Units by Pettit, George R, Smith, Thomas H, Xu, Jun-Ping, Herald, Delbert L, Flahive, Erik J, Anderson, Collin R, Belcher, Paul E, Knight, John C

“…Three advances necessary to bring dolastatin 16 (1) into full-scale preclinical development as an anticancer drug have been accomplished. The X-ray crystal…”
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Antineoplastic Agents. 558. Ampelocissus sp. Cancer Cell Growth Inhibitory Constituents by Pettit, George R, Mukku, Venugopal J. R. V, Cragg, Gordon, Herald, Delbert L, Knight, John C, Herald, Cherry L, Chapuis, Jean-Charles

“…An investigation of the Phillippine Ampelocissus sp. roots for cancer cell growth inhibitory components led to the isolation of a new acetogenin characterized…”
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Isolation of Labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens by Pettit, George R, Knight, John C, Herald, Delbert L, Davenport, Richard, Pettit, Robin K, Tucker, Bruce E, Schmidt, Jean M

“…Investigation of Pseudomonas syringae pv. coronafaciens cancer cell growth inhibitory constituents led to the isolation of 2-isobutyl-5-(3-indolyl)oxazole (1)…”
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Antineoplastic Agents. 443. Synthesis of the Cancer Cell Growth Inhibitor Hydroxyphenstatin and Its Sodium Diphosphate Prodrug by Pettit, George R, Grealish, Matthew P, Herald, Delbert L, Boyd, Michael R, Hamel, Ernest, Pettit, Robin K

“…A structure−activity relationship (SAR) study of the South African willow tree (Combretum caffrum) antineoplastic constituent combretastatin A-4 (3b) led to…”
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Studies directed towards the refinement of the pancratistatin cytotoxic pharmacophore by MCNULTY, James, MAO, Justin, GIBE, Romelo, MO, Ruowei, WOLF, Sonja, PETTIT, George R, HERALD, Delbert L, BOYD, Michael R

“…Two deoxy-analogues of the anticancer/antiviral agent pancratistatin containing functionality complementary to the minimum structural pharmacophore were…”
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Antineoplastic Agents 430. Isolation and Structure of Cribrostatins 3, 4, and 5 from the Republic of Maldives Cribrochalina Species by Pettit, George R, Knight, John C, Collins, Jeremiah C, Herald, Delbert L, Pettit, Robin K, Boyd, Michael R, Young, Victor G

“…Continued investigation of cancer-cell growth-inhibitory constituents of the blue marine sponge Cribrochalina sp. has led to discovery of cribrostatins 3 (4a),…”
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Antineoplastic Agents. 499. Synthesis of Hystatin 2 and Related 1H-Benzo[de][1,6]-naphthyridinium Salts from Aaptamine by Pettit, George R, Hoffmann, Holger, Herald, Delbert L, Blumberg, Peter M, Hamel, Ernest, Schmidt, Jean M, Chang, Yung, Pettit, Robin K, Lewin, Nancy E, Pearce, Larry V

“…The marine sponge constituent aaptamine (1) has been converted to the cancer cell growth inhibitor and antibiotic designated hystatin 2 (8a). Herein, we also…”
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Antineoplastic Agents. 550. Synthesis of 10b(S)-Epipancratistatin from (+)-Narciclasine ⊥ ,1 by Pettit, George R, Melody, Noeleen, Herald, Delbert L, Knight, John C, Chapuis, Jean-Charles

“…By means of a five-step reaction sequence, narciclasine (2a), isolated from Narcissus sp., was converted to 10b(S)-epipancratistatin (3a) in 5.7% overall…”
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Antineoplastic Agents. 445. Synthesis and Evaluation of Structural Modifications of (Z)- and (E)-Combretastatin A-4 by Pettit, George R, Rhodes, Monte R, Herald, Delbert L, Hamel, Ernest, Schmidt, Jean M, Pettit, Robin K

“…A series of cis- and trans-stilbenes related to combretastatin A-4 (1a), with a variety of substituents at the 3‘-position of the aryl B-ring, were synthesized…”
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The Cephalostatins. 23. Conversion of Hecogenin to a Steroidal 1,6-Dioxaspiro[5.5]nonane Analogue for Cephalostatin 1 by Pettit, George R, Moser, Bryan R, Herald, Delbert L, Knight, John C, Chapuis, Jean-Charles, Zheng, Xing

“…Cephalostatin 1 (1) has proved to be a remarkably potent cancer cell growth inhibitor. Since this steroidal alkaloid constituent of the marine worm…”
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Isolation and Structure of Cancer Cell Growth Inhibitory Tetracyclic Triterpenoids from the Zimbabwean Monadenium lugardae by Pettit, George R, Ye, Qinghua, Herald, Delbert L, Knight, John C, Hogan, Fiona, Melody, Noeleen, Mukku, Venugopal J. R. V, Doubek, Dennis L, Chapuis, Jean-Charles

“…The Zimbabwean medicinal plant Monadenium lugardae was evaluated as a potential source of new anticancer constituents. Four new tetracyclic triterpene (1–4)…”
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The Cephalostatins. 23. Conversion of Hecogenin to a Steroidal 1,6-Dioxaspiro[5.5]nonane Analogue for Cephalostatin 11 by Pettit, George R, Moser, Bryan R, Herald, Delbert L, Knight, John C, Chapuis, Jean-Charles, Zheng, Xing

“…Cephalostatin 1 (1) has proved to be a remarkably potent cancer cell growth inhibitor. Since this steroidal alkaloid constituent of the marine worm…”
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Antineoplastic Agents. 362. Isolation and X-ray Crystal Structure of Dibromophakellstatin from the Indian Ocean Sponge Phakellia mauritiana by Pettit, George R, McNulty, James, Herald, Delbert L, Doubek, Dennis L, Chapuis, Jean-Charles, Schmidt, Jean M, Tackett, Larry P, Boyd, Michael R

“…Bioassay-guided isolation procedures using human tumor cell lines led to isolation of dibromophakellstatin (4) from the Republic of Seychelles sponge Phakellia…”
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Synthesis of 10b(R)-Hydroxypancratistatin, 10b(S)-Hydroxy-1-epipancratistatin, 10b(S)-Hydroxy-1,2-diepipancratistatin and Related Isocarbostyrils by R. Pettit, George, Melody, Noeleen, L. Herald, Delbert, M. Schmidt, Jean, K. Pettit, Robin, Chapuis, Jean-Charles

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Antineoplastic Agents. 450. Synthesis of (+)-Pancratistatin from (+)-Narciclasine as Relay1a by Pettit, George R, Melody, Noeleen, Herald, Delbert L

“…(+)-Narciclasine (2) available in quantity from certain Amaryllidaceae species or by total synthesis was employed as a precursor for a 10-step synthetic…”
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Antineoplastic agents 582. Part 1: Isolation and structure of a cyclobutane-type sesquiterpene cancer cell growth inhibitor from Coprinus cinereus (Coprinaceae) by Pettit, George R., Meng, Yanhui, Pettit, Robin K., Herald, Delbert L., Hogan, Fiona, Cichacz, Zbigniew A.

“…Three new sesquiterpenes were isolated from the multicellular basidiomycete Coprinus cinereus. Bioassay-guided (murine P388 lymphocytic leukemia and human…”
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Isolation and Structures of Schleicherastatins 1−7 and Schleicheols 1 and 2 from the Teak Forest Medicinal Tree Schleichera oleosa by Pettit, George R, Numata, Atsushi, Cragg, Gordon M, Herald, Delbert L, Takada, Tamie, Iwamoto, Chika, Riesen, Roland, Schmidt, Jean M, Doubek, Dennis L, Goswami, Animesh

“…Bioassay (P-388 lymphocytic leukemia cell line)-guided separation of an extract prepared from the bark and stem of the Sri Lankan tree Schleichera oleosa led…”
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