Search Results - "Heppner, FL"

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration by Lehmann, Sabrina M, Krüger, Christina, Park, Boyoun, Derkow, Katja, Rosenberger, Karen, Baumgart, Jan, Trimbuch, Thorsten, Eom, Gina, Hinz, Michael, Kaul, David, Habbel, Piet, Kälin, Roland, Franzoni, Eleonora, Rybak, Agnieszka, Nguyen, Duong, Veh, Rüdiger, Ninnemann, Olaf, Peters, Oliver, Nitsch, Robert, Heppner, Frank L, Golenbock, Douglas, Schott, Eckart, Ploegh, Hidde L, Wulczyn, F Gregory, Lehnardt, Seija

“…In addition to their function in gene regulation, certain microRNAs can be secreted by cells. Here, the authors show that the microRNA let-7 can cause…”
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Immune-Mediated Necrotizing Myopathy Is Characterized by a Specific Th1-M1 Polarized Immune Profile by Preuße, Corinna, Goebel, Hans H, Held, Josephin, Wengert, Oliver, Scheibe, Franziska, Irlbacher, Kerstin, Koch, Arend, Heppner, Frank L, Stenzel, Werner

“…Immune-mediated necrotizing myopathy (IMNM) is considered one of the idiopathic inflammatory myopathies, comprising dermatomyositis, polymyositis, and…”
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Experimental autoimmune encephalomyelitis repressed by microglial paralysis by Aguzzi, Adriano, Heppner, Frank L, Greter, Melanie, Marino, Denis, Falsig, Jeppe, Raivich, Gennadij, Hövelmeyer, Nadine, Waisman, Ari, Rülicke, Thomas, Prinz, Marco, Priller, Josef, Becher, Burkhard

“…Although microglial activation occurs in inflammatory, degenerative and neoplastic central nervous system (CNS) disorders, its role in pathogenesis is unclear…”
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Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis by Becher, Burkhard, Greter, Melanie, Heppner, Frank L, Lemos, Maria P, Odermatt, Bernhard M, Goebels, Norbert, Laufer, Terri, Noelle, Randolph J

“…Immunization with myelin antigens leads to the development of experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. The disease can…”
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A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration by Buch, Thorsten, Waisman, Ari, Heppner, Frank L, Tertilt, Christine, Heinen, Tobias J A J, Kremer, Marcel, Wunderlich, F Thomas, Jung, Steffen

“…A new system for lineage ablation is based on transgenic expression of a diphtheria toxin receptor (DTR) in mouse cells and application of diphtheria toxin…”
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ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19 by Pietzner, Maik, Chua, Robert Lorenz, Wheeler, Eleanor, Jechow, Katharina, Willett, Julian D. S., Radbruch, Helena, Trump, Saskia, Heidecker, Bettina, Zeberg, Hugo, Heppner, Frank L., Eils, Roland, Mall, Marcus A., Richards, J. Brent, Sander, Leif-Erik, Lehmann, Irina, Lukassen, Sören, Wareham, Nicholas J., Conrad, Christian, Langenberg, Claudia

“…Despite two years of intense global research activity, host genetic factors that predispose to a poorer prognosis of COVID-19 infection remain poorly…”
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Sympathetic Innervation of Lymphoreticular Organs Is Rate Limiting for Prion Neuroinvasion by Glatzel, Markus, Heppner, Frank L., Albers, Kathryn M., Aguzzi, Adriano

“…Transmissible spongiform encephalopathies are commonly propagated by extracerebral inoculation of the infectious agent. Indirect evidence suggests that entry…”
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Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion by Aguzzi, Adriano, Prinz, Marco, Heikenwalder, Mathias, Junt, Tobias, Schwarz, Petra, Glatzel, Markus, Heppner, Frank L, Fu, Yang-Xin, Lipp, Martin

“…Peripheral infection is the natural route of transmission in most prion diseases. Peripheral prion infection is followed by rapid prion replication in lymphoid…”
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The most fulminant course of the Marburg variant of multiple sclerosis—autopsy findings by Nunes, JC, Radbruch, H, Walz, R, Lin, K, Stenzel, W, Prokop, S, Koch, A, Heppner, FL

“…Multiple sclerosis (MS) is usually a chronic and disabling inflammatory disease. Marburg’s type of MS is characterized by rapid progression and severe disease…”
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Prevention of Scrapie Pathogenesis by Transgenic Expression of Anti-Prion Protein Antibodies by Heppner, Frank L., Musahl, Christine, Arrighi, Isabelle, Klein, Michael A., Rülicke, Thomas, Oesch, Bruno, Zinkernagel, Rolf M., Kalinke, Ulrich, Aguzzi, Adriano

“…Variant Creutzfeldt-Jakob disease and bovine spongiform encephalopathy are initiated by extracerebral exposure to prions. Although prion transmission from…”
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Transepithelial prion transport by M cells by Heppner, Frank L, Christ, Andreas D, Klein, Michael A, Prinz, Marco, Fried, Michael, Kraehenbuhl, Jean-Pierre, Aguzzi, Adriano

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No superoxide dismutase activity of cellular prion protein in vivo by Hutter, Gregor, Heppner, Frank L, Aguzzi, Adriano

“…Prion diseases are characterized by the deposition of PrP(Sc), an abnormal form of the cellular prion protein PrP(C), which is encoded by the Prnp gene. PrP(C)…”
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Absence of the prion protein homologue Doppel causes male sterility by Behrens, Axel, Genoud, Nicolas, Naumann, Heike, Rülicke, Thomas, Janett, Fredi, Heppner, Frank L., Ledermann, Birgit, Aguzzi, Adriano

“…The agent that causes prion diseases is thought to be identical with PrPSc, a conformer of the normal prion protein PrPC. PrPC‐deficient mice do not exhibit…”
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Paracrine Inhibition of Prion Propagation by Anti-PrP Single-Chain Fv Miniantibodies by DONOFRIO, Gaetano, HEPPNER, Frank L, POLYMENIDOU, Magdalini, MUSAHL, Christine, AGUZZI, Adriano

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Oral Prion Infection Requires Normal Numbers of Peyer's Patches but Not of Enteric Lymphocytes by Prinz, Marco, Huber, Gerhard, Macpherson, Andrew J.S., Heppner, Frank L., Glatzel, Markus, Eugster, Hans-Pietro, Wagner, Norbert, Aguzzi, Adriano

“…Prion pathogenesis following oral exposure is thought to involve gut-associated lymphatic tissue, which includes Peyer's patches (PPs) and M cells. Recruitment…”
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Humoral Immune Response to Native Eukaryotic Prion Protein Correlates with Anti-Prion Protection by Polymenidou, Magdalini, Heppner, Frank L., Pellicioli, Erica C., Urich, Eduard, Miele, Gino, Braun, Nathalie, Wopfner, Franziska, Schätzl, Hermann M., Becher, Burkhard, Aguzzi, Adriano

“…Prion diseases are characterized by the deposition of an abnormal form (termed PrP Sc) of the cellular prion protein ( PrP C). Because antibodies to PrP C can…”
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Circumventing Tolerance to the Prion Protein (PrP): Vaccination with PrP-Displaying Retrovirus Particles Induces Humoral Immune Responses against the Native Form of Cellular PrP by NIKLES, Daphne, BACH, Patricia, BOLLER, Klaus, MERTEN, Christoph A, MONTRASIO, Fabio, HEPPNER, Frank L, AGUZZI, Adriano, CICHUTEK, Klaus, KALINKE, Ulrich, BUCHHOLZ, Christian J

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Recent developments in prion immunotherapy by Heppner, Frank L, Aguzzi, Adriano

“…Antibody-based immunotherapy may represent a realistic approach against prion diseases, given that antibodies to the cellular prion protein PrP C have been…”
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Interventional strategies against prion diseases by Aguzzi, Adriano, Glatzel, Markus, Montrasio, Fabio, Prinz, Marco, Heppner, Frank L

“…Only a few years ago, the idea that transmissible spongiform encephalopathies could be treated pharmacologically would have met with considerable scepticism…”
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Detection of kappa and delta opioid receptors in skin—Outside the nervous system by Salemi, Souzan, Aeschlimann, André, Reisch, Nataša, Jüngel, Astrid, Gay, Renate E., Heppner, Frank L., Michel, Beat A., Gay, Steffen, Sprott, Haiko

“…Opioid receptors (OR) are widely expressed in the central nervous system (CNS). Opioid antinociception might be initiated by activation of OR outside the CNS,…”
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