Search Results - "Heppner, D G"

Preclinical Evaluation of the Safety and Immunogenicity of a Vaccine Consisting of Plasmodium falciparum Liver-Stage Antigen 1 with Adjuvant AS01B Administered Alone or Concurrently with the RTS,S/AS01B Vaccine in Rhesus Primates by Pichyangkul, S, Kum-Arb, U, Yongvanitchit, K, Limsalakpetch, A, Gettayacamin, M, Lanar, D.E, Ware, L.A, Stewart, V.A, Heppner, D.G, Mettens, P, Cohen, J.D, Ballou, W.R, Fukuda, M.M

“…Several lines of evidence suggest that targeting pre-erythrocytic-stage parasites for malaria vaccine development can provide sterile immunity. The objectives…”
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Safety and immunogenicity of the RTS,S/AS02A candidate malaria vaccine in children aged 1–4 in Mozambique by Macete, E., Aponte, J. J., Guinovart, C., Sacarlal, J., Ofori‐Anyinam, O., Mandomando, I., Espasa, M., Bevilacqua, C., Leach, A., Dubois, M. C., Heppner, D. G., Tello, L., Milman, J., Cohen, J., Dubovsky, F., Tornieporth, N., Thompson, R., Alonso, P. L.

“…Summary Background  The development of a malaria vaccine remains a public health priority for sub‐Saharan Africa. RTS,S/AS02A candidate malaria vaccine has…”
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Safety, Immunogenicity, and Efficacy of a Recombinantly Produced Plasmodium falciparum Circumsporozoite Protein-Hepatitis B Surface Antigen Subunit Vaccine by Gordon, D. M., McGovern, T. W., Krzych, U., Cohen, J. C., Schneider, I., LaChance, R., Heppner, D. G., Yuan, G., Hollingdale, M., Slaoui, M., Hauser, P., Voet, P., Sadoff, J. C., Ballou, W. R.

“…Twenty malaria-naive volunteers received a recombinant Plasmodium falciparum malaria vaccine (RTS,S) containing 19 NANP repeats and the carboxy terminus (amino…”
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A phase IIa, randomized, double-blind, safety, immunogenicity and efficacy trial of Plasmodium falciparum vaccine antigens merozoite surface protein 1 and RTS,S formulated with AS02 adjuvant in healthy, malaria-naïve adults by Cummings, J.F., Polhemus, M.E., Kester, K.E., Ockenhouse, C.F., Gasser, R.A., Coyne, P., Wortmann, G., Nielsen, R.K., Schaecher, K., Holland, C.A., Krzych, U., Tornieporth, N., Soisson, L.A., Angov, E., Heppner, D.G.

“…To improve the efficacy of Plasmodium falciparum malaria vaccine RTS,S/AS02, we conducted a study in 2001 in healthy, malaria-naïve adults administered…”
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Plasmodium falciparum antimalarial drug susceptibility on the north-western border of Thailand during five years of extensive use of artesunate-mefloquine by Brockman, A., Price, R.N., van Vugt, M., Heppner, D.G., Walsh, D., Sookto, P., Wimonwattrawatee, T., Looareesuwan, S., White, N.J., Nosten, F.

“…Following a marked decline in the efficacy in vivo of mefloquine between 1990 and 1994, a combination of artesunate (4 mg/kg/d for 3 d) and mefloquine (25…”
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Randomized Dose-Ranging Study of the Safety and Efficacy of WR 238605 (Tafenoquine) in the Prevention of Relapse of Plasmodium vivax Malaria in Thailand by Walsh, Douglas S., Looareesuwan, Sornchai, Wilairatana, Polrat, Heppner, D. Gray, Tang, Douglas B., Brewer, Thomas G., Chokejindachai, Watcharee, Viriyavejakul, Parnpen, Kyle, Dennis E., Milhous, Wilbur K., Schuster, Brian G., Horton, John, Braitman, David J., Brueckner, Ralf P.

“…WR 238605 is an 8-aminoquinoline developed for the radical cure of Plasmodium vivax. Forty-four P. vivax-infected patients were randomly assigned to 1 of 4…”
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CpG oligodeoxynucleotide enhances immunity against blood-stage malaria infection in mice parenterally immunized with a yeast-expressed 19 kDa carboxyl-terminal fragment of Plasmodium yoelii merozoite surface protein-1 (MSP1 19) formulated in oil-based Montanides by Hirunpetcharat, C., Wipasa, J., Sakkhachornphop, S., Nitkumhan, T., Zheng, Y.Z., Pichyangkul, S., Krieg, A.M., Walsh, D.S., Heppner, D.G., Good, M.F.

“…The 19 kDa carboxyl-terminal fragment of Plasmodium yoelii merozoite surface protein-1 (MSP1 19), an analog of the leading falciparum malaria vaccine…”
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Randomized Trial of 3-Dose Regimens of Tafenoquine (WR238605) versus Low-Dose Primaquine for Preventing Plasmodium vivax Malaria Relapse by Walsh, Douglas S., Wilairatana, Polrat, Tang, Douglas B., Heppner, D. Gray, Brewer, Thomas G., Krudsood, Srivicha, Silachamroon, Udomsak, Phumratanaprapin, Weerapong, Siriyanonda, Duangsuda, Looareesuwan, Sornchai

“…Background. Tafenoquine is an 8-aminoquinoline developed as a more effective replacement for primaquine. In a previous dose-ranging study in Thailand, 3…”
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Safety, Immunogenicity, and Efficacy of Plasmodium falciparum Repeatless Circumsporozoite Protein Vaccine Encapsulated in Liposomes by Heppner, D. G., Gordon, D. M., Gross, M., Wellde, B., Leitner, W., Krzych, U., Schneider, I., Wirtz, R. A., Richards, R. L., Trofa, A., Hall, T., Sadoff, J. C., Boerger, P., Alving, C. R., Sylvester, D. R., Porter, T. G., Ballou, W. R.

“…Seventeen malaria-naive volunteers received a recombinant Plasmodium falciparum vaccine (RLF) containing the carboxy- and the amino-terminal of the…”
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In vitro sensitivity of Plasmodium falciparum to artesunate in Thailand by WONGSRICHANALAI, C, WIMONWATTRAWATEE, T, SOOKTO, P, LAOBOONCHAI, A, HEPPNER, D. G, KYLE, D. E, WERNSDORFER, W. H

“…Reported are the in vitro susceptibilities of Plasmodium falciparum to artesunate, mefloquine, quinine and chloroquine of 86 isolates and to dihydroartemisinin…”
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Comparison of a rapid field immunochromatographic test to expert microscopy for the detection of Plasmodium falciparum asexual parasitemia in Thailand by Wongsrichanalai, C, Chuanak, N, Tulyayon, S, Thanoosingha, N, Laoboonchai, A, Thimasarn, K, Brewer, T.G, Heppner, D.G

“…We assessed a rapid, Plasmodium falciparum histidine rich protein 2 (PfHRP2)-based immunochromatographic test (ICT Malaria Pf Test™), for detection of asexual…”
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Salmonella typhi Vaccine Strain CVD 908 Expressing the Circumsporozoite Protein of Plasmodium falciparum: Strain Construction and Safety and Immunogenicity in Humans by Gonzalez, Cesar, Hone, David, Noriega, Fernando R., Tacket, Carol O., Davis, Jonathan R., Losonsky, Genevieve, Nataro, James P., Hoffman, Stephen, Malik, Anita, Nardin, Elizabeth, Sztein, Marcelo B., Heppner, D. Gray, Fouts, Timothy R., Isibasi, Armando, Levine, Myron M.

“…resp, encoding amino acids 21-398 of Plasmodium falciparum circumsporozoite protein (CSP), under control of tacP was integrated into the chromosomal ΔaroC…”
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Comparative clinical trial of artesunate suppositories and oral artesunate in combination with mefloquine in the treatment of children with acute falciparum malaria by Sabchareon, A, Attanath, P, Chanthavanich, P, Phanuaksook, P, Prarinyanupharb, V, Poonpanich, Y, Mookmanee, D, Teja-Isavadharm, P, Heppner, D G, Brewer, T G, Chongsuphajaisiddhi, T

“…A randomized pilot study to compare the safety and efficacy of artesunate suppositories (15 mg/kg/day for three days) versus oral artesunate (6 mg/kg/day for…”
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Malaria Blood Stage Parasites Activate Human Plasmacytoid Dendritic Cells and Murine Dendritic Cells through a Toll-Like Receptor 9-Dependent Pathway by Pichyangkul, Sathit, Yongvanitchit, Kosol, Kum-arb, Utaiwan, Hemmi, Hiroaki, Akira, Shizuo, Krieg, Arthur M, Heppner, D. Gray, Stewart, V. Ann, Hasegawa, Hitoshi, Looareesuwan, Sornchai, Shanks, G. Dennis, Miller, R. Scott

“…A common feature of severe Plasmodium falciparum infection is the increased systemic release of proinflammatory cytokines that contributes to the pathogenesis…”
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Pharmacokinetics of Mefloquine Combined with Artesunate in Children with Acute Falciparum Malaria by PRICE, R, SIMPSON, J. A, TEJA-ISAVATHARM, P, MYINT MYINT THAN, LUXEMBURGER, C, HEPPNER, D. G, TAN CHONGSUPHAJAISIDDHI, NOSTEN, F, WHITE, N. J

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Evaluation of the safety and immunogenicity of Plasmodium falciparum apical membrane antigen 1, merozoite surface protein 1 or RTS,S vaccines with adjuvant system AS02A administered alone or concurrently in rhesus monkeys by Pichyangkul, S, Tongtawe, P, Kum-Arb, U, Yongvanitchit, K, Gettayacamin, M, Hollingdale, M.R, Limsalakpetch, A, Stewart, V.A, Lanar, D.E, Dutta, S, Angov, E, Ware, L.A, Bergmann-Leitner, E.S, House, B, Voss, G, Dubois, M.C, Cohen, J.D, Fukuda, M.M, Heppner, D.G, Miller, R.S

“…Abstract In an effort to broaden the immune response induced by the RTS,S/AS02A ,vaccine, we have evaluated the immunogenicity of the RTS,S antigen when…”
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Safety and immunogenicity of single-dose live oral cholera vaccine CVD 103-HgR in 5-9-year-old Indonesian children by Suharyono, Simanjuntak, C, Witham, N, Punjabi, N, Heppner, D G, Losonsky, G, Totosudirjo, H, Rifai, A R, Clemens, J, Lim, Y L

“…Oral vaccines offer great promise as public-health measures to prevent disease in less-developed countries. CVD 103-HgR, a genetically engineered, attenuated,…”
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Azithromycin prophylaxis against a chloroquine-resistant strain of Plasmodium falciparum by Kuschner, R A, Heppner, D G, Andersen, S L, Wellde, B T, Hall, T, Schneider, I, Ballou, W R, Foulds, G, Sadoff, J C, Schuster, B

“…Azithromycin has antimalarial activity and favourable pharmacokinetic properties for a prophylactic antimalarial agent. We investigated the ability of…”
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Regulation of leukocyte adhesion molecules CD11b/CD18 and leukocyte adhesion molecule-1 on phagocytic cells activated by malaria pigment by Pichyangkul, S, Saengkrai, P, Yongvanitchit, K, Heppner, D G, Kyle, D E, Webster, H K

“…There is increasing evidence that inappropriate immune activation induced by parasite products occurs in malaria disease. To further elucidate the role of…”
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Human ehrlichiosis in Thailand by Heppner, D G, Wongsrichanalai, C, Walsh, D S, McDaniel, P, Eamsila, C, Hanson, B, Paxton, H

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