Search Results - "Heppler, Lisa N."

Targeting Oncogenic Transcription Factors: Therapeutic Implications of Endogenous STAT Inhibitors by Heppler, Lisa N, Frank, David A

“…Misregulation of transcription factors, including signal transducer and activator of transcription (STAT) proteins, leads to inappropriate gene expression…”
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Gene expression–based discovery of atovaquone as a STAT3 inhibitor and anticancer agent by Xiang, Michael, Kim, Haesook, Ho, Vincent T., Walker, Sarah R., Bar-Natan, Michal, Anahtar, Melodi, Liu, Suhu, Toniolo, Patricia A., Kroll, Yasmin, Jones, Nichole, Giaccone, Zachary T., Heppler, Lisa N., Ye, Darwin Q., Marineau, Jason J., Shaw, Daniel, Bradner, James E., Blonquist, Traci, Neuberg, Donna, Hetz, Claudio, Stone, Richard M., Soiffer, Robert J., Frank, David A.

“…The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is frequently activated inappropriately in a wide range of…”
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Atovaquone is active against AML by upregulating the integrated stress pathway and suppressing oxidative phosphorylation by Stevens, Alexandra M., Xiang, Michael, Heppler, Lisa N., Tošić, Isidora, Jiang, Kevin, Munoz, Jaime O., Gaikwad, Amos S., Horton, Terzah M., Long, Xin, Narayanan, Padmini, Seashore, Elizabeth L., Terrell, Maci C., Rashid, Raushan, Krueger, Michael J., Mangubat-Medina, Alicia E., Ball, Zachary T., Sumazin, Pavel, Walker, Sarah R., Hamada, Yoshimasa, Oyadomari, Seiichi, Redell, Michele S., Frank, David A.

“…Atovaquone, a US Food and Drug Administration–approved antiparasitic drug previously shown to reduce interleukin-6/STAT3 signaling in myeloma cells, is well…”
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Inhibit versus Destroy: Are PROTAC Degraders the Solution to Targeting STAT3? by Heppler, Lisa N., Frank, David A.

“…Despite the role of STAT3 as a known driver of oncogenesis, efforts to develop therapeutic STAT3 inhibitors have thus far been unsuccessful. In this issue of…”
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Rare mutations provide unique insight into oncogenic potential of STAT transcription factors by Heppler, Lisa N, Frank, David A

“…The inappropriate activation of transcription factors, including STATs, is known to promote tumor initiation and progression. The most common mechanisms of…”
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The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase by Heppler, Lisa N., Attarha, Sanaz, Persaud, Rosanne, Brown, Jennifer I., Wang, Peng, Petrova, Boryana, Tošić, Isidora, Burton, Foster B., Flamand, Yael, Walker, Sarah R., Yeh, Jennifer E., Zubarev, Roman A., Gaetani, Massimiliano, Kanarek, Naama, Page, Brent D.G., Frank, David A.

“…Cancer is often characterized by aberrant gene expression patterns caused by the inappropriate activation of transcription factors. Signal transducer and…”
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Targeting constitutively active STAT3 in chronic lymphocytic leukemia: A clinical trial of the STAT3 inhibitor pyrimethamine with pharmacodynamic analyses by Brown, Jennifer R., Walker, Sarah R., Heppler, Lisa N., Tyekucheva, Svitlana, Nelson, Erik A., Klitgaard, Josephine, Nicolais, Maria, Kroll, Yasmin, Xiang, Michael, Yeh, Jennifer E., Chaudhury, Mousumi, Giaccone, Zachary T., Fernandes, Stacey M., Jacobsen, Eric D., Fisher, David C., Freedman, Arnold S., Davids, Matthew S., Supko, Jeffrey G., Wu, Catherine, Frank, David A.

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Lipidome-based Targeting of STAT3-driven Breast Cancer Cells Using Poly-l-glutamic Acid-coated Layer-by-Layer Nanoparticles by Tošić, Isidora, Heppler, Lisa N, Egusquiaguirre, Susana P, Boehnke, Natalie, Correa, Santiago, Costa, Daniel F, Moore, Elizabeth A Grossman, Pal, Sharmistha, Richardson, Douglas S, Ivanov, Alexander R, Haas-Kogan, Daphne A, Nomura, Daniel K, Hammond, Paula T, Frank, David A

“…The oncogenic transcription factor STAT3 is aberrantly activated in 70% of breast cancers, including nearly all triple-negative breast cancers (TNBCs). Because…”
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Histone Deacetylase 6 (HDAC6) Promotes the Pro-survival Activity of 14-3-3ζ via Deacetylation of Lysines within the 14-3-3ζ Binding Pocket by Mortenson, Jeffrey B., Heppler, Lisa N., Banks, Courtney J., Weerasekara, Vajira K., Whited, Matthew D., Piccolo, Stephen R., Johnson, William E., Thompson, J. Will, Andersen, Joshua L.

“…The phospho-binding protein 14-3-3ζ acts as a signaling hub controlling a network of interacting partners and oncogenic pathways. We show here that lysines…”
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Rare mutations provide unique insight into oncogenic potential of STAT transcription factors by Heppler, Lisa N, Frank, David A

“…The inappropriate activation of transcription factors, including STATs, is known to promote tumor initiation and progression. The most common mechanisms of…”
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Abstract 387: Pyrimethamine inhibits STAT3 transcriptional activity via dihydrofolate reductase by Heppler, Lisa N., Walker, Sarah R., Attarha, Sanaz, Page, Brent D., Frank, David A.

“…Abstract Cancer is often characterized by aberrant gene expression patterns that alter cellular function. Such alterations are commonly caused by the…”
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Abstract 6418: Targeting STAT3-driven breast cancer cells using layer-by-layer nanoparticles by Tošić, Isidora, Heppler, Lisa N., Egusquiaguirre, Susana P., Boehnke, Natalie, Correa, Santiago, Costa, Daniel, Haas-Kogan, Daphne A., Hammond, Paula T., Frank, David A.

“…Abstract Inappropriate activation of the oncogenic transcription factor STAT3 is a common finding in breast cancer, in which it is constitutively activated in…”
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A Clinical Trial of the STAT3 Inhibitor Pyrimethamine in Chronic Lymphocytic Leukemia by Brown, Jennifer R., Walker, Sarah R., Heppler, Lisa N., Tyekucheva, Svitlana, Nelson, Erik, Klitgaard, Josephine L., Nicolais, Maria, Kroll, Yasmin, Xiang, Michael, Yeh, Jennifer E., Chaudhury, Mousumi, Giaccone, Zachary T., Fernandes, Stacey, Supko, Jeffrey G., Wu, Catherine J., Frank, David A.

“…Despite advances in targeted therapy, chronic lymphocytic leukemia (CLL) remains a highly prevalent and essentially incurable malignancy. One molecular…”
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