Search Results - "Hepkema, Bouke G."

Killer Cell Immunoglobulin-Like Receptor Haplotype B Modulates Susceptibility to EBV-Associated Classic Hodgkin Lymphoma by Jiang, Peijia, Nolte, Ilja M, Hepkema, Bouke G, Stulp, Marijke, van den Berg, Anke, Diepstra, Arjan

“…Tumor cells of classic Hodgkin lymphoma (cHL) are derived from antigen presenting B cells that are infected by Epstein Barr virus (EBV) in ~30% of patients…”
Get full text

Antigen and Cell-Based Assays for the Detection of Non-HLA Antibodies by Lammerts, Rosa G M, Altulea, Dania, Hepkema, Bouke G, Sanders, Jan-Stephan, van den Born, Jacob, Berger, Stefan P

“…To date, human leukocyte antigens (HLA) have been the major focus in the approach to acute and chronic antibody-mediated rejection (AMBR) in solid-organ…”
Get full text

Memory B-cell derived donor-specific antibodies do not predict outcome in sensitized kidney transplant recipients: a retrospective single-center study by Altulea, Dania, van den Born, Joost C, Diepstra, Arjan, Bungener, Laura, Terpstra, Dagmar, Hepkema, Bouke G, Lammerts, Rosa, Heeringa, Peter, Heidt, Sebastiaan, Otten, Henny, Reteig, Leon, Karahan, Gonca E, Berger, Stefan P, Sanders, Jan-Stephan

“…Repeated exposure to sensitizing events can activate HLA-specific memory B cells, leading to the production of donor-specific memory B cell antibodies (DSAm)…”
Get full text

Renal Endothelial Cytotoxicity Assay to Diagnose and Monitor Renal Transplant Recipients for Anti-Endothelial Antibodies by Lammerts, Rosa G. M., Born, Jacob van den, Huberts-Kregel, Magdalena, Gomes-Neto, Antonio W., Daha, Mohammed R., Hepkema, Bouke G., Sanders, Jan-Stephan, Pol, Robert A., Diepstra, Arjan, Berger, Stefan P.

“…Tissue-specific nonhuman leukocyte antigen (HLA) antigens can play crucial roles in allograft immunity and have been shown to trigger humoral responses leading…”
Get full text

Weak Expression of Terminal Complement in Active Antibody-Mediated Rejection of the Kidney by Tiller, Gesa, Lammerts, Rosa G M, Karijosemito, Jessy J, Alkaff, Firas F, Diepstra, Arjan, Pol, Robert A, Meter-Arkema, Anita H, Seelen, Marc A, van den Heuvel, Marius C, Hepkema, Bouke G, Daha, Mohamed R, van den Born, Jacob, Berger, Stefan P

“…The role of the complement system in antibody-mediated rejection (ABMR) is insufficiently understood. We aimed to investigate the role of local and systemic…”
Get full text

HLA expression and HLA type associations in relation to EBV status in Hispanic Hodgkin lymphoma patients by Fletcher, Luke B, Veenstra, Rianne N, Loo, Eric Y, Hwang, Amie E, Siddiqi, Imran N, Visser, Lydia, Hepkema, Bouke G, Nolte, Ilja M, van den Berg, Anke, Cozen, Wendy, Diepstra, Arjan

“…A proportion of classical Hodgkin lymphomas harbor the Epstein Barr virus (EBV). We previously demonstrated that associations between Human Leukocyte Antigen…”
Get full text

The increase of the global donor inventory is of limited benefit to patients of non-Northwestern European descent by van Walraven, Suzanna M, Brand, Anneke, Bakker, Jack N A, Heemskerk, Martin B A, Nillesen, Suzan, Bierings, Marc B, Bungener, Laura B, Hepkema, Bouke G, Lankester, Arjan, van der Meer, Arnold, Sintnicolaas, Kees, Somers, Judith A E, Spierings, Eric, Tilanus, Marcel G J, Voorter, Christien E M, Cornelissen, Jan J, Oudshoorn, Machteld

“…Between 2001 and 2012, the number of unrelated donors registered worldwide increased from 7 to 21 million, and the number of public cord blood units increased…”
Get full text

The prevalence of antibodies against the HLA-DRB3 protein in kidney transplantation and the correlation with HLA expression by Habets, Thomas H P M, Hepkema, Bouke G, Kouprie, Niels, Schnijderberg, Melanie C A, van Smaalen, Tim C, Bungener, Laura B, Christiaans, Maarten H L, Bos, Gerard M J, Vanderlocht, Joris

“…Human leukocyte antigen (HLA)-DRB3 is a functional HLA class II gene, which has a limited allele diversity in the human population. Furthermore, the HLA-DRB3…”
Get full text

Lectin complement pathway gene profile of donor and recipient determine the risk of bacterial infections after orthotopic liver transplantation by de Rooij, Bert‐Jan F., van Hoek, Bart, ten Hove, W. Rogier, Roos, Anja, Bouwman, Lee H., Schaapherder, Alexander F., Porte, Robert J., Daha, Mohamed R., van der Reijden, Johan J., Coenraad, Minneke J., Ringers, Jan, Baranski, Andrzej G., Hepkema, Bouke G., Hommes, Daniel W., Verspaget, Hein W.

“…Infectious complications after orthotopic liver transplantation (OLT) are a major clinical problem. The lectin pathway of complement activation is…”
Get full text

Toll-Like Receptor Family Polymorphisms Are Associated with Primary Renal Diseases but Not with Renal Outcomes Following Kidney Transplantation by Dessing, Mark C, Kers, Jesper, Damman, Jeffrey, Leuvenink, Henri G D, van Goor, Harry, Hillebrands, Jan-Luuk, Hepkema, Bouke G, Snieder, Harold, van den Born, Jacob, de Borst, Martin H, Bakker, Stephan J L, Navis, Gerjan J, Ploeg, Rutger J, Florquin, Sandrine, Seelen, Marc, Leemans, Jaklien C

“…Toll-like receptors (TLRs) play a crucial role in innate- and adaptive immunity. The TLR pathways were shown to play key functional roles in experimental acute…”
Get full text

UMOD as a susceptibility gene for end-stage renal disease by Reznichenko, Anna, Böger, Carsten A, Snieder, Harold, van den Born, Jacob, de Borst, Martin H, Damman, Jeffrey, van Dijk, Marcory C R F, van Goor, Harry, Hepkema, Bouke G, Hillebrands, Jan-Luuk, Leuvenink, Henri G D, Niesing, Jan, Bakker, Stephan J L, Seelen, Marc, Navis, Gerjan

“…In recent genetic association studies, common variants including rs12917707 in the UMOD locus have shown strong evidence of association with eGFR, prevalent…”
Get full text

CUBN as a novel locus for end-stage renal disease: insights from renal transplantation by Reznichenko, Anna, Snieder, Harold, van den Born, Jacob, de Borst, Martin H, Damman, Jeffrey, van Dijk, Marcory C R F, van Goor, Harry, Hepkema, Bouke G, Hillebrands, Jan-Luuk, Leuvenink, Henri G D, Niesing, Jan, Bakker, Stephan J L, Seelen, Marc, Navis, Gerjan

“…Chronic kidney disease (CKD) is a complex disorder. As genome-wide association studies identified cubilin gene CUBN as a locus for albuminuria, and urinary…”
Get full text

Recipient's genetic R702W NOD2 variant is associated with an increased risk of bacterial infections after orthotopic liver transplantation by Janse, Marcel, de Rooij, Bert-Jan F, van Hoek, Bart, van den Berg, Arie P, Porte, Robert J, Blokzijl, Hans, Coenraad, Minneke J, Hepkema, Bouke G, Schaapherder, Alexander F, Ringers, Jan, Weersma, Rinse K, Verspaget, Hein W

“…Orthotopic liver transplantation (OLT) is accompanied by a significant postoperative infection risk. Immunosuppression to prevent rejection increases the…”
Get full text

HLA‐B51:197: A composite product of interlocus recombination of B51:01:01:01 and C01:02:01:01 by Kouprie, Niels, Bungener, Laura B., Lambeck, Annechien J. A., Kroesen, Bart‐Jan, Hepkema, Bouke G.

“…The HLA‐B*51:197 allele is generated from the interlocus recombination of both HLA‐B*51:01:01:01 and HLA‐C*01:02:01:01 alleles…”
Get full text

CCR5Δ32 genotype leads to a Th2 type directed immune response in ESRD patients by Muntinghe, Friso L H, Abdulahad, Wayel H, Huitema, Minke G, Damman, Jeffrey, Seelen, Marc A, Lems, Simon P M, Hepkema, Bouke G, Navis, Gerjan, Westra, Johanna

“…In patients with end stage renal disease (ESRD) we observed protection from inflammation-associated mortality in CCR5Δ32 carriers, leading to CCR5 deficiency,…”
Get full text

Successful lung transplantation in the presence of pre-existing donor-specific cytotoxic HLA Class II antibodies by Lambeck, Annechien J.A., PhD, Verschuuren, Erik A., MD, PhD, Bouwman, Ilby, Jongsma, Theo, Roozendaal, Caroline, PhD, Bungener, Laura B., PhD, van der Bij, Wim, MD, PhD, van den Berg, Aad P., MD, Erasmus, Michiel E., MD, PhD, Timens, Wim, MD,PhD, Lems, Simon P.M., PhD, Hepkema, Bouke G., PhD

“…Pre-existing HLA antibodies are a well-established causal factor for rejection and graft dysfunction after solid-organ transplantation. In lung transplant…”
Get full text

Resolving unknown nucleotides in the IPD-IMGT/HLA database by extended and full-length sequencing of HLA class I and II alleles by Voorter, Christina E. M., Groeneweg, Mathijs, Olieslagers, Timo I., Fae, Ingrid, Fischer, Gottfried F., Andreani, Marco, Troiano, Maria, Vidan-Jeras, Blanka, Montanic, Sendi, Hepkema, Bouke G., Bungener, Laura B., Tilanus, Marcel G. J., Wieten, Lotte

“…In the past, identification of HLA alleles was limited to sequencing the region of the gene coding for the peptide binding groove, resulting in a lack of…”
Get full text

Quantification of Epstein-Barr Virus–DNA Load in Lung Transplant Recipients: A Comparison of Plasma versus Whole Blood by Bakker, Nicolaas A., MD, PhD, Verschuuren, Erik A., MD, PhD, Veeger, Nic J., MSc, van der Bij, Wim, MD, PhD, van Imhoff, Gustaaf W., MD, PhD, Kallenberg, Cees G., MD, PhD, Hepkema, Bouke G., PhD

“…Background Monitoring of the Epstein-Barr virus–DNA load is frequently used to identify patients at risk for post-transplant lymphoproliferative disease…”
Get full text

Antibodies against ARHGDIB are associated with long‐term kidney graft loss by Kamburova, Elena G., Gruijters, Maartje L., Kardol‐Hoefnagel, Tineke, Wisse, Bram W., Joosten, Irma, Allebes, Wil A., Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., Reekum, Franka E., Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C. A. D., Plaisier, Loes, Melchers, Rowena C. A., Seelen, Marc A. J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J. A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G. J., Voorter, Christina E., Wieten, Lotte, Duijnhoven, Elly M., Gelens, Mariëlle A. C. J., Christiaans, Maarten H. L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, Pant, Karlijn A. M. I., Weerd, Neelke C., Berge, Ineke J. M., Hoitsma, Andries, Boog, Paul J. M., de Fijter, Johan W., Betjes, Michiel G. H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., Bemelman, Frederike J., Otten, Henny G.

“…The clinical significance of non‐HLA antibodies on renal allograft survival is a matter of debate, due to differences in reported results and lack of…”
Get full text

Pretransplant NT-proBNP, Dialysis Vintage, and Posttransplant Mortality in Kidney Transplant Recipients by Yeung, Stanley M.H., van Londen, Marco, Nakshbandi, Uzma, Said, M. Yusof, Eisenga, Michele F., Hepkema, Bouke G., Nolte, Ilja M., Berger, Stefan P., de Borst, Martin H., Bakker, Stephan J.L.

“…BACKGROUND.End-stage kidney disease and dialysis vintage are characterized by accelerated atherosclerosis, volume overload, and progressive left ventricular…”
Get full text