Search Results - "Hepburn, P"

Safety evaluation of phytosterol-esters. Part 9: Results of a European post-launch monitoring programme by Lea, L.J., Hepburn, P.A.

“…Phytosterol-esters were developed by Unilever as a cholesterol lowering novel food ingredient for use initially in vegetable oil spreads. In addition to an…”
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History of safe use as applied to the safety assessment of novel foods and foods derived from genetically modified organisms by Constable, A., Jonas, D., Cockburn, A., Davi, A., Edwards, G., Hepburn, P., Herouet-Guicheney, C., Knowles, M., Moseley, B., Oberdörfer, R., Samuels, F.

“…Very few traditional foods that are consumed have been subjected to systematic toxicological and nutritional assessment, yet because of their long history and…”
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The application of post-market monitoring to novel foods by Hepburn, P., Howlett, J., Boeing, H., Cockburn, A., Constable, A., Davi, A., de Jong, N., Moseley, B., Oberdörfer, R., Robertson, C., Wal, J.M., Samuels, F.

“…The role of post-market monitoring (PMM) in the safety assessment of novel foods is critically discussed in order to derive guidelines as to in which…”
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Safety evaluation of phytosterol esters. Part 8. Lack of genotoxicity and subchronic toxicity with phytosterol oxides by Lea, L.J, Hepburn, P.A, Wolfreys, A.M, Baldrick, P

“…Vegetable oil spreads containing phytosterol-esters are marketed as a cholesterol-lowering functional food in more than 20 countries worldwide. An extensive…”
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The safety evaluation of phytosterol esters. Part 6. The comparative absorption and tissue distribution of phytosterols in the rat by Sanders, D.J, Minter, H.J, Howes, D, Hepburn, P.A

“…As part of an extensive safety evaluation programme, a series of studies has been conducted to determine the fate of phytosterols in the rat. Rats were dosed…”
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Safety Evaluation of Phytosterol Esters. Part 2. Subchronic 90-Day Oral Toxicity Study on Phytosterol Esters–A Novel Functional Food by Hepburn, P.A., Horner, S.A., Smith, M.

“…Phytosterol esters (PE) are intended for use as a novel food ingredient, primarily in margarines and spreads as a functional component with plasma cholesterol…”
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Safety evaluation of phytosterol esters. Part 7. Assessment of mutagenic activity of phytosterols, phytosterol esters and the cholesterol derivative, 4-cholesten-3-one by Wolfreys, A.M., Hepburn, P.A.

“…Phytosterol esters are phytosterols derived from vegetable oils following esterification to fatty acids. When phytosterols are added to foods, they inhibit the…”
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Safety evaluation of phytosterol esters. Part 1. Assessment of oestrogenicity using a combination of in vivo and in vitro assays by Baker, V.A, Hepburn, P.A, Kennedy, S.J, Jones, P.A, Lea, L.J, Sumpter, J.P, Ashby, J

“…Phytosterols are natural constituents of the human diet, and as part of an extensive programme of safety evaluation studies investigating their use as a novel…”
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Causality methods in Cosmetovigilance: Comparison of Colipa and PLM versus global introspection by Zweers, P.G.M.A., Gilmour, N.J., Hepburn, P.A., Gerritsen, R.F., van Puijenbroek, E.P.

“…► Colipa and PLM provide causality schemes used in Cosmetovigilance. ► Both schemes were validated against clinical assessment (global introspection). ► The…”
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Safety evaluation of phytosterol esters. Part 5. Faecal short-chain fatty acid and microflora content, faecal bacterial enzyme activity and serum female sex hormones in healthy normolipidaemic volunteers consuming a controlled diet either with or without a phytosterol ester-enriched margarine by Ayesh, R, Weststrate, J.A, Drewitt, P.N, Hepburn, P.A

“…A study was conducted in 12 healthy males and 12 healthy females (mean age 36 years, mean body mass index 24 kg/m 2), to determine the effect of a margarine…”
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Evidence for a Telomere-Independent “Clock” Limiting RAS Oncogene-Driven Proliferation of Human Thyroid Epithelial Cells by Jones, C. J., Kipling, D., Morris, M., Hepburn, P., Skinner, J., Bounacer, A., Wyllie, F. S., Ivan, M., Bartek, J., Wynford-Thomas, D., Bond, J. A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Safety Evaluation of Phytosterol Esters. Part 3. Two-Generation Reproduction Study in Rats with Phytosterol Esters—a Novel Functional Food by Waalkens-Berendsen, D.H, Wolterbeek, A.P.M, Wijnands, M.V.W, Richold, M, Hepburn, P.A

“…Phytosterol esters (PE) are intended for use as a novel food ingredient with plasma cholesterol lowering activity which works by inhibiting the absorption of…”
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Post-market surveillance of GM foods: applicability and limitations of schemes used with pharmaceuticals and some non-GM novel foods by Wal, J.-M, Hepburn, P.A, Lea, L.J, Crevel, R.W.R

“…Post-market surveillance (PMS) is increasingly required by some regulatory authorities for the marketing approval of GM-Novel Foods. This requirement, in…”
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An investigation of the general, reproductive and postnatal developmental toxicity of Betapol™, a human milk fat equivalent by Spurgeon, M.J, Palmer, A.K, Hepburn, P.A

“…Betapol™ consists of triglyceride fatty acids commonly found in vegetable and animal fats. A similarity to human milk fat indicated a potential use in infant…”
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An assessment of the carcinogenic potential of shea oleine in the rat by Carthew, P., Baldrick, P., Hepburn, P.A.

“…Shea oleine, an oil fraction derived from the nut of the tree Butyrospermum parkii, is used as a frying oil. As part of a series of studies, this investigation…”
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The safety assessment of novel foods and concepts to determine their safety in use

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Reproduction studies in the rat with shea oleine and hardened shea oleine by Baldrick, P, Robinson, J.A, Hepburn, P.A

“…Shea oleine is an oil fraction derived from the nut of the tree Butyrospermum parkii, which grows in central and western Africa. There are several uses of shea…”
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Post Launch Monitoring of food products: What can be learned from pharmacovigilance by van Puijenbroek, E.P., Hepburn, P.A., Herd, T.M., van Grootheest, A.C.

“…Post Launch Monitoring (PLM) is one of the new approaches that are used in assessing the safety of novel foods or ingredients. It shares a close resemblance…”
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LIFE COURSE EFFECTS OF UNEMPLOYMENT ON THE ONSET OF MAJOR HEALTH CONDITIONS AT OLDER AGES by Harrati, A, Hepburn, P

“…There is substantial evidence that unemployment is associated with adverse health. However, current studies are often limited in two ways. First, effects on…”
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A randomized trial of amifostine as a cytoprotective agent in patients receiving chemotherapy for small cell lung cancer by JOHNSON, P. W. M, MUERS, M. F, PEAKE, M. D, POULTER, K. M, GURNEY, E. M, NAPP, V, HEPBURN, P. M, BROWN, J. M

“…A randomized trial was conducted to determine whether administration of Amifostine with chemotherapy for small cell lung cancer could decrease the toxicity. 84…”
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