Search Results - "Hepatology research : the official journal of the Japan Society of Hepatology"

Role of sorafenib in the treatment of advanced hepatocellular carcinoma: An update by Gauthier, Angela, Ho, Mitchell

“…Sorafenib is the first and only p.o. administrated drug currently approved to treat advanced hepatocellular carcinoma (HCC). However, concerns have been raised…”
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Oxidative stress and liver disease by Zhu, Runzhi, Wang, Yajing, Zhang, Liangqing, Guo, Qinglong

“…In humans, oxidative stress and antioxidant defenses are the sum of a complicated network of enzymatic and non‐enzymatic processes. Depending on the stage and…”
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Liver and diabetes. A vicious circle by Loria, Paola, Lonardo, Amedeo, Anania, Frank

“…The complex and bi‐directional relationship linking the liver and diabetes has recently gained intense new interest. This critical review of the published work…”
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Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: Association with MMP-9 by Chen, Jing-song, Wang, Qian, Fu, Xin-hui, Huang, Xiao-Hui, Chen, Xi-lin, Cao, Liang-qi, Chen, Lian-zhou, Tan, Hao-xiang, Li, Wen, Bi, Jiong, Zhang, Long-juan

“…Aim:  To investigate the status of Phosphatidylinositol 3‐kinase (PI3K)/PTEN/AKT/mammalian target of rapamycin (mTOR) pathway and its correlation with…”
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Epidemiology of hepatitis B virus in Africa, its genotypes and clinical associations of genotypes by Kramvis, Anna, Kew, Michael C.

“…Of approximately 360 million people in the world chronically infected with hepatitis B virus (HBV), 65 million reside in Africa. Thus, Africa, with 12% of the…”
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Etiology and prognosis of fulminant hepatitis and late-onset hepatic failure in Japan: Summary of the annual nationwide survey between 2004 and 2009 by Oketani, Makoto, Ido, Akio, Nakayama, Nobuaki, Takikawa, Yasuhiro, Naiki, Takafumi, Yamagishi, Yoshiyuki, Ichida, Takafumi, Mochida, Satoshi, Onishi, Saburo, Tsubouchi, Hirohito

“…Aim To summarize the annual nationwide survey on fulminant hepatitis (FH) and late‐onset hepatic failure (LOHF) between 2004 and 2009 in Japan. Methods The…”
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Report of the 17th Nationwide Follow-up Survey of Primary Liver Cancer in Japan by Ikai, Iwao, Arii, Shigeki, Okazaki, Masatoshi, Okita, Kiwamu, Omata, Masao, Kojiro, Masamichi, Takayasu, Kenichi, Nakanuma, Yasuni, Makuuchi, Masatoshi, Matsuyama, Yutaka, Monden, Morito, Kudo, Masatoshi

“…In the 17th Nationwide Follow‐up Survey of Primary Liver Cancer in Japan, 18 213 individuals were newly registered as patients with primary liver cancer at 645…”
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Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease by Higuchi, Nobito, Kato, Masaki, Shundo, Yuki, Tajiri, Hirotaka, Tanaka, Masatake, Yamashita, Naoki, Kohjima, Motoyuki, Kotoh, Kazuhiro, Nakamuta, Makoto, Takayanagi, Ryoichi, Enjoji, Munechika

“…Aim:  Nonalcoholic fatty liver disease (NAFLD) is one of the most frequent causes of liver dysfunction and its incidence has increased markedly. However, the…”
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Development of evidence‐based clinical guidelines for the diagnosis and treatment of hepatocellular carcinoma in Japan by Makuuchi, Masatoshi, Kokudo, Norihiro, Arii, Shigeki, Futagawa, Shunji, Kaneko, Shuichi, Kawasaki, Seiji, Matsuyama, Yutaka, Okazaki, Masatoshi, Okita, Kiwamu, Omata, Masao, Saida, Yukihisa, Takayama, Tadatoshi, Yamaoka, Yoshio

“…The Clinical Practice Guidelines for Hepatocellular Carcinoma (HCC), the first evidence‐based guidelines for the treatment of HCC in Japan, were compiled by an…”
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NASH: A global health problem by Sanyal, Arun J.

“…Non‐alcoholic fatty liver disease (NAFLD) is a major public health problem both in the Western world and in the East. This is mainly due to the high prevalence…”
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Geographical and genetic diversity of the human hepatitis B virus by Kurbanov, Fuat, Tanaka, Yasuhito, Mizokami, Masashi

“…Hepatitis B virus (HBV) is one of the most widely distributed viruses that infect humankind. Distinct clinical and virological characteristics of the…”
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Management of hepatocellular carcinoma: Report of Consensus Meeting in the 45th Annual Meeting of the Japan Society of Hepatology (2009) by Arii, Shigeki, Sata, Michio, Sakamoto, Michiie, Shimada, Mitsuo, Kumada, Takashi, Shiina, Shuichiro, Yamashita, Tatsuya, Kokudo, Norihiro, Tanaka, Masatoshi, Takayama, Tadatoshi, Kudo, Masatoshi

“…Hepatocellular carcinoma (HCC) is responsible for approximately 600 000–700 000 deaths worldwide. It is highly prevalent in the Asia–Pacific region and Africa,…”
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Associations among liver disease, serum lipid profile, body mass index, ketonuria, meal skipping, and the alcohol dehydrogenase‐1B and aldehyde dehydrogenase‐2 genotypes in Japanese men with alcohol dependence by Yokoyama, Akira, Taniki, Nobuhito, Nakamoto, Nobuhiro, Tomita, Kengo, Hara, Sachiko, Mizukami, Takeshi, Maruyama, Katsuya, Yokoyama, Tetsuji

“…Aim To elucidate associations among liver disease, lipid profile, body mass index (BMI), ketonuria, and meal skipping under the influence of alcohol…”
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Epidemiology of hepatocellular carcinoma in USA by El-Serag, Hashem B.

“…Hepatocellular carcinoma (HCC) is increasing in frequency the USA. Age‐adjusted incidence, hospitalization, and mortality rates have doubled over the past two…”
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Diagnostic criteria of acute liver failure: A report by the Intractable Hepato-Biliary Diseases Study Group of Japan by Mochida, Satoshi, Takikawa, Yasuhiro, Nakayama, Nobuaki, Oketani, Makoto, Naiki, Takafumi, Yamagishi, Yoshiyuki, Ichida, Takafumi, Tsubouchi, Hirohito

“…The diagnostic criteria of fulminant hepatitis in Japan are different from those of acute liver failure in Europe and the United States, both in regard to the…”
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Report of the 18th follow-up survey of primary liver cancer in Japan by Ikai, Iwao, Kudo, Masatoshi, Arii, Shigeki, Omata, Masao, Kojiro, Masamichi, Sakamoto, Michiie, Takayasu, Kenichi, Hayashi, Norio, Makuuchi, Masatoshi, Matsuyama, Yutaka, Monden, Morito

“…In the 18th Nationwide Follow‐Up Survey of Primary Liver Cancer in Japan, 20 753 people were newly registered as patients with primary liver cancer at 544…”
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Sepsis-associated liver injury: Incidence, classification and the clinical significance by Kobashi, Haruhiko, Toshimori, Junichi, Yamamoto, Kazuhide

“…Aim:  Although it is a common complication of sepsis, sepsis‐associated liver injury has not been substantially recognized, because its diagnostic criteria and…”
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Enzyme-linked immunosorbent serum assay specific for the 7S domain of Collagen Type IV (P4NP 7S): A marker related to the extracellular matrix remodeling during liver fibrogenesis by Leeming, Diana J., Nielsen, Mette J., Dai, Yueqin, Veidal, Sanne S., Vassiliadis, Efstathios, Zhang, Chen, He, Yi, Vainer, Ben, Zheng, Qinlong, Karsdal, Morten A.

“…Aim:  The present study describes the ability of a newly developed N‐terminal pro‐peptides of type IV collagen 7S domain (P4NP 7S) competitive enzyme‐linked…”
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Assessment of liver function for safe hepatic resection by Seyama, Yasuji, Kokudo, Norihiro

“…The preoperative assessment of liver function is extremely important for preventing postoperative liver failure and mortality after hepatic resection. Liver…”
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Hepatocellular carcinoma in non-alcoholic steatohepatitis: Growing evidence of an epidemic? by Hashimoto, Etsuko, Tokushige, Katsutoshi

“…The incidence of hepatocellular carcinoma in non‐viral‐related chronic liver disease has gradually increased in Japan. Obesity and diabetes mellitus type 2…”
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