Search Results - "Heo, Kyun"

TSPAN8 as a Novel Emerging Therapeutic Target in Cancer for Monoclonal Antibody Therapy by Heo, Kyun, Lee, Sukmook

“…Tetraspanin 8 (TSPAN8) is a member of the tetraspanin superfamily that forms TSPAN8-mediated protein complexes by interacting with themselves and other various…”
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Catecholamines Promote Ovarian Cancer Progression through Secretion of CXC-Chemokines by Kim, Hyun Jung, Chang, Ha Kyun, Lee, Yul Min, Heo, Kyun

“…Considerable evidence has accumulated in the last decade supporting the notion that chronic stress is closely related to the growth, metastasis, and…”
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G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion by Lee, Yu Jin, Shin, Kyeong Jin, Park, Soo-Ah, Park, Kyeong Su, Park, Seorim, Heo, Kyun, Seo, Young-Kyo, Noh, Dong-Young, Ryu, Sung Ho, Suh, Pann-Ghill

“…G-protein-coupled receptor 81 (GPR81) functions as a receptor for lactate and plays an important role in the regulation of anti-lipolytic effects in…”
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A dual-targeting approach using a human bispecific antibody against the receptor-binding domain of the Middle East Respiratory Syndrome Coronavirus by Lee, Ji Hyun, Kim, Ji Woong, Lee, Hee Eon, Song, Jin Young, Cho, Ah Hyun, Hwang, Jae Hyeon, Heo, Kyun, Lee, Sukmook

“…•Isolation of human monoclonal antibodies (mAbs) against MERS-CoV RBD through phage display.•Development of potent bispecific antibodies (bsAbs) targeting the…”
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An internalizing antibody targeting of cell surface GRP94 effectively suppresses tumor angiogenesis of colorectal cancer by Cho, Yea Bin, Kim, Ji Woong, Heo, Kyun, Kim, Hyun Jung, Yun, Sumi, Lee, Hye Seung, Shin, Ha Gyeong, Shim, Hyunbo, Yu, Hanjin, Kim, Yun-Hee, Lee, Sukmook

“…Colorectal cancer (CRC) is one of the life-threatening malignancies worldwide. Thus, novel potential therapeutic targets and therapeutics for the treatment of…”
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Targeting cell surface glucose-regulated protein 94 in gastric cancer with an anti-GRP94 human monoclonal antibody by Kim, Hyun Jung, Cho, Yea Bin, Heo, Kyun, Kim, Ji Woong, Shin, Ha Gyeong, Lee, Eun-Bi, Park, Seong-Min, Park, Jong Bae, Lee, Sukmook

“…Gastric cancer (GC), a leading cause of cancer-related mortality, remains a significant challenge despite recent therapeutic advancements. In this study, we…”
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A novel bispecific antibody dual-targeting approach for enhanced neutralization against fast-evolving SARS-CoV-2 variants by Kim, Ji Woong, Kim, Hyun Jung, Heo, Kyun, Lee, Yoonwoo, Jang, Hui Jeong, Lee, Ho-Young, Park, Jun Won, Cho, Yea Bin, Lee, Ji Hyun, Shin, Ha Gyeong, Yang, Ha Rim, Choi, Hye Lim, Shim, Hyun Bo, Lee, Sukmook

“…Introduction The emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has caused unprecedented health and socioeconomic…”
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Gramicidin, a Bactericidal Antibiotic, Is an Antiproliferative Agent for Ovarian Cancer Cells by Choi, Min Sung, Lee, Chae Yeon, Kim, Ji Hyeon, Lee, Yul Min, Lee, Sukmook, Kim, Hyun Jung, Heo, Kyun

“…: Gramicidin, a bactericidal antibiotic used in dermatology and ophthalmology, has recently garnered attention for its inhibitory actions against cancer cell…”
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CLEC14a-HSP70-1A interaction regulates HSP70-1A-induced angiogenesis by Jang, Jihye, Kim, Mi Ra, Kim, Taek-Keun, Lee, Woo Ran, Kim, Jong Heon, Heo, Kyun, Lee, Sukmook

“…CLEC14a (C-type lectin domain family 14 member) is a tumor endothelial cell marker protein that is known to play an important role in tumor angiogenesis, but…”
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Therapeutic Application of Drug-Conjugated HER2 Oligobody (HER2-DOligobody) by Kim, Hyun Jung, Sung, Ho Jin, Lee, Yul Min, Choi, Sun Il, Kim, Yun-Hee, Heo, Kyun, Kim, In-Hoo

“…Antibody drug conjugates (ADCs), consisting of a cancer-specific antibody and cytotoxic payload, are shown to be a potent class of anticancer therapeutics,…”
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Inhibition of BMP signaling overcomes acquired resistance to cetuximab in oral squamous cell carcinomas by Yin, Jinlong, Jung, Ji-Eun, Choi, Sun Il, Kim, Sung Soo, Oh, Young Taek, Kim, Tae-Hoon, Choi, Eunji, Lee, Sun Joo, Kim, Hana, Kim, Eun Ok, Lee, Yu Sun, Chang, Hee Jin, Park, Joo Yong, Kim, Yeejeong, Yun, Tak, Heo, Kyun, Kim, Youn-Jae, Kim, Hyunggee, Kim, Yun-Hee, Park, Jong Bae, Choi, Sung Weon

“…Despite expressing high levels of the epidermal growth factor receptor (EGFR), a majority of oral squamous cell carcinoma (OSCC) patients show limited response…”
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Inhibition of VEGF‐dependent angiogenesis and tumor angiogenesis by an optimized antibody targeting CLEC14a by Kim, Taek‐Keun, Park, Chang Sik, Jang, Jihye, Kim, Mi Ra, Na, Hee‐Jun, Lee, Kangseung, Kim, Hyun Jung, Heo, Kyun, Yoo, Byong Chul, Kim, Young‐Myeong, Lee, Je‐Wook, Kim, Su Jin, Kim, Eun Sung, Kim, Dae Young, Cha, Kiweon, Lee, Tae Gyu, Lee, Sukmook

“…The C‐type lectin‐like domain of CLEC14a (CLEC14a‐C‐type lectin‐like domain [CTLD]) is a key domain that mediates endothelial cell–cell contacts in…”
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Gentian Violet Inhibits Cell Proliferation through Induction of Apoptosis in Ovarian Cancer Cells by Choi, Min Sung, Kim, Ji Hyeon, Lee, Chae Yeon, Lee, Yul Min, Lee, Sukmook, Chang, Ha Kyun, Kim, Hyun Jung, Heo, Kyun

“…Gentian violet (GV) is known to have antibacterial and antifungal effects, but recent studies have demonstrated its inhibitory effects on the growth of several…”
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Humanized Anti-hepatocyte Growth Factor Monoclonal Antibody (YYB-101) Inhibits Ovarian Cancer Progression by Kim, Hyun Jung, Lee, Sukmook, Oh, Yong-Seok, Chang, Ha Kyun, Kim, Young Sang, Hong, Sung Hee, Kim, Jung Yong, Park, Young-Whan, Lee, Song-Jae, Song, Seong-Won, Kim, Jung Ju, Heo, Kyun

“…Current chemotherapy regimens have certain limitations in improving the survival rates of patients with advanced ovarian cancer. Hepatocyte growth factor (HGF)…”
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Dynamic relocalization of NHERF1 mediates chemotactic migration of ovarian cancer cells toward lysophosphatidic acid stimulation by Oh, Yong-Seok, Heo, Kyun, Kim, Eung-Kyun, Jang, Jin-Hyeok, Bae, Sun Sik, Park, Jong Bae, Kim, Yun Hee, Song, Minseok, Kim, Sang Ryong, Ryu, Sung Ho, Kim, In-Hoo, Suh, Pann-Ghill

“…NHERF1/EBP50 (Na + /H + exchanger regulating factor 1; Ezrin-binding phosphoprotein of 50 kDa) organizes stable protein complexes beneath the apical membrane…”
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Antibody-Based Targeting of Cell Surface GRP94 Specifically Inhibits Cetuximab-Resistant Colorectal Cancer Growth by Jeoung, Mee Hyun, Kim, Taek-Keun, Kim, Ji Woong, Cho, Yea Bin, Na, Hee Jun, Yoo, Byong Chul, Shim, Hyunbo, Song, Dong-Keun, Heo, Kyun, Lee, Sukmook

“…Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide. Cetuximab, a human/mouse chimeric monoclonal antibody, is effective in a…”
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Repurposing Valrubicin as a Potent Inhibitor of Ovarian Cancer Cell Growth by Lee, Jaeeun, Heo, Kyun

“…Ovarian cancer (OC) is a leading cause of cancer-related mortality among women, and there remains a significant unmet need for new therapeutic agents to…”
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Identification of a compound that directly stimulates phospholipase C activity by Bae, Yoe-Sik, Lee, Taehoon G, Park, Jun Chul, Hur, Jung Ho, Kim, Youndong, Heo, Kyun, Kwak, Jong-Young, Suh, Pann-Ghill, Ryu, Sung Ho

“…Phosphoinositide-specific phospholipase C (PLC) plays a pivotal role in the signal transduction of various cellular responses. However, although it is…”
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Abstract 3950: Extracellular protons promote the metastasis of breast cancer via activation of the proton-sensing receptor G-protein coupled receptor 4 by Lee, Yu Jin, Heo, Kyun, Park, Soo-Ah, Noh, Dong-Young, Kim, Kyong-Tai, Ryu, Sung Ho, Suh, Pann-Ghill Suh

“…Abstract Acidosis of the tumor microenvironment is a typical malignant phenotype that enhances tumorigenesis and tumor progression induced by altered cellular…”
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Therapeutic aptamers: developmental potential as anticancer drugs by Lee, Ji Won, Kim, Hyun Jung, Heo, Kyun

“…Aptamers, composed of single-stranded DNA or RNA oligonucleotides that interact with target molecules through a specific three-dimensional structure, are…”
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