Search Results - "Henzler, Christine"

Molecular Mechanism for Plant Steroid Receptor Activation by Somatic Embryogenesis Co-Receptor Kinases by Santiago, Julia, Henzler, Christine, Hothorn, Michael

“…Brassinosteroids, which control plant growth and development, are sensed by the leucine-rich repeat (LRR) domain of the membrane receptor kinase…”
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Diverse AR Gene Rearrangements Mediate Resistance to Androgen Receptor Inhibitors in Metastatic Prostate Cancer by Li, Yingming, Yang, Rendong, Henzler, Christine M, Ho, Yeung, Passow, Courtney, Auch, Benjamin, Carreira, Suzanne, Nava Rodrigues, Daniel, Bertan, Claudia, Hwang, Tae Hyun, Quigley, David A, Dang, Ha X, Morrissey, Colm, Fraser, Michael, Plymate, Stephen R, Maher, Christopher A, Feng, Felix Y, de Bono, Johann S, Dehm, Scott M

“…Prostate cancer is the second leading cause of male cancer deaths. Castration-resistant prostate cancer (CRPC) is a lethal stage of the disease that emerges…”
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Thymic regulatory T cells arise via two distinct developmental programs by Owen, David L., Mahmud, Shawn A., Sjaastad, Louisa E., Williams, Jason B., Spanier, Justin A., Simeonov, Dimitre R., Ruscher, Roland, Huang, Weishan, Proekt, Irina, Miller, Corey N., Hekim, Can, Jeschke, Jonathan C., Aggarwal, Praful, Broeckel, Ulrich, LaRue, Rebecca S., Henzler, Christine M., Alegre, Maria-Luisa, Anderson, Mark S., August, Avery, Marson, Alexander, Zheng, Ye, Williams, Calvin B., Farrar, Michael A.

“…The developmental programs that generate a broad repertoire of regulatory T cells (T reg cells) able to respond to both self antigens and non-self antigens…”
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Impact of protein kinase CK2 downregulation and inhibition on oncomir clusters 17 ~ 92 and 106b ~ 25 in prostate, breast, and head and neck cancers by Kren, Betsy T, Henzler, Christine M, Ahmed, Khalil, Trembley, Janeen H

“…Protein kinase CK2 is a ubiquitous and highly conserved protein Ser/Thr kinase with diverse cell functions. CK2 is upregulated in various cancers and affects…”
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Lineage-Specific Effector Signatures of Invariant NKT Cells Are Shared amongst gamma delta T, Innate Lymphoid, and Th Cells by Lee, You Jeong, Starrett, Gabriel J, Lee, Seungeun Thera, Yang, Rendong, Henzler, Christine M, Jameson, Stephen C, Hogquist, Kristin A

“…Invariant NKT cells differentiate into three predominant effector lineages in the steady state. To understand these lineages, we sorted undifferentiated…”
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Multiomic Analysis of Subtype Evolution and Heterogeneity in High-Grade Serous Ovarian Carcinoma by Geistlinger, Ludwig, Oh, Sehyun, Ramos, Marcel, Schiffer, Lucas, LaRue, Rebecca S, Henzler, Christine M, Munro, Sarah A, Daughters, Claire, Nelson, Andrew C, Winterhoff, Boris J, Chang, Zenas, Talukdar, Shobhana, Shetty, Mihir, Mullany, Sally A, Morgan, Martin, Parmigiani, Giovanni, Birrer, Michael J, Qin, Li-Xuan, Riester, Markus, Starr, Timothy K, Waldron, Levi

“…Multiple studies have identified transcriptome subtypes of high-grade serous ovarian carcinoma (HGSOC), but their interpretation and translation are…”
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Seascape genetics and the spatial ecology of marine populations by Selkoe, Kimberly A, Henzler, Christine M, Gaines, Steven D

“…Molecular tools perform at their best when integrated with other data and approaches. The value of integrating approaches is especially high when the…”
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Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy by Kren, Betsy T, Unger, Gretchen M, Abedin, Md J, Vogel, Rachel I, Henzler, Christine M, Ahmed, Khalil, Trembley, Janeen H

“…Targeted therapies for aggressive breast cancers like triple negative breast cancer (TNBC) are needed. The use of small interfering RNAs (siRNAs) to disable…”
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Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells by Burrack, Kristina S., Huggins, Matthew A., Taras, Emily, Dougherty, Philip, Henzler, Christine M., Yang, Rendong, Alter, Sarah, Jeng, Emily K., Wong, Hing C., Felices, Martin, Cichocki, Frank, Miller, Jeffrey S., Hart, Geoffrey T., Johnson, Aaron J., Jameson, Stephen C., Hamilton, Sara E.

“…Cerebral malaria is a deadly complication of Plasmodium infection and involves blood brain barrier (BBB) disruption following infiltration of white blood…”
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Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer by Henzler, Christine, Li, Yingming, Yang, Rendong, McBride, Terri, Ho, Yeung, Sprenger, Cynthia, Liu, Gang, Coleman, Ilsa, Lakely, Bryce, Li, Rui, Ma, Shihong, Landman, Sean R., Kumar, Vipin, Hwang, Tae Hyun, Raj, Ganesh V., Higano, Celestia S., Morrissey, Colm, Nelson, Peter S., Plymate, Stephen R., Dehm, Scott M.

“…Molecularly targeted therapies for advanced prostate cancer include castration modalities that suppress ligand-dependent transcriptional activity of the…”
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Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival by Katerndahl, Casey D S, Heltemes-Harris, Lynn M, Willette, Mark J L, Henzler, Christine M, Frietze, Seth, Yang, Rendong, Schjerven, Hilde, Silverstein, Kevin A T, Ramsey, Laura B, Hubbard, Gregory, Wells, Andrew D, Kuiper, Roland P, Scheijen, Blanca, van Leeuwen, Frank N, Müschen, Markus, Kornblau, Steven M, Farrar, Michael A

“…Transcription factors compete for superenhancer sites and have antagonist functions. Farrar and colleagues identify regulatory competition between STAT5 and…”
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Cerebellar Transcriptome Profiles of ATXN1 Transgenic Mice Reveal SCA1 Disease Progression and Protection Pathways by Ingram, Melissa, Wozniak, Emily A.L., Duvick, Lisa, Yang, Rendong, Bergmann, Paul, Carson, Robert, O’Callaghan, Brennon, Zoghbi, Huda Y., Henzler, Christine, Orr, Harry T.

“…SCA1, a fatal neurodegenerative disorder, is caused by a CAG expansion encoding a polyglutamine stretch in the protein ATXN1. We used RNA sequencing to profile…”
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ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism by Rousseaux, Maxime W.C., Tschumperlin, Tyler, Lu, Hsiang-Chih, Lackey, Elizabeth P., Bondar, Vitaliy V., Wan, Ying-Wooi, Tan, Qiumin, Adamski, Carolyn J., Friedrich, Jillian, Twaroski, Kirk, Chen, Weili, Tolar, Jakub, Henzler, Christine, Sharma, Ajay, Bajić, Aleksandar, Lin, Tao, Duvick, Lisa, Liu, Zhandong, Sillitoe, Roy V., Zoghbi, Huda Y., Orr, Harry T.

“…Polyglutamine (polyQ) diseases are caused by expansion of translated CAG repeats in distinct genes leading to altered protein function. In spinocerebellar…”
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Targeting a Single Alternative Polyadenylation Site Coordinately Blocks Expression of Androgen Receptor mRNA Splice Variants in Prostate Cancer by Van Etten, Jamie L, Nyquist, Michael, Li, Yingming, Yang, Rendong, Ho, Yeung, Johnson, Rachel, Ondigi, Olivia, Voytas, Daniel F, Henzler, Christine, Dehm, Scott M

“…Prostate cancer is the second leading cause of male cancer deaths due to disease progression to castration-resistant prostate cancer (CRPC). Androgen receptor…”
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Identification of mutations that cooperate with defects in B cell transcription factors to initiate leukemia by Heltemes-Harris, Lynn M., Hubbard, Gregory K., LaRue, Rebecca S., Munro, Sarah A., Yang, Rendong, Henzler, Christine M., Starr, Timothy K., Sarver, Aaron L., Kornblau, Steven M., Farrar, Michael A.

“…The transcription factors PAX5, IKZF1, and EBF1 are frequently mutated in B cell acute lymphoblastic leukemia (B-ALL). We demonstrate that compound…”
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Receptor for hyaluronan‐mediated motility (RHAMM) defines an invasive niche associated with tumor progression and predicts poor outcomes in breast cancer patients by Tarullo, Sarah E, He, Yuyu, Daughters, Claire, Knutson, Todd P, Henzler, Christine M, Price, Matthew A, Shanley, Ryan, Witschen, Patrice, Tolg, Cornelia, Kaspar, Rachael E, Hallstrom, Caroline, Gittsovich, Lyubov, Sulciner, Megan L, Zhang, Xihong, Forster, Colleen L, Lange, Carol A, Shats, Oleg, Desler, Michelle, Cowan, Kenneth H, Yee, Douglas, Schwertfeger, Kathryn L, Turley, Eva A, McCarthy, James B, Nelson, Andrew C

“…Breast cancer invasion and metastasis result from a complex interplay between tumor cells and the tumor microenvironment (TME). Key oncogenic changes in the…”
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NK Cell and Monocyte Dysfunction in Multisystem Inflammatory Syndrome in Children by Dick, Jenna K, Sangala, Jules A, Krishna, Venkatramana D, Khaimraj, Aaron, Hamel, Lydia, Erickson, Spencer M, Hicks, Dustin, Soigner, Yvette, Covill, Laura E, Johnson, Alexander K, Ehrhardt, Michael J, Ernste, Keenan, Brodin, Petter, Koup, Richard A, Khaitan, Alka, Baehr, Carly, Thielen, Beth K, Henzler, Christine M, Skipper, Caleb, Miller, Jeffrey S, Bryceson, Yenan T, Wu, Jianming, John, Chandy C, Panoskaltsis-Mortari, Angela, Orioles, Alberto, Steiner, Marie E, Cheeran, Maxim C J, Pravetoni, Marco, Hart, Geoffrey T

“…Multisystem inflammatory syndrome in children (MIS-C) is a severe complication of SARS-CoV-2 infection characterized by multiorgan involvement and…”
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Deep annotation of mouse iso-miR and iso-moR variation by Zhou, Hongjun, Arcila, Mary Luz, Li, Zhonghan, Lee, Eun Joo, Henzler, Christine, Liu, Jingya, Rana, Tariq M, Kosik, Kenneth S

“…With a dataset of more than 600 million small RNAs deeply sequenced from mouse hippocampal and staged sets of mouse cells that underwent reprogramming to…”
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Reduction of protein kinase A-mediated phosphorylation of ATXN1-S776 in Purkinje cells delays onset of Ataxia in a SCA1 mouse model by Pérez Ortiz, Judit M., Mollema, Nissa, Toker, Nicholas, Adamski, Carolyn J., O'Callaghan, Brennon, Duvick, Lisa, Friedrich, Jillian, Walters, Michael A., Strasser, Jessica, Hawkinson, Jon E., Zoghbi, Huda Y., Henzler, Christine, Orr, Harry T., Lagalwar, Sarita

“…Spinocerebellar ataxia type 1 (SCA1) is a polyglutamine (polyQ) repeat neurodegenerative disease in which a primary site of pathogenesis are cerebellar…”
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Optimal detection of clinically relevant mutations in colorectal carcinoma: sample pooling overcomes intra-tumoral heterogeneity by Nelson, Andrew C, Boone, Jamie, Cartwright, David, Thyagarajan, Bharat, Kincaid, Robyn, Lambert, Aaron P, Karnuth, Kylene, Henzler, Christine, Yohe, Sophia

“…Intra-tumoral genomic heterogeneity is a well-established biologic property of human malignancies with emerging roles in cancer progression and therapy…”
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