Search Results - "Henzi, Thomas"
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The Parvalbumin Hypothesis of Autism Spectrum Disorder
Published in Frontiers in cellular neuroscience (18-12-2020)“…The prevalence of autism spectrum disorder (ASD)-a type of neurodevelopmental disorder-is increasing and is around 2% in North America, Asia, and Europe…”
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Antagonistic Regulation of Parvalbumin Expression and Mitochondrial Calcium Handling Capacity in Renal Epithelial Cells
Published in PloS one (05-11-2015)“…Parvalbumin (PV) is a cytosolic Ca2+-binding protein acting as a slow-onset Ca2+ buffer modulating the shape of Ca2+ transients in fast-twitch muscles and a…”
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How asbestos drives the tissue towards tumors: YAP activation, macrophage and mesothelial precursor recruitment, RNA editing, and somatic mutations
Published in Oncogene (01-05-2018)“…Chronic exposure to intraperitoneal asbestos triggered a marked response in the mesothelium well before tumor development. Macrophages, mesothelial precursor…”
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Forchlorfenuron and Novel Analogs Cause Cytotoxic Effects in Untreated and Cisplatin-Resistant Malignant Mesothelioma-Derived Cells
Published in International journal of molecular sciences (02-04-2022)“…Malignant mesothelioma (MM) is a currently incurable, aggressive cancer derived from mesothelial cells, most often resulting from asbestos exposure. The…”
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Septins in Infections: Focus on Viruses
Published in Pathogens (Basel) (02-03-2021)“…Human septins comprise a family of 13 genes that encode conserved GTP-binding proteins. They form nonpolar complexes, which assemble into higher-order…”
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Menthol evokes Ca2+ signals and induces oxidative stress independently of the presence of TRPM8 (menthol) receptor in cancer cells
Published in Redox biology (01-04-2018)“…Menthol is a naturally occurring monoterpene alcohol possessing remarkable biological properties including antipruritic, analgesic, antiseptic,…”
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Absence of calretinin protein expression in malignant mesotheliomas from asbestos-exposed NF2 +/- mice and mouse mesothelioma cell lines from various mouse strains
Published in Biomarker research (06-06-2018)“…Calretinin is the most widespread positive marker for the immunohistochemical identification of malignant mesothelioma (MM) and was proposed to serve as a…”
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Endogenous TRPV1 stimulation leads to the activation of the inositol phospholipid pathway necessary for sustained Ca2+ oscillations
Published in Biochimica et biophysica acta. Molecular cell research (01-12-2016)“…Sensory neuron subpopulations as well as breast and prostate cancer cells express functional transient receptor potential vanilloid type 1 (TRPV1) ion…”
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Biological noise and positional effects influence cell stemness
Published in The Journal of biological chemistry (06-04-2018)“…Biological (or cellular) noise is the random quantitative variability of proteins and other molecules in individual, genetically identical cells. As the result…”
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The Complex Crosstalk between Parvalbumin and Mitochondria Regulation through Changes in Mitochondrial Dynamics
Published in Biophysical journal (15-02-2019)Get full text
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Parvalbumin alters mitochondrial dynamics and affects cell morphology
Published in Cellular and molecular life sciences : CMLS (01-12-2018)“…The Ca 2+ -binding protein parvalbumin (PV) and mitochondria play important roles in Ca 2+ signaling, buffering and sequestration. Antagonistic regulation of…”
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The phytohormone forchlorfenuron decreases viability and proliferation of malignant mesothelioma cells in vitro and in vivo
Published in Oncotarget (10-12-2019)“…Malignant mesothelioma (MM) is one of the most aggressive cancer types with a patient's life expectancy of typically less than one year upon diagnosis. The…”
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Antagonistic Regulation of Parvalbumin Expression and Mitochondrial Calcium Handling Capacity in Renal Epithelial Cells: e0142005
Published in PloS one (01-11-2015)“…Parvalbumin (PV) is a cytosolic Ca2+-binding protein acting as a slow-onset Ca2+ buffer modulating the shape of Ca2+ transients in fast-twitch muscles and a…”
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Amyloid pathology‐produced unexpected modifications of calcium homeostasis in hippocampal subicular dendrites
Published in Alzheimer's & dementia (01-02-2020)“…Introduction Alzheimer's disease (AD) is linked to neuronal calcium dyshomeostasis, which is associated with network hyperexcitability. Decreased expression of…”
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A bipartite butyrate-responsive element in the human calretinin (CALB2) promoter acts as a repressor in colon carcinoma cells but not in mesothelioma cells
Published in Journal of cellular biochemistry (15-02-2010)“…The short‐chain fatty acid butyrate plays an essential role in colonic mucosa homeostasis through the capacity to block the cell cycle, regulate…”
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Endogenous TRPV1 stimulation leads to the activation of the inositol phospholipid pathway necessary for sustained Ca 2+ oscillations
Published in Biochimica et biophysica acta (01-12-2016)“…Sensory neuron subpopulations as well as breast and prostate cancer cells express functional transient receptor potential vanilloid type 1 (TRPV1) ion…”
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Calretinin Regulates Ca2+-dependent Inactivation and Facilitation of Cav2.1 Ca2+ Channels through a Direct Interaction with the α12.1 Subunit
Published in The Journal of biological chemistry (16-11-2012)“…Voltage-gated Cav2.1 Ca2+ channels undergo dual modulation by Ca2+, Ca2+-dependent inactivation (CDI), and Ca2+-dependent facilitation (CDF), which can…”
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SV40-Induced Expression of Calretinin Protects Mesothelial Cells from Asbestos Cytotoxicity and May Be a Key Factor Contributing to Mesothelioma Pathogenesis
Published in The American journal of pathology (01-06-2009)“…The calcium-binding protein calretinin has emerged as a useful marker for the identification of mesotheliomas of the epithelioid and mixed types, but its…”
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Menthol evokes Ca 2+ signals and induces oxidative stress independently of the presence of TRPM8 (menthol) receptor in cancer cells
Published in Redox biology (01-04-2018)“…Menthol is a naturally occurring monoterpene alcohol possessing remarkable biological properties including antipruritic, analgesic, antiseptic,…”
Get full text
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