Search Results - "Hentze, M."

Balancing Acts: Molecular Control of Mammalian Iron Metabolism by Hentze, Matthias W, Muckenthaler, Martina U, Andrews, Nancy C

“…Iron is ubiquitous in the environment and in biology. The study of iron biology focuses on physiology and homeostasis—understanding how cells and organisms…”
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Molecular Control of Vertebrate Iron Metabolism: mRNA-Based Regulatory Circuits Operated by Iron, Nitric Oxide, and Oxidative Stress by Hentze, Matthias W., Kühn, Lukas C.

“…As an essential nutrient and a potential toxin, iron poses an exquisite regulatory problem in biology and medicine. At the cellular level, the basic molecular…”
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eIF4G : A multipurpose ribosome adapter? by HENTZE, M. W

“…Messenger RNAs are translated into protein—a complex enterprise. Now, in work from a number of laboratories, one small adapter protein is shown to be a central…”
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Abnormal body iron distribution and erythropoiesis in a novel mouse model with inducible gain of iron regulatory protein (IRP)-1 function by Casarrubea, D., Viatte, L., Hallas, T., Vasanthakumar, A., Eisenstein, R. S., Schümann, K., Hentze, M. W., Galy, B.

“…Disorders of iron metabolism account for some of the most common human diseases. Cellular iron homeostasis is maintained by iron regulatory proteins (IRP)-1…”
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Dual function of the messenger RNA cap structure in poly(A)-tail-promoted translation in yeast by Hentze, Matthias W, Preiss, Thomas

“…The messenger RNA 3′ poly(A) tail critically affects the initiation and control of translation in eukaryotes. By analogy to elements involved in transcription…”
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Picornavirus IRESes and the poly(A) tail jointly promote cap-independent translation in a mammalian cell-free system by BERGAMINI, GIOVANNA, PREISS, THOMAS, HENTZE, MATTHIAS W.

“…In eukaryotic cells, efficient translation of most cellular mRNAs requires the synergistic interplay between the m7GpppN cap structure and the poly(A) tail…”
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From cis-regulatory elements to complex RNPs and back by Gebauer, Fátima, Preiss, Thomas, Hentze, Matthias W

“…Messenger RNAs (mRNAs), the templates for translation, have evolved to harbor abundant cis-acting sequences that affect their posttranscriptional fates. These…”
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Iron regulates nitric oxide synthase activity by controlling nuclear transcription by WEISS, G, WERNER-FELMAYER, G, WERNER, E. R, GRÜNEWALD, K, WACHTER, H, HENTZE, M. W

“…Recently, it was reported that nitric oxide (NO) directly controls intracellular iron metabolism by activating iron regulatory protein (IRP), a cytoplasmic…”
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SIREs: searching for iron-responsive elements by Campillos, Monica, Cases, Ildefonso, Hentze, Matthias W, Sanchez, Mayka

“…The iron regulatory protein/iron-responsive element regulatory system plays a crucial role in the post-transcriptional regulation of gene expression and its…”
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A Perfect Message: RNA Surveillance and Nonsense-Mediated Decay by Hentze, Matthias W, Kulozik, Andreas E

“…The robustness of biological systems depends on the function of proofreading mechanisms against operating errors. Studies in yeast and of human genetic…”
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Starting the protein synthesis machine: eukaryotic translation initiation by Preiss, Thomas, W. Hentze, Matthias

“…The final assembly of the protein synthesis machinery occurs during translation initiation. This delicate process involves both ends of eukaryotic messenger…”
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A Novel Duodenal Iron-Regulated Transporter, IREG1, Implicated in the Basolateral Transfer of Iron to the Circulation by McKie, Andrew T, Marciani, Paola, Rolfs, Andreas, Brennan, Karen, Wehr, Kristina, Barrow, Dalna, Miret, Silvia, Bomford, Adrian, Peters, Timothy J, Farzaneh, Farzin, Hediger, Matthias A, Hentze, Matthias W, Simpson, Robert J

“…Iron absorption by the duodenal mucosa is initiated by uptake of ferrous Fe(II) iron across the brush border membrane and culminates in transfer of the metal…”
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Homodirectional changes in transcriptome composition and mRNA translation induced by rapamycin and heat shock by Hentze, Matthias W, Preiss, Thomas, Baron-Benhamou, Julie, Ansorge, Wilhelm

“…Transcription and mRNA turnover determine the quantitative composition of the cellular transcriptome. The transcriptome in turn serves as a template for the…”
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Pathways for the regulation of macrophage iron metabolism by the anti- inflammatory cytokines IL-4 and IL-13 by Weiss, G, Bogdan, C, Hentze, MW

“…Macrophage effector functions are influenced by their iron status and by shifts in the balance between type 1 Th1 and Th2 cells. To elucidate the influence of…”
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Y14 and hUpf3b Form an NMD-Activating Complex by Gehring, Niels H., Neu-Yilik, Gabriele, Schell, Thomas, Hentze, Matthias W., Kulozik, Andreas E.

“…Messenger RNAs with premature translation termination codons (PTCs) are degraded by nonsense-mediated mRNA decay (NMD). In mammals, PTCs are discriminated from…”
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Translational regulation of mammalian and Drosophila citric acid cycle enzymes via iron-responsive elements by Gray, Nicola K., Pantopoulos, Kostas, Dandekar, Thomas, Ackrell, Brian A. C., Hentze, Matthias W.

“…The posttranscriptional control of iron uptake, storage, and utilization by iron-responsive elements (IREs) and iron regulatory proteins (IRPs) provides a…”
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Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis by Hentze, Matthias W, Custodio, Ángel O, Miñana, Belén, Andrews, Nancy C, Roy, Cindy N, Muckenthaler, Martina, deGraaf, Jos, Montross, Lynne K

“…Individuals with hereditary hemochromatosis suffer from systemic iron overload due to duodenal hyperabsorption. Most cases arise from a founder mutation in HFE…”
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Nitric oxide and oxidative stress (H2O2) control mammalian iron metabolism by different pathways by Pantopoulos, Kostas, Weiss, Günter, Hentze, Matthias W.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Translational regulation via iron‐responsive elements by the nitric oxide/NO‐synthase pathway by Weiss, G., Goossen, B., Doppler, W., Fuchs, D., Pantopoulos, K., Werner‐Felmayer, G., Wachter, H., Hentze, M.W.

“…Nitric oxide (NO) produced from L‐arginine by NO synthases (NOS) is a transmitter known to be involved in diverse biological processes, including…”
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Iron regulatory protein prevents binding of the 43S translation pre‐initiation complex to ferritin and eALAS mRNAs by Gray, N.K., Hentze, M.W.

“…Translation of ferritin and erythroid 5‐aminolevulinate synthase (eALAS) mRNAs is regulated by iron via mRNA‐protein interactions between iron‐responsive…”
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