Search Results - "Henthorn, Thomas K."

Editorial: Ketamine for treatment of acute and chronic pain: The relationship of mechanism and exposure to therapeutic outcome by Dahan, Albert, Henthorn, Thomas K.

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Reversal for Respiratory Depression: Let's Take a Breath by Henthorn, Thomas K

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A Survey of Propofol Abuse in Academic Anesthesia Programs by Wischmeyer, Paul E., Johnson, Bradley R., Wilson, Joel E., Dingmann, Colleen, Bachman, Heidi M., Roller, Evan, Tran, Zung Vu, Henthorn, Thomas K.

“…Although propofol has not traditionally been considered a drug of abuse, subanesthetic doses may have an abuse potential. We used this survey to assess…”
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Using the time of maximum effect site concentration to combine pharmacokinetics and pharmacodynamics by MINTO, Charles F, SCHNIDER, Thomas W, GREGG, Keith M, HENTHORN, Thomas K, SHAFER, Steven L

“…To simulate the time course of drug effect, it is sometimes necessary to combine the pharmacodynamic parameters from an integrated…”
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Ketamine Psychedelic and Antinociceptive Effects Are Connected by Olofsen, Erik, Kamp, Jasper, Henthorn, Thomas K., van Velzen, Monique, Niesters, Marieke, Sarton, Elise, Dahan, Albert

“…Ketamine produces potent analgesia combined with psychedelic effects. It has been suggested that these two effects are associated and possibly that analgesia…”
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Ketamine Pharmacodynamics Entangled: Reply by Dahan, Albert, Olofsen, Erik, Henthorn, Thomas K., van Velzen, Monique, Niesters, Marieke

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Competitive Substrates for P-Glycoprotein and Organic Anion Protein Transporters Differentially Reduce Blood Organ Transport of Fentanyl and Loperamide: Pharmacokinetics and Pharmacodynamics in Sprague-Dawley Rats by Elkiweri, Iman A., Zhang, Yan Ling, Christians, Uwe, Ng, Ka-Yun, Tissot van Patot, Martha C., Henthorn, Thomas K.

“…Drug transport proteins may be instrumental in controlling the concentration of fentanyl at mu receptors in the brain and may provide potential therapeutic…”
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Where’s the Beef?: How Much Can We Skimp on Pharmacokinetic–Pharmacodynamic Data? by Henthorn, Thomas K, Olofsen, Erik

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Investigation of Two Dosing Schedules of Vandetanib (ZD6474), an Inhibitor of Vascular Endothelial Growth Factor Receptor and Epidermal Growth Factor Receptor Signaling, in Combination with Irinotecan in a Human Colon Cancer Xenograft Model by TROIANI, Teresa, SERKOVA, Natalie J, GUSTAFSON, Daniel L, HENTHORN, Thomas K, LOCKERBIE, Owen, MERZ, Andrea, LONG, Michael, MORROW, Mark, CIARDIELLO, Fortunato, ECKHARDT, S. Gail

“…Purpose: This in vivo study was designed to determine the optimal doses and schedules of vandetanib, a dual epidermal growth factor receptor (EGFR)-vascular…”
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Detection of Cannabinoids by LC–MS-MS and ELISA in Breast Milk by Sempio, Cristina, Wymore, Erica, Palmer, Claire, Bunik, Maya, Henthorn, Thomas K, Christians, Uwe, Klawitter, Jost

“…Abstract Cannabis is the most commonly used drug of abuse in pregnancy and after delivery. However, little is known regarding the disposition of cannabinoids…”
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Elimination Clearance of Dexmedetomidine: Cross-examining What the Data Say by Henthorn, Thomas K., Krejcie, Tom C., Avram, Michael J.

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Dose Estimation Utility in a Population Pharmacokinetic Analysis of Inhaled Δ9-Tetrahydrocannabinol Cannabis Market Products in Occasional and Daily Users by Henthorn, Thomas K, Wang, George S, Dooley, Greg, Brooks-Russell, Ashley, Wrobel, Julia, Limbacher, Sarah, Kosnett, Michael

“…Unusually high variability in blood Δ9-tetrahydrocannabinol (THC) concentrations have been observed in subjects inhaling similar cannabis products over similar…”
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Population Pharmacokinetics of Single Bolus Dose Fentanyl in Obese Children by Okada, Carol R, Henthorn, Thomas K, Zuk, Jeannie, Sempio, Cristina, Roosevelt, Genie, Ruiz, Amanda G, Cohen, Mindy N, Chatterjee, Debnath, Galinkin, Jeffrey L

“…Childhood obesity is a significant problem. Obesity may alter the pharmacokinetics (PKs) of medications. Fentanyl is commonly used for procedural sedation, but…”
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Ketamine Pharmacokinetics by Kamp, Jasper, Olofsen, Erik, Henthorn, Thomas K, van Velzen, Monique, Niesters, Marieke, Dahan, Albert

“…Several models describing the pharmacokinetics of ketamine are published with differences in model structure and complexity. A systematic review of the…”
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Blood cannabinoid molar metabolite ratios are superior to blood THC as an indicator of recent cannabis smoking by Kosnett, Michael J., Ma, Ming, Dooley, Gregory, Wang, George Sam, Friedman, Kyle, Brown, Timothy, Henthorn, Thomas K., Brooks-Russell, Ashley

“…Cannabis use is a growing concern in transportation and workplace incidents. Because Δ9-tetrahydrocannabinol is detectable after acute psychoactive effects…”
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μ-Opioid Receptor Agonists: Do They Have Utility in the Treatment of Acute Pain? by Henthorn, Thomas K, Mikulich-Gilbertson, Susan K

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Lidocaine Intraoperative Infusion Pharmacokinetics during Partial Hepatectomy for Living Liver Donation by Crouch, Cara E., Wilkey, Barbara J., Hendrickse, Adrian, Kaizer, Alexander M., Schniedewind, Björn, Christians, Uwe, Henthorn, Thomas K., Fernandez-Bustamante, Ana

“…Postoperative pain associated with open partial hepatectomy can be intense and persistent. The multimodal approach used to lessen this problem includes an…”
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Opioid-induced Ventilatory Depression in Sleep Apnea: Reply by Doufas, Anthony G, Shafer, Steven L, Henthorn, Thomas K

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Multicenter Population Pharmacokinetics of Fentanyl in Neonatal Surgical Patients Using Dried Blood Spot Specimen Collection Demonstrates Maturation of Elimination Clearance by Rzasa Lynn, Rachael S, Henthorn, Thomas K, Zuk, Jeannie, Hammer, Gregory B, Drover, David R, Levy, Richard J, Maxwell, Lynne G, Sadhasivam, Senthilkumar, Suresh, Santhanam, Galinkin, Jeffrey L

“…Fentanyl is widely used for analgesia and sedation in neonates, but pharmacokinetic (PK) analysis in this population has been limited by the relatively large…”
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The minor cannabinoid cannabigerol (CBG) is a highly specific blood biomarker of recent cannabis smoking by Rague, John M., Ma, Ming, Dooley, Gregory, Wang, George Sam, Friedman, Kyle, Henthorn, Thomas K., Brooks-Russell, Ashley, Kosnett, Michael J.

“…The determination of recent cannabis use is of forensic interest in the investigation of automotive crashes, workplace incidents and other mishaps. Because…”
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