Search Results - "Henthorn, Nicholas T."

Geometrical structures for radiation biology research as implemented in the TOPAS-nBio toolkit by McNamara, Aimee L, Ramos-Méndez, José, Perl, Joseph, Held, Kathryn, Dominguez, Naoki, Moreno, Eduardo, Henthorn, Nicholas T, Kirkby, Karen J, Meylan, Sylvain, Villagrasa, Carmen, Incerti, Sebastien, Faddegon, Bruce, Paganetti, Harald, Schuemann, Jan

“…Computational simulations, such as Monte Carlo track structure simulations, offer a powerful tool for quantitatively investigating radiation interactions…”
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VHEE FLASH sparing effect measured at CLEAR, CERN with DNA damage of pBR322 plasmid as a biological endpoint by Wanstall, Hannah C., Korysko, Pierre, Farabolini, Wilfred, Corsini, Roberto, Bateman, Joseph J., Rieker, Vilde, Hemming, Abigail, Henthorn, Nicholas T., Merchant, Michael J., Santina, Elham, Chadwick, Amy L., Robertson, Cameron, Malyzhenkov, Alexander, Jones, Roger M.

“…Ultra-high dose rate (UHDR) irradiation has been shown to have a sparing effect on healthy tissue, an effect known as ‘FLASH’. This effect has been studied…”
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First in vitro measurement of VHEE relative biological effectiveness (RBE) in lung and prostate cancer cells using the ARES linac at DESY by Wanstall, Hannah C., Burkart, Florian, Dinter, Hannes, Kellermeier, Max, Kuropka, Willi, Mayet, Frank, Vinatier, Thomas, Santina, Elham, Chadwick, Amy L., Merchant, Michael J., Henthorn, Nicholas T., Köpke, Michael, Stacey, Blae, Jaster-Merz, Sonja, Jones, Roger M.

“…Very high energy electrons (VHEE) are a potential candidate for radiotherapy applications. This includes tumours in inhomogeneous regions such as lung and…”
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Hi-C implementation of genome structure for in silico models of radiation-induced DNA damage by Ingram, Samuel P, Henthorn, Nicholas T, Warmenhoven, John W, Kirkby, Norman F, Mackay, Ranald I, Kirkby, Karen J, Merchant, Michael J

“…Developments in the genome organisation field has resulted in the recent methodology to infer spatial conformations of the genome directly from experimentally…”
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Modelling Heterogeneous Anomalous Dynamics of Radiation-Induced Double-Strand Breaks in DNA during Non-Homologous End-Joining Pathway by Korabel, Nickolay, Warmenhoven, John W, Henthorn, Nicholas T, Ingram, Samuel, Fedotov, Sergei, Heaven, Charlotte J, Kirkby, Karen J, Taylor, Michael J, Merchant, Michael J

“…The process of end-joining during nonhomologous repair of DNA double-strand breaks (DSBs) after radiation damage is considered. Experimental evidence has…”
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A computational approach to quantifying miscounting of radiation-induced double-strand break immunofluorescent foci by Ingram, Samuel P., Warmenhoven, John-William, Henthorn, Nicholas T., Chadiwck, Amy L., Santina, Elham E., McMahon, Stephen J., Schuemann, Jan, Kirkby, Norman F., Mackay, Ranald I., Kirkby, Karen J., Merchant, Michael J.

“…Immunofluorescent tagging of DNA double-strand break (DSB) markers, such as γ -H2AX and other DSB repair proteins, are powerful tools in understanding…”
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Cellular Response to Proton Irradiation: A Simulation Study with TOPAS-nBio by Zhu, Hongyu, McNamara, Aimee L., McMahon, Stephen J., Ramos-Mendez, Jose, Henthorn, Nicholas T., Faddegon, Bruce, Held, Kathryn D., Perl, Joseph, Li, Junli, Paganetti, Harald, Schuemann, Jan

“…The cellular response to ionizing radiation continues to be of significant research interest in cancer radiotherapy, and DNA is recognized as the critical…”
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Modelling direct DNA damage for gold nanoparticle enhanced proton therapy by Sotiropoulos, Marios, Henthorn, Nicholas T, Warmenhoven, John W, Mackay, Ranald I, Kirkby, Karen J, Merchant, Michael J

“…Gold nanoparticles have been proven as potential radiosensitizer when combined with protons. Initially the radiosensitization effect was attributed to the…”
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Proposing a Clinical Model for RBE Based on Proton Track-End Counts by Henthorn, Nicholas T., Gardner, Lydia L., Aitkenhead, Adam H., Rowland, Benjamin C., Shin, Jungwook, Smith, Edward A.K., Merchant, Michael J., Mackay, Ranald I., Kirkby, Karen J., Chaudhary, Pankaj, Prise, Kevin M., McMahon, Stephen J., Underwood, Tracy S.A.

“…In proton therapy, the clinical application of linear energy transfer (LET) optimization remains contentious, in part because of challenges associated with the…”
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Effects of Differing Underlying Assumptions in In Silico Models on Predictions of DNA Damage and Repair by Warmenhoven, John W., Henthorn, Nicholas T., McNamara, Aimee L., Ingram, Samuel P., Merchant, Michael J., Kirkby, Karen J., Schuemann, Jan, Paganetti, Harald, Prise, Kevin M., McMahon, Stephen J.

“…The induction and repair of DNA double-strand breaks (DSBs) are critical factors in the treatment of cancer by radiotherapy. To investigate the relationship…”
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Insights into the non-homologous end joining pathway and double strand break end mobility provided by mechanistic in silico modelling by Warmenhoven, John W., Henthorn, Nicholas T., Ingram, Samuel P., Chadwick, Amy L., Sotiropoulos, Marios, Korabel, Nickolay, Fedotov, Sergei, Mackay, Ranald I., Kirkby, Karen J., Merchant, Michael J.

“…•c-NHEJ modelled as two stage synapsis, with initial stage prone to dissociation.•Initial stage modelled as dissociating after autophosphorylation of…”
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The suitability of micronuclei as markers of relative biological effect by Heaven, Charlotte J, Wanstall, Hannah C, Henthorn, Nicholas T, Warmenhoven, John-William, Ingram, Samuel P, Chadwick, Amy L, Santina, Elham, Honeychurch, Jamie, Schmidt, Christine K, Kirkby, Karen J, Kirkby, Norman F, Burnet, Neil G, Merchant, Michael J

“…Abstract Micronucleus (MN) formation is routinely used as a biodosimeter for radiation exposures and has historically been used as a measure of DNA damage in…”
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Emulating the Delivery of Sawtooth Proton Arc Therapy Plans on a Cyclotron-Based Proton Beam Therapy System by Burford-Eyre, Samuel, Aitkenhead, Adam, Aylward, Jack D, Henthorn, Nicholas T, Ingram, Samuel P, Mackay, Ranald, Manger, Samuel, Merchant, Michael J, Sitch, Peter, Warmenhoven, John-William, Appleby, Robert B

“…: To evaluate and compare the deliverability of 'sawtooth' proton arc therapy (PAT) plans relative to static intensity modulated proton therapy (IMPT) at a…”
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Quantification of damage to plasmid DNA from 35 MeV electrons, 228 MeV protons and 300 kVp X-rays in varying hydroxyl radical scavenging environments by Wanstall, Hannah C, Henthorn, Nicholas T, Jones, James, Santina, Elham, Chadwick, Amy L, Angal-Kalinin, Deepa, Morris, Geoffrey, Warmenhoven, John-William, Smith, Rob, Mathisen, Storm, Merchant, Michael J, Jones, Roger M

“…Abstract The pBR322 plasmid DNA was irradiated with 35 MeV electrons, 228 MeV protons and 300 kVp X-rays to quantify DNA damage and make comparisons of DNA…”
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Estimating the percentage of patients who might benefit from proton beam therapy instead of X-ray radiotherapy by Burnet, Neil G, Mee, Thomas, Gaito, Simona, Kirkby, Norman F, Aitkenhead, Adam H, Anandadas, Carmel N, Aznar, Marianne C, Barraclough, Lisa H, Borst, Gerben, Charlwood, Frances C, Clarke, Matthew, Colaco, Rovel J, Crellin, Adrian M, Defourney, Noemie N, Hague, Christina J, Harris, Margaret, Henthorn, Nicholas T, Hopkins, Kirsten I, Hwang, E, Ingram, Sam P, Kirkby, Karen J, Lee, Lip W, Lines, David, Lingard, Zoe, Lowe, Matthew, Mackay, Ranald I, McBain, Catherine A, Merchant, Michael J, Noble, David J, Pan, Shermaine, Price, James M, Radhakrishna, Ganesh, Reboredo-Gil, David, Salem, Ahmed, Sashidharan, Srijith, Sitch, Peter, Smith, Ed, Smith, Edward Ak, Taylor, Michael J, Thomson, David J, Thorp, Nicola J, Underwood, Tracy Sa, Warmenhoven, John W, Wylie, James P, Whitfield, Gillian

“…High-energy Proton Beam Therapy (PBT) commenced in England in 2018 and NHS England commissions PBT for 1.5% of patients receiving radical radiotherapy. We…”
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A parameter sensitivity study for simulating DNA damage after proton irradiation using TOPAS-nBio by Zhu, Hongyu, McNamara, Aimee L, Ramos-Mendez, Jose, McMahon, Stephen J, Henthorn, Nicholas T, Faddegon, Bruce, Held, Kathryn D, Perl, Joseph, Li, Junli, Paganetti, Harald, Schuemann, Jan

“…Monte Carlo (MC) track structure simulation tools are commonly used for predicting radiation induced DNA damage by modeling the physical and chemical reactions…”
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Mapping the Future of Particle Radiobiology in Europe: The INSPIRE Project by Henthorn, Nicholas T., Sokol, Olga, Durante, Marco, De Marzi, Ludovic, Pouzoulet, Frederic, Miszczyk, Justyna, Olko, Pawel, Brandenburg, Sytze, van Goethem, Marc Jan, Barazzuol, Lara, Tambas, Makbule, Langendijk, Johannes A., Davídková, Marie, Vondráĉek, Vladimír, Bodenstein, Elisabeth, Pawelke, Joerg, Lomax, Antony J., Weber, Damien C., Dasu, Alexandru, Stenerlöw, Bo, Poulsen, Per R., Sørensen, Brita S., Grau, Cai, Sitarz, Mateusz K., Heuskin, Anne-Catherine, Lucas, Stephane, Warmenhoven, John W., Merchant, Michael J., Mackay, Ran I., Kirkby, Karen J.

“…Particle therapy is a growing cancer treatment modality worldwide. However, there still remains a number of unanswered questions considering differences in the…”
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