Search Results - "Hensel, Niko"

The Need for SMN-Independent Treatments of Spinal Muscular Atrophy (SMA) to Complement SMN-Enhancing Drugs by Hensel, Niko, Kubinski, Sabrina, Claus, Peter

“…Spinal Muscular Atrophy (SMA) is monogenic motoneuron disease caused by low levels of the Survival of Motoneuron protein (SMN). Recently, two different drugs…”
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ERK and ROCK functionally interact in a signaling network that is compensationally upregulated in Spinal Muscular Atrophy by Hensel, Niko, Baskal, Svetlana, Walter, Lisa Marie, Brinkmann, Hella, Gernert, Manuela, Claus, Peter

“…Spinal Muscular Atrophy (SMA) is a motoneuron disease caused by low levels of functional survival of motoneuron protein (SMN). Molecular disease mechanisms…”
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Fibroblast growth factor 23 signaling in hippocampal cells: impact on neuronal morphology and synaptic density by Hensel, Niko, Schön, Anne, Konen, Timo, Lübben, Verena, Förthmann, Benjamin, Baron, Olga, Grothe, Claudia, Leifheit‐Nestler, Maren, Claus, Peter, Haffner, Dieter

“…Endocrine fibroblast growth factor 23 (FGF23) is predominantly secreted by osteocytes and facilitates renal phosphate excretion. However, FGF23 is also present…”
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The spinal muscular atrophy disease protein SMN is linked to the rho-kinase pathway via profilin by Nölle, Anna, Zeug, Andre, van Bergeijk, Jeroen, Tönges, Lars, Gerhard, Ralf, Brinkmann, Hella, Al Rayes, Sarah, Hensel, Niko, Schill, Yvonne, Apkhazava, David, Jablonka, Sibylle, O'mer, Jana, Kumar Srivastav, Ratnesh, Baasner, Anne, Lingor, Paul, Wirth, Brunhilde, Ponimaskin, Evgeni, Niedenthal, Rainer, Grothe, Claudia, Claus, Peter

“…Spinal muscular atrophy (SMA), a frequent neurodegenerative disease, is caused by reduced levels of functional survival of motoneuron (SMN) protein. SMN is…”
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Suppression of the necroptotic cell death pathways improves survival in Smn2B/− mice by Chehade, Lucia, Deguise, Marc-Olivier, De Repentigny, Yves, Yaworski, Rebecca, Beauvais, Ariane, Gagnon, Sabrina, Hensel, Niko, Kothary, Rashmi

“…Spinal muscular atrophy (SMA) is a monogenic neuromuscular disease caused by low levels of the Survival Motor Neuron (SMN) protein. Motor neuron degeneration…”
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Therapeutic potential of mesenchymal stromal cells and MSC conditioned medium in Amyotrophic Lateral Sclerosis (ALS)--in vitro evidence from primary motor neuron cultures, NSC-34 cells, astrocytes and microglia by Sun, Hui, Bénardais, Karelle, Stanslowsky, Nancy, Thau-Habermann, Nadine, Hensel, Niko, Huang, Dongya, Claus, Peter, Dengler, Reinhard, Stangel, Martin, Petri, Susanne

“…Administration of mesenchymal stromal cells (MSC) improves functional outcome in the SOD1G93A mouse model of the degenerative motor neuron disorder amyotrophic…”
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The Proteome and Secretome of Cortical Brain Cells Infected With Herpes Simplex Virus by Hensel, Niko, Raker, Verena, Förthmann, Benjamin, Buch, Anna, Sodeik, Beate, Pich, Andreas, Claus, Peter

“…Infections of the brain with herpes simplex virus type 1 (HSV-1) cause life-threatening Herpes simplex encephalitis (HSE) characterized by viral replication in…”
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Analysis of the fibroblast growth factor system reveals alterations in a mouse model of spinal muscular atrophy by Hensel, Niko, Ratzka, Andreas, Brinkmann, Hella, Klimaschewski, Lars, Grothe, Claudia, Claus, Peter

“…The monogenetic disease Spinal Muscular Atrophy (SMA) is characterized by a progressive loss of motoneurons leading to muscle weakness and atrophy due to…”
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Bilateral crosstalk of rho- and extracellular-signal-regulated-kinase (ERK) pathways is confined to an unidirectional mode in spinal muscular atrophy (SMA) by Hensel, Niko, Stockbrügger, Inga, Rademacher, Sebastian, Broughton, Natasha, Brinkmann, Hella, Grothe, Claudia, Claus, Peter

“…Rho-kinase (ROCK) as well as extracellular signal regulated kinase (ERK) control actin cytoskeletal organization thereby regulating dynamic changes of cellular…”
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HSV-1 triggers paracrine fibroblast growth factor response from cortical brain cells via immediate-early protein ICP0 by Hensel, Niko, Raker, Verena, Förthmann, Benjamin, Detering, Nora Tula, Kubinski, Sabrina, Buch, Anna, Katzilieris-Petras, Georgios, Spanier, Julia, Gudi, Viktoria, Wagenknecht, Sylvia, Kopfnagel, Verena, Werfel, Thomas Andreas, Stangel, Martin, Beineke, Andreas, Kalinke, Ulrich, Paludan, Søren Riis, Sodeik, Beate, Claus, Peter

“…Herpes simplex virus-1 (HSV-1) infections of the central nervous system (CNS) can result in HSV-1 encephalitis (HSE) which is characterized by severe brain…”
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Investigations of Microtubule-associated Protein 2 Gene Expression in Spinal Muscular Atrophy by Bora, Gamze, Sucularli, Ceren, Hensel, Niko, Claus, Peter, Yurter, Hayat Erdem

“…Aim: Spinal muscular atrophy (SMA) is a devastating genetic disease in childhood andff is caused by the absence of functional survival motor neuron (SMN)…”
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The Actin Cytoskeleton in SMA and ALS: How Does It Contribute to Motoneuron Degeneration? by Hensel, Niko, Claus, Peter

“…Amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) are neurodegenerative diseases with overlapping clinical phenotypes based on impaired…”
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The phospho-landscape of the survival of motoneuron protein (SMN) protein: relevance for spinal muscular atrophy (SMA) by Detering, Nora Tula, Schüning, Tobias, Hensel, Niko, Claus, Peter

“…Spinal muscular atrophy (SMA) is caused by low levels of the survival of motoneuron (SMN) Protein leading to preferential degeneration of lower motoneurons in…”
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Resolution of pathogenic R-loops rescues motor neuron degeneration in spinal muscular atrophy by Hensel, Niko, Detering, Nora Tula, Walter, Lisa Marie, Claus, Peter

“…This scientific commentary refers to ‘ZPR1 prevents R-loop accumulation, upregulates SMN2 expression and rescues spinal muscular atrophy’, by Kannan et al…”
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The spinal muscular atrophy gene product regulates actin dynamics by Schüning, Tobias, Zeug, Andre, Strienke, Katharina, Franz, Peter, Tsiavaliaris, Georgios, Hensel, Niko, Viero, Gabriella, Ponimaskin, Evgeni, Claus, Peter

“…Spinal Muscular Atrophy (SMA) is a neuromuscular disease caused by low levels of the Survival of Motoneuron (SMN) protein. SMN interacts with and regulates the…”
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Profilin2a‐phosphorylation as a regulatory mechanism for actin dynamics by Walter, Lisa Marie, Franz, Peter, Lindner, Robert, Tsiavaliaris, Georgios, Hensel, Niko, Claus, Peter

“…Profilin is a major regulator of actin dynamics in multiple specific processes localized in different cellular compartments. This specificity is not only…”
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Microtubule-associated protein 1B dysregulates microtubule dynamics and neuronal mitochondrial transport in spinal muscular atrophy by Bora, Gamze, Hensel, Niko, Rademacher, Sebastian, Koyunoğlu, Dila, Sunguroğlu, Merve, Aksu-Mengeş, Evrim, Balcı-Hayta, Burcu, Claus, Peter, Erdem-Yurter, Hayat

“…Spinal muscular atrophy (SMA) is a devastating childhood disease primarily affecting lower motoneurons in the spinal cord. SMA is caused by the loss of…”
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Altered calcium dynamics and glutamate receptor properties in iPSC-derived motor neurons from ALS patients with C9orf72, FUS, SOD1 or TDP43 mutations by Bursch, Franziska, Kalmbach, Norman, Naujock, Maximilian, Staege, Selma, Eggenschwiler, Reto, Abo-Rady, Masin, Japtok, Julia, Guo, Wenting, Hensel, Niko, Reinhardt, Peter, Boeckers, Tobias M, Cantz, Tobias, Sterneckert, Jared, Van Den Bosch, Ludo, Hermann, Andreas, Petri, Susanne, Wegner, Florian

“…Abstract The fatal neurodegenerative disease amyotrophic lateral sclerosis (ALS) is characterized by a profound loss of motor neurons (MNs). Until now only…”
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Chatting with the neighbors: crosstalk between Rho-kinase (ROCK) and other signaling pathways for treatment of neurological disorders by Hensel, Niko, Rademacher, Sebastian, Claus, Peter

“…ROCK inhibition has been largely applied as a strategy to treat neurodegenerative diseases (NDDs) and promising results have been obtained in the recent years…”
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Central and peripheral delivered AAV9-SMN are both efficient but target different pathomechanisms in a mouse model of spinal muscular atrophy by Reilly, Aoife, Deguise, Marc-Olivier, Beauvais, Ariane, Yaworski, Rebecca, Thebault, Simon, Tessier, Daniel R., Tabard-Cossa, Vincent, Hensel, Niko, Schneider, Bernard L., Kothary, Rashmi

“…Spinal muscular atrophy (SMA) is a neuromuscular disease caused by loss of the SMN1 gene and low SMN protein levels. Although lower motor neurons are a primary…”
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