Search Results - "Hensch, T. K"

Inhibitory threshold for critical-period activation in primary visual cortex by Hensch, Takao K, Fagiolini, Michela

“…Neuronal circuits across several systems display remarkable plasticity to sensory input during postnatal development. Experience-dependent refinements are…”
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Genetic Otx2 mis-localization delays critical period plasticity across brain regions by Lee, H H C, Bernard, C, Ye, Z, Acampora, D, Simeone, A, Prochiantz, A, Di Nardo, A A, Hensch, T K

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Local GABA Circuit Control of Experience-Dependent Plasticity in Developing Visual Cortex by Hensch, Takao K., Fagiolini, Michela, Mataga, Nobuko, Stryker, Michael P., Baekkeskov, Steinunn, Kash, Shera F.

“…Sensory experience in early life shapes the mammalian brain. An impairment in the activity-dependent refinement of functional connections within developing…”
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Otx2 binding to perineuronal nets persistently regulates plasticity in the mature visual cortex by Beurdeley, Marine, Spatazza, Julien, Lee, Henry H C, Sugiyama, Sayaka, Bernard, Clémence, Di Nardo, Ariel A, Hensch, Takao K, Prochiantz, Alain

“…Specific transfer of (orthodenticle homeobox 2) Otx2 homeoprotein into GABAergic interneurons expressing parvalbumin (PV) is necessary and sufficient to open,…”
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Genetic Otx2 mis-localization delays critical period plasticity across brain regions by Lee, H H C, Bernard, C, Ye, Z, Acampora, D, Simeone, A, Prochiantz, A, Di Nardo, A A, Hensch, T K

“…Accumulation of non-cell autonomous Otx2 homeoprotein in postnatal mouse visual cortex (V1) has been implicated in both the onset and closure of critical…”
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Critical period regulation by HENSCH, Takao K

“…Neuronal circuits are shaped by experience during critical periods of early postnatal life. The ability to control the timing, duration, and closure of these…”
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Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines by Luo, Liqun, Hensch, Takao K, Ackerman, Larry, Barbel, Sandra, Jan, Lily Y, Nung Jan, Yuh

“…Neurons contain distinct compartments including dendrites, dendritic spines, axons and synaptic terminals. The molecular mechanisms that generate and…”
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Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia by Steullet, P, Cabungcal, J-H, Coyle, J, Didriksen, M, Gill, K, Grace, A A, Hensch, T K, LaMantia, A-S, Lindemann, L, Maynard, T M, Meyer, U, Morishita, H, O'Donnell, P, Puhl, M, Cuenod, M, Do, K Q

“…Parvalbumin inhibitory interneurons (PVIs) are crucial for maintaining proper excitatory/inhibitory balance and high-frequency neuronal synchronization. Their…”
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Genetic Otx2 mis-localization delays critical period plasticity across brain regions by Lee, H H C, Bernard, C, Ye, Z, Acampora, D, Simeone, A, Prochiantz, A, Di Nardo, A A, Hensch, T K

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Experience-Dependent Pruning of Dendritic Spines in Visual Cortex by Tissue Plasminogen Activator by Mataga, Nobuko, Mizuguchi, Yoko, Hensch, Takao K.

“…Sensory experience physically rewires the brain in early postnatal life through unknown processes. Here, we identify a robust anatomical consequence of…”
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Columnar Architecture Sculpted by GABA Circuits in Developing Cat Visual Cortex by Hensch, Takao K., Stryker, Michael P.

“…The mammalian visual cortex is organized into columns. Here, we examine cortical influences upon developing visual afferents in the cat by altering intrinsic…”
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Ocular Dominance Plasticity Under Metabotropic Glutamate Receptor Blockade by Hensch, Takao K., Stryker, Michael P.

“…Occluding vision through one eye during a critical period in early life nearly abolishes responses to that eye in visual cortex. This phenomenon is mimicked by…”
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Separable Features of Visual Cortical Plasticity Revealed by N-Methyl-D-Aspartate Receptor 2A Signaling by Fagiolini, Michela, Katagiri, Hiroyuki, Miyamoto, Hiroyuki, Mori, Hisashi, Seth G. N. Grant, Mishina, Masayoshi, Hensch, Takao K.

“…How individual receptive field properties are formed in the maturing sensory neocortex remains largely unknown. The shortening of N-methyl-D-aspartate (NMDA)…”
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Experience-Dependent Plasticity of Mouse Visual Cortex in the Absence of the Neuronal Activity-Dependent Marker egr1/zif268 by Mataga, Nobuko, Fujishima, Sayaka, Condie, Brian G, Hensch, Takao K

“…Neuronal activity elicits a rapid increase in the expression of several immediate early genes (IEGs). To clarify a role for IEG response in activity-dependent…”
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Experience-Dependent Plasticity without Long-Term Depression by Type 2 Metabotropic Glutamate Receptors in Developing Visual Cortex by Renger, John J., Hartman, Kenichi N., Tsuchimoto, Yoshiko, Yokoi, Mineto, Nakanishi, Shigetada, Hensch, Takao K.

“…Synaptic depression is thought to underlie the loss of cortical responsiveness to an eye deprived of vision. Here, we establish a fundamental role for type 2…”
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Experience-Dependent Transfer of Otx2 Homeoprotein into the Visual Cortex Activates Postnatal Plasticity by Sugiyama, Sayaka, Di Nardo, Ariel A., Aizawa, Shinichi, Matsuo, Isao, Volovitch, Michel, Prochiantz, Alain, Hensch, Takao K.

“…Neural circuits are shaped by experience in early postnatal life. Distinct GABAergic connections within visual cortex determine the timing of the critical…”
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A Theory of the Transition to Critical Period Plasticity: Inhibition Selectively Suppresses Spontaneous Activity by Toyoizumi, Taro, Miyamoto, Hiroyuki, Yazaki-Sugiyama, Yoko, Atapour, Nafiseh, Hensch, Takao K., Miller, Kenneth D.

“…What causes critical periods (CPs) to open? For the best-studied case, ocular dominance plasticity in primary visual cortex in response to monocular…”
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Whisking Away Space in the Brain by Hensch, Takao K.

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Critical period plasticity in local cortical circuits by Hensch, Takao K

“…Neuronal circuits in the brain are shaped by experience during 'critical periods' in early postnatal life. In the primary visual cortex, this…”
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Transcriptional Landscape of the Mammalian Genome by Carninci, P, Kasukawa, T, Katayama, S, Gough, J, Frith, M. C, Maeda, N, Oyama, R, Lenhard, B, Wells, C, Bajic, V. B, Brenner, S. E, Batalov, S, Forrest, A. R. R, Zavolan, M, Wilming, L. G, Ambesi-Impiombato, A, Aturaliya, R. N, Bailey, T. L, Bansal, M, Baxter, L, Beisel, K. W, Bono, H, Chalk, A. M, Chiu, K. P, Christoffels, A, Dalla, E, Dalrymple, B. P, de Bono, B, Down, T, Engstrom, P, Fagiolini, M, Faulkner, G, Furuno, M, Gingeras, T. R, Gojobori, T, Gustincich, S, Harbers, M, Hensch, T. K, Hirokawa, N, Hill, D, Ikeo, K, Ishikawa, T, Jakt, M, Kanapin, A, Katoh, M, Kawasawa, Y, Kitano, H, Kollias, G, Kurochkin, I. V, Lareau, L. F, Liu, J, Liuni, S, Madera, M, Matsuda, H, Matsuzawa, S, Morris, K, Nakano, N, Nishiguchi, S, Nishikawa, S, Nori, F, Pesole, G, Reed, J, Ruan, Y, Salzberg, S. L, Schneider, C, Sekiguchi, K, Semple, C. A. M, Sessa, L, Sheng, Y, Shibata, Y, Shimada, K, Sinclair, B, Sperling, S, Sultana, R, Taki, K, Ueda, H. R, Wei, C. L, Yamanishi, H, Zabarovsky, E, Zhu, S, Hide, W, Bult, C, Teasdale, R. D, Liu, E. T, Mattick, J. S, Hume, D. A, Kai, C, Sasaki, D, Kanamori-Katayama, M, Suzuki, M, Imamura, K, Itoh, M, Kato, T, Kawagashira, N, Nakano, K, Ninomiya, N, Okada, M, Suzuki, S, Watahiki, A, Kawai, J

“…This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs…”
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