Search Results - "Henry, Jake Y."

Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients by Rouet, Romain, Henry, Jake Y., Johansen, Matt D., Sobti, Meghna, Balachandran, Harikrishnan, Langley, David B., Walker, Gregory J., Lenthall, Helen, Jackson, Jennifer, Ubiparipovic, Stephanie, Mazigi, Ohan, Schofield, Peter, Burnett, Deborah L., Brown, Simon H. J., Martinello, Marianne, Hudson, Bernard, Gilroy, Nicole, Post, Jeffrey J., Kelleher, Anthony, Jäck, Hans-Martin, Goodnow, Christopher C., Turville, Stuart G., Rawlinson, William D., Bull, Rowena A., Stewart, Alastair G., Hansbro, Philip M., Christ, Daniel

“…Emerging variants of concern (VOCs) are threatening to limit the effectiveness of SARS-CoV-2 monoclonal antibodies and vaccines currently used in clinical…”
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Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies by Rouet, Romain, Mazigi, Ohan, Walker, Gregory J., Langley, David B., Sobti, Meghna, Schofield, Peter, Lenthall, Helen, Jackson, Jennifer, Ubiparipovic, Stephanie, Henry, Jake Y., Abayasingam, Arunasingam, Burnett, Deborah, Kelleher, Anthony, Brink, Robert, Bull, Rowena A., Turville, Stuart, Stewart, Alastair G., Goodnow, Christopher C., Rawlinson, William D., Christ, Daniel

“…Antibodies against coronavirus spike protein potently protect against infection and disease, but whether such protection can be extended to variant…”
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Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma by Simpson, Tyler R, Li, Fubin, Montalvo-Ortiz, Welby, Sepulveda, Manuel A, Bergerhoff, Katharina, Arce, Frederick, Roddie, Claire, Henry, Jake Y, Yagita, Hideo, Wolchok, Jedd D, Peggs, Karl S, Ravetch, Jeffrey V, Allison, James P, Quezada, Sergio A

“…Treatment with monoclonal antibody specific for cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), an inhibitory receptor expressed by T lymphocytes, has…”
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Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade by McGranahan, Nicholas, Furness, Andrew J. S., Rosenthal, Rachel, Ramskov, Sofie, Lyngaa, Rikke, Saini, Sunil Kumar, Jamal-Hanjani, Mariam, Wilson, Gareth A., Birkbak, Nicolai J., Hiley, Crispin T., Watkins, Thomas B. K., Shafi, Seema, Murugaesu, Nirupa, Mitter, Richard, Akarca, Ayse U., Linares, Joseph, Marafioti, Teresa, Henry, Jake Y., Van Allen, Eliezer M., Miao, Diana, Schilling, Bastian, Schadendorf, Dirk, Garraway, Levi A., Makarov, Vladimir, Rizvi, Naiyer A., Snyder, Alexandra, Hellmann, Matthew D., Merghoub, Taha, Wolchok, Jedd D., Shukla, Sachet A., Wu, Catherine J., Peggs, Karl S., Chan, Timothy A., Hadrup, Sine R., Quezada, Sergio A., Swanton, Charles

“…As tumors grow, they acquire mutations, some of which create neoantigens that influence the response of patients to immune checkpoint inhibitors. We explored…”
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Marrow-Infiltrating Regulatory T Cells Correlate with the Presence of Dysfunctional CD4 + PD-1 + Cells and Inferior Survival in Patients with Newly Diagnosed Multiple Myeloma by Alrasheed, Nouf, Lee, Lydia, Ghorani, Ehsan, Henry, Jake Y, Conde, Lucia, Chin, Melody, Galas-Filipowicz, Daria, Furness, Andrew J S, Chavda, Selina J, Richards, Huw, De-Silva, Dunnya, Cohen, Oliver C, Patel, Dominic, Brooks, Anthony, Rodriguez-Justo, Manuel, Pule, Martin, Herrero, Javier, Quezada, Sergio A, Yong, Kwee L

“…Immune dysregulation is described in multiple myeloma. While preclinical models suggest a role for altered T-cell immunity in disease progression, the…”
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Enhanced cross‐priming of naive CD8+ T cells by dendritic cells treated by the IMiDs® immunomodulatory compounds lenalidomide and pomalidomide by Henry, Jake Y., Labarthe, Marie‐Christine, Meyer, Brendan, Dasgupta, Prokar, Dalgleish, Angus G., Galustian, Christine

“…Summary The IMiDs® immunomodulatory compounds lenalidomide and pomalidomide are agents with anti‐inflammatory, immunomodulatory and anti‐cancer activity. An…”
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Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability by Burnett, Deborah L., Jackson, Katherine J.L., Langley, David B., Aggarwal, Anupriya, Stella, Alberto Ospina, Johansen, Matt D., Balachandran, Harikrishnan, Lenthall, Helen, Rouet, Romain, Walker, Gregory, Saunders, Bernadette M., Singh, Mandeep, Li, Hui, Henry, Jake Y., Jackson, Jennifer, Stewart, Alastair G., Witthauer, Franka, Spence, Matthew A., Hansbro, Nicole G., Jackson, Colin, Schofield, Peter, Milthorpe, Claire, Martinello, Marianne, Schulz, Sebastian R., Roth, Edith, Kelleher, Anthony, Emery, Sean, Britton, Warwick J., Rawlinson, William D., Karl, Rudolfo, Schäfer, Simon, Winkler, Thomas H., Brink, Robert, Bull, Rowena A., Hansbro, Philip M., Jäck, Hans-Martin, Turville, Stuart, Christ, Daniel, Goodnow, Christopher C.

“…Viral mutations are an emerging concern in reducing SARS-CoV-2 vaccination efficacy. Second-generation vaccines will need to elicit neutralizing antibodies…”
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Immune Surveillance in Clinical Regression of Preinvasive Squamous Cell Lung Cancer by Pennycuick, Adam, Teixeira, Vitor H, AbdulJabbar, Khalid, Raza, Shan E Ahmed, Lund, Tom, Akarca, Ayse U, Rosenthal, Rachel, Kalinke, Lukas, Chandrasekharan, Deepak P, Pipinikas, Christodoulos P, Lee-Six, Henry, Hynds, Robert E, Gowers, Kate H C, Henry, Jake Y, Millar, Fraser R, Hagos, Yeman B, Denais, Celine, Falzon, Mary, Moore, David A, Antoniou, Sophia, Durrenberger, Pascal F, Furness, Andrew J, Carroll, Bernadette, Marceaux, Claire, Asselin-Labat, Marie-Liesse, Larson, William, Betts, Courtney, Coussens, Lisa M, Thakrar, Ricky M, George, Jeremy, Swanton, Charles, Thirlwell, Christina, Campbell, Peter J, Marafioti, Teresa, Yuan, Yinyin, Quezada, Sergio A, McGranahan, Nicholas, Janes, Sam M

“…Before squamous cell lung cancer develops, precancerous lesions can be found in the airways. From longitudinal monitoring, we know that only half of such…”
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Human genomic DNA is widely interspersed with i-motif structures by Peña Martinez, Cristian David, Zeraati, Mahdi, Rouet, Romain, Mazigi, Ohan, Henry, Jake Y, Gloss, Brian, Kretzmann, Jessica A, Evans, Cameron W, Ruggiero, Emanuela, Zanin, Irene, Marušič, Maja, Plavec, Janez, Richter, Sara N, Bryan, Tracy M, Smith, Nicole M, Dinger, Marcel E, Kummerfeld, Sarah, Christ, Daniel

“…DNA i-motif structures are formed in the nuclei of human cells and are believed to provide critical genomic regulation. While the existence, abundance, and…”
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CD25-T reg -depleting antibodies preserving IL-2 signaling on effector T cells enhance effector activation and antitumor immunity by Solomon, Isabelle, Amann, Maria, Goubier, Anne, Arce Vargas, Frederick, Zervas, Dimitrios, Qing, Chen, Henry, Jake Y, Ghorani, Ehsan, Akarca, Ayse U, Marafioti, Teresa, Śledzińska, Anna, Werner Sunderland, Mariana, Franz Demane, Dafne, Clancy, Joanne Ruth, Georgiou, Andrew, Salimu, Josephine, Merchiers, Pascal, Brown, Mark Adrian, Flury, Reto, Eckmann, Jan, Murgia, Claudio, Sam, Johannes, Jacobsen, Bjoern, Marrer-Berger, Estelle, Boetsch, Christophe, Belli, Sara, Leibrock, Lea, Benz, Joerg, Koll, Hans, Sutmuller, Roger, Peggs, Karl S, Quezada, Sergio A

“…Intratumoral regulatory T cell (Treg) abundance associates with diminished anti-tumor immunity and poor prognosis in human cancers. Recent work demonstrates…”
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CD25-Treg-depleting antibodies preserving IL-2 signaling on effector T cells enhance effector activation and antitumor immunity by Solomon, Isabelle, Amann, Maria, Goubier, Anne, Arce Vargas, Frederick, Zervas, Dimitrios, Qing, Chen, Henry, Jake Y., Ghorani, Ehsan, Akarca, Ayse U., Marafioti, Teresa, Śledzińska, Anna, Werner Sunderland, Mariana, Franz Demane, Dafne, Clancy, Joanne Ruth, Georgiou, Andrew, Salimu, Josephine, Merchiers, Pascal, Brown, Mark Adrian, Flury, Reto, Eckmann, Jan, Murgia, Claudio, Sam, Johannes, Jacobsen, Bjoern, Marrer-Berger, Estelle, Boetsch, Christophe, Belli, Sara, Leibrock, Lea, Benz, Joerg, Koll, Hans, Sutmuller, Roger, Peggs, Karl S., Quezada, Sergio A.

“…Intratumoral regulatory T cell (Treg) abundance associates with diminished anti-tumor immunity and poor prognosis in human cancers. Recent work demonstrates…”
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TALEN-mediated genetic inactivation of the glucocorticoid receptor in cytomegalovirus-specific T cells by Menger, Laurie, Gouble, Agnes, Marzolini, Maria A.V., Pachnio, Annette, Bergerhoff, Katharina, Henry, Jake Y., Smith, Julianne, Pule, Martin, Moss, Paul, Riddell, Stanley R., Quezada, Sergio A., Peggs, Karl S.

“…Cytomegalovirus (CMV) infection is responsible for substantial morbidity and mortality after allogeneic hematopoietic stem cell transplant. T-cell immunity is…”
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CMV promotes recipient T-cell immunity following reduced-intensity T-cell–depleted HSCT, significantly modulating chimerism status by Sellar, Rob S., Vargas, Frederick Arce, Henry, Jake Y., Verfuerth, Stephanie, Charrot, Sarah, Beaton, Brendan, Chakraverty, Ronjon, Quezada, Sergio A., Mackinnon, Stephen, Thomson, Kirsty J., Peggs, Karl S.

“…Cytomegalovirus (CMV) remains a significant cause of morbidity after allogeneic hematopoietic stem cell transplantation (HSCT). Clinical risk varies according…”
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Platform for isolation and characterization of SARS-CoV-2 variants enables rapid characterization of Omicron in Australia by Aggarwal, Anupriya, Stella, Alberto Ospina, Walker, Gregory, Akerman, Anouschka, Esneau, Camille, Milogiannakis, Vanessa, Burnett, Deborah L., McAllery, Samantha, Silva, Mariana Ruiz, Lu, Yonghui, Foster, Charles S. P., Brilot, Fabienne, Pillay, Aleha, Van Hal, Sabastiaan, Mathivanan, Vennila, Fichter, Christina, Kindinger, Andrea, Hoppe, Alexandra Carey, Munier, Mee Ling, Amatayakul-Chantler, Supavadee, Roth, Nathan, Coppola, Germano, Symonds, Geoff P., Schofield, Peter, Jackson, Jennifer, Lenthall, Helen, Henry, Jake Y., Mazigi, Ohan, Jäck, Hans-Martin, Davenport, Miles P., Darley, David R., Matthews, Gail V., Khoury, David S., Cromer, Deborah, Goodnow, Christopher C., Christ, Daniel, Robosa, Roselle, Starck, Damien J., Bartlett, Nathan W., Rawlinson, William D., Kelleher, Anthony D., Turville, Stuart G.

“…Genetically distinct variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged since the start of the COVID-19 pandemic. Over this…”
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The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+ Macrophages or Monocyte-Derived Dendritic Cells by Menezes, Shinelle, Melandri, Daisy, Anselmi, Giorgio, Perchet, Thibaut, Loschko, Jakob, Dubrot, Juan, Patel, Rajen, Gautier, Emmanuel L., Hugues, Stéphanie, Longhi, M. Paula, Henry, Jake Y., Quezada, Sergio A., Lauvau, Grégoire, Lennon-Duménil, Ana-Maria, Gutiérrez-Martínez, Enrique, Bessis, Alain, Gomez-Perdiguero, Elisa, Jacome-Galarza, Christian E., Garner, Hannah, Geissmann, Frederic, Golub, Rachel, Nussenzweig, Michel C., Guermonprez, Pierre

“…Inflammation triggers the differentiation of Ly6Chi monocytes into microbicidal macrophages or monocyte-derived dendritic cells (moDCs). Yet, it is unclear…”
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microarray study of altered gene expression in colorectal cancer cells after treatment with immunomodulatory drugs: differences in action in vivo and in vitro by Liu, Wai M, Laux, Holger, Henry, Jake Y, Bolton, Thomas B, Dalgleish, Angus G, Galustian, Christine

“…Thalidomide and lenalidomide are FDA approved for the treatment of multiple myeloma, and along with pomalidomide are being investigated in a variety of other…”
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The T cell differentiation landscape is shaped by tumour mutations in lung cancer by Ghorani, Ehsan, Reading, James L, Henry, Jake Y, Massy, Marc Robert de, Rosenthal, Rachel, Turati, Virginia, Joshi, Kroopa, Furness, Andrew J S, Ben Aissa, Assma, Saini, Sunil Kumar, Ramskov, Sofie, Georgiou, Andrew, Sunderland, Mariana Werner, Wong, Yien Ning Sophia, Mucha, Maria Vila De, Day, William, Galvez-Cancino, Felipe, Becker, Pablo D, Uddin, Imran, Oakes, Theres, Ismail, Mazlina, Ronel, Tahel, Woolston, Annemarie, Jamal-Hanjani, Mariam, Veeriah, Selvaraju, Birkbak, Nicolai J, Wilson, Gareth A, Litchfield, Kevin, Conde, Lucia, Guerra-Assunção, José Afonso, Blighe, Kevin, Biswas, Dhruva, Salgado, Roberto, Lund, Tom, Bakir, Maise Al, Moore, David A, Hiley, Crispin T, Loi, Sherene, Sun, Yuxin, Yuan, Yinyin, AbdulJabbar, Khalid, Turajilic, Samra, Herrero, Javier, Enver, Tariq, Hadrup, Sine R, Hackshaw, Allan, Peggs, Karl S, McGranahan, Nicholas, Chain, Benny, Swanton, Charles, Quezada, Sergio A

“…Tumour mutational burden (TMB) predicts immunotherapy outcome in non-small cell lung cancer (NSCLC), consistent with immune recognition of tumour neoantigens…”
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Abstract 3812: A best in class anti-CD38 antibody with antitumor and immune-modulatory properties by Eissler, Nina, Filosto, Simone, Henry, Jake Y., Maguire, Michael F., Witt, Kristina, Lundqvist, Andreas, Marafioti, Teresa, Merchiers, Pascal, Moulder, Kevin, Goyenechea, Beatriz, Lu, Haw, Fairbairn, Camilla, Windler, Sarah, Aurellano, JD, Duramad, Omar, Smethurst, Dominic, Quezada, Sergio A., Goubier, Anne

“…Abstract Targeting CD38 in multiple myeloma has resulted in outstanding responses. CD38 is widely expressed on myeloma cells and other hematological…”
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Association of the imbalance between early and late differentiated intra-tumor CD4 T cells with mutational burden in non-small cell lung cancer by Ghorani, Ehsan, Reading, James L., Henry, Jake Y., Robert De Massy, Marc, Rosenthal, Rachel, Furness, Andrew J.S., Ben Aissa, Assma, Jamal-Hanjani, Mariam, Birkbak, Nicolai, Wilson, Gareth, Salgado, Roberto, Lund, Tom, Hiley, Crispin T., Loi, Sherene, Hackshaw, Allan, McGranahan, Nicholas, Chain, Benjamin M., Peggs, Karl S., Swanton, Charles, Quezada, Sergio A.

“…Abstract only 2590 Background: CD4 T helper cells are key orchestrators of immunity in states of persistent antigen exposure. In chronic viral infection, loss…”
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The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+ Macrophages or Monocyte-Derived Dendritic Cells by Menezes, Shinelle, Melandri, Daisy, Anselmi, Giorgio, Perchet, Thibaut, Loschko, Jakob, Dubrot, Juan, Patel, Rajen, Gautier, Emmanuel L., Hugues, Stéphanie, Longhi, M. Paula, Henry, Jake Y., Quezada, Sergio A., Lauvau, Grégoire, Lennon-Duménil, Ana-Maria, Gutiérrez-Martínez, Enrique, Bessis, Alain, Gomez-Perdiguero, Elisa, Jacome-Galarza, Christian E., Garner, Hannah, Geissmann, Frederic, Golub, Rachel, Nussenzweig, Michel C., Guermonprez, Pierre

“…Inflammation triggers the differentiation of Ly6C(hi) monocytes into microbicidal macrophages or monocyte-derived dendritic cells (moDCs). Yet, it is unclear…”
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