Search Results - "Henry, J M"

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy by Dörr, Jan R., Yu, Yong, Milanovic, Maja, Beuster, Gregor, Zasada, Christin, Däbritz, J. Henry M., Lisec, Jan, Lenze, Dido, Gerhardt, Anne, Schleicher, Katharina, Kratzat, Susanne, Purfürst, Bettina, Walenta, Stefan, Mueller-Klieser, Wolfgang, Gräler, Markus, Hummel, Michael, Keller, Ulrich, Buck, Andreas K., Dörken, Bernd, Willmitzer, Lothar, Reimann, Maurice, Kempa, Stefan, Lee, Soyoung, Schmitt, Clemens A.

“…In mice with Eµ- myc transgenic lymphomas in which therapy-induced senescence (TIS) depends on the H3K9 histone methyltransferase Suv39h1, TIS-competent…”
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Senescence-associated reprogramming promotes cancer stemness by Milanovic, Maja, Fan, Dorothy N. Y., Belenki, Dimitri, Däbritz, J. Henry M., Zhao, Zhen, Yu, Yong, Dörr, Jan R., Dimitrova, Lora, Lenze, Dido, Monteiro Barbosa, Ines A., Mendoza-Parra, Marco A., Kanashova, Tamara, Metzner, Marlen, Pardon, Katharina, Reimann, Maurice, Trumpp, Andreas, Dörken, Bernd, Zuber, Johannes, Gronemeyer, Hinrich, Hummel, Michael, Dittmar, Gunnar, Lee, Soyoung, Schmitt, Clemens A.

“…Cellular senescence induced by chemotherapy leads to the acquisition of stemness in cancer cells, which results in enhanced tumour-promoting capacity after…”
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Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages by Mills, Evanna L., Kelly, Beth, Logan, Angela, Costa, Ana S.H., Varma, Mukund, Bryant, Clare E., Tourlomousis, Panagiotis, Däbritz, J. Henry M., Gottlieb, Eyal, Latorre, Isabel, Corr, Sinéad C., McManus, Gavin, Ryan, Dylan, Jacobs, Howard T., Szibor, Marten, Xavier, Ramnik J., Braun, Thomas, Frezza, Christian, Murphy, Michael P., O’Neill, Luke A.

“…Activated macrophages undergo metabolic reprogramming, which drives their pro-inflammatory phenotype, but the mechanistic basis for this remains obscure. Here,…”
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Comparative Greenhouse Gas Footprinting of Online versus Traditional Shopping for Fast-Moving Consumer Goods: A Stochastic Approach by Shahmohammadi, Sadegh, Steinmann, Zoran J. N, Tambjerg, Lau, van Loon, Patricia, King, J. M. Henry, Huijbregts, Mark A. J

“…Variability in consumer practices and choices is typically not addressed in comparisons of environmental impacts of traditional shopping and e-commerce. Here,…”
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RUNX1 Is a Driver of Renal Cell Carcinoma Correlating with Clinical Outcome by Rooney, Nicholas, Mason, Susan M, McDonald, Laura, Däbritz, J Henry M, Campbell, Kirsteen J, Hedley, Ann, Howard, Steven, Athineos, Dimitris, Nixon, Colin, Clark, William, Leach, Joshua D G, Sansom, Owen J, Edwards, Joanne, Cameron, Ewan R, Blyth, Karen

“…The recurring association of specific genetic lesions with particular types of cancer is a fascinating and largely unexplained area of cancer biology. This is…”
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Research into cancer metabolomics: Towards a clinical metamorphosis by Olivares, Orianne, Däbritz, J. Henry M., King, Ayala, Gottlieb, Eyal, Halsey, Christina

“…•Metabolism-related tools are employed to diagnose and treat cancer.•Promising metabolic tracers and anti-cancer drugs are in clinical trials.•Metabolomics…”
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Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix by Kay, Emily J., Paterson, Karla, Riera-Domingo, Carla, Sumpton, David, Däbritz, J. Henry M., Tardito, Saverio, Boldrini, Claudia, Hernandez-Fernaud, Juan R., Athineos, Dimitris, Dhayade, Sandeep, Stepanova, Ekaterina, Gjerga, Enio, Neilson, Lisa J., Lilla, Sergio, Hedley, Ann, Koulouras, Grigorios, McGregor, Grace, Jamieson, Craig, Johnson, Radia Marie, Park, Morag, Kirschner, Kristina, Miller, Crispin, Kamphorst, Jurre J., Loayza-Puch, Fabricio, Saez-Rodriguez, Julio, Mazzone, Massimiliano, Blyth, Karen, Zagnoni, Michele, Zanivan, Sara

“…Elevated production of collagen-rich extracellular matrix is a hallmark of cancer-associated fibroblasts (CAFs) and a central driver of cancer aggressiveness…”
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PD-L1 and PD-L2 Expression in Cervical Cancer: Regulation and Biomarker Potential by Rotman, Jossie, den Otter, Leontine A S, Bleeker, Maaike C G, Samuels, Sanne S, Heeren, A Marijne, Roemer, Margaretha G M, Kenter, Gemma G, Zijlmans, Henry J M A A, van Trommel, Nienke E, de Gruijl, Tanja D, Jordanova, Ekaterina S

“…PD-1/PD-L1 immune checkpoint inhibitors show potential for cervical cancer treatment. However, low response rates suggest that patient selection based on PD-L1…”
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Advances in ET-based landscape irrigation management by Snyder, R.L., Pedras, C., Montazar, A., Henry, J.M., Ackley, D.

“…•Techniques to determine landscape ET are compatible and useful in agriculture.•Surface renewal permits ET estimation in locations with less fetch.•The ratio…”
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Individual neurophysiological signatures of spontaneous rhythm processing by Criscuolo, A., Schwartze, M., Henry, M.J., Obermeier, C., Kotz, S.A.

“…•Neural oscillations sample the acoustic environment at multiple timescales.•Delta-band oscillations encode temporal regularities and predict tone…”
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A multicentre cohort study assessing day of week effect and outcome from emergency appendicectomy by Ferguson, Henry J M, Hall, Nigel J, Bhangu, Aneel

“…There is evidence to suggest that patients undergoing treatment at weekends may be subject to different care processes and outcomes compared with weekdays…”
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The population burden of fractures originates in women with osteopenia, not osteoporosis by PASCO, J. A, SEEMAN, E, HENRY, M. J, MERRIMAN, E. N, NICHOLSON, G. C, KOTOWICZ, M. A

“…Osteoporosis is associated with increased risk for fracture. However, most postmenopausal women have bone mineral density (BMD) within the normal or osteopenic…”
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Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin lymphoma by Du, Jing, Neuenschwander, Martin, Yu, Yong, Däbritz, J.Henry M., Neuendorff, Nina-Rosa, Schleich, Kolja, Bittner, Aitomi, Milanovic, Maja, Beuster, Gregor, Radetzki, Silke, Specker, Edgar, Reimann, Maurice, Rosenbauer, Frank, Mathas, Stephan, Lohneis, Philipp, Hummel, Michael, Dörken, Bernd, von Kries, Jens Peter, Lee, Soyoung, Schmitt, Clemens A.

“…Classical Hodgkin lymphoma (cHL), although originating from B cells, is characterized by the virtual lack of gene products whose expression constitutes the…”
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CD20-Targeting Immunotherapy Promotes Cellular Senescence in B-Cell Lymphoma by Däbritz, J Henry M, Yu, Yong, Milanovic, Maja, Schönlein, Martin, Rosenfeldt, Mathias T, Dörr, Jan R, Kaufmann, Andreas M, Dörken, Bernd, Schmitt, Clemens A

“…The CD20-targeting monoclonal antibody rituximab is an established component of immunochemotherapeutic regimens against B-cell lymphomas, where its…”
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Bone mineral density reference ranges for Australian men: Geelong Osteoporosis Study by Henry, M. J, Pasco, J. A, Korn, S, Gibson, J. E, Kotowicz, M. A, Nicholson, G. C

“…Summary A large population-based random sample of Australian white men was used to provide normative bone mineral density (BMD) data at multiple anatomical…”
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MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome by Wragg, Joseph W, Finnity, Jonathan P, Anderson, Jane A, Ferguson, Henry J M, Porfiri, Emilio, Bhatt, Rupesh I, Murray, Paul G, Heath, Victoria L, Bicknell, Roy

“…The structure and molecular signature of tumor-associated vasculature are distinct from those of the host tissue, offering an opportunity to selectively target…”
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Farmer‐led badger vaccination in Cornwall: Epidemiological patterns and social perspectives by Woodroffe, Rosie, Astley, Kelly, Barnecut, Rose, Brotherton, Peter N. M., Donnelly, Christl A., Grub, Henry M. J., Ham, Cally, Howe, Caroline, Jones, Chris, Marriott, Cheryl, Miles, Verity, Rowcliffe, Marcus, Shelley, Tom, Truscott, Keith

“…In the United Kingdom, the management of bovine tuberculosis (bTB) challenges the coexistence of people and wildlife. Control of this cattle disease is…”
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Multi-omics & pathway analysis identify potential roles for tumor N-acetyl aspartate accumulation in murine models of castration-resistant prostate cancer by Salji, Mark J., Blomme, Arnaud, Däbritz, J. Henry M., Repiscak, Peter, Lilla, Sergio, Patel, Rachana, Sumpton, David, van den Broek, Niels J.F., Daly, Ronan, Zanivan, Sara, Leung, Hing Y.

“…Castration-resistant prostate cancer (CRPC) is incurable and remains a significant worldwide challenge (Oakes and Papa, 2015). Matched untargeted multi-level…”
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Immune landscape in vulvar cancer-draining lymph nodes indicates distinct immune escape mechanisms in support of metastatic spread and growth by Heeren, Anne Marijne, Rotman, Jossie, Samuels, Sanne, Zijlmans, Henry J M A A, Fons, Guus, van de Vijver, Koen K, Bleeker, Maaike C G, Kenter, Gemma G, Jordanova, Ekaterina J, de Gruijl, Tanja D

“…BackgroundTherapeutic immune intervention is highly dependent on the T-cell priming and boosting capacity of tumor-draining lymph nodes (TDLN). In vulvar…”
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Morphometric vertebral fractures of the lower thoracic and lumbar spine, physical function and quality of life in men by Pasco, J. A, Henry, M. J, Korn, S, Nicholson, G. C, Kotowicz, M. A

“…Summary The epidemiology and sequelae of morphometric vertebral fracture (MVF) are poorly documented. We found that MVFs of the lower thoracic and lumbar spine…”
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