Search Results - "Henry, Eric R."

Comparing a simple theoretical model for protein folding with all-atom molecular dynamics simulations by Henry, Eric R., Best, Robert B., Eaton, William A.

“…Advances in computing have enabled microsecond all-atom molecular dynamics trajectories of protein folding that can be used to compare with and test critical…”
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Experimental basis for a new allosteric model for multisubunit proteins by Viappiani, Cristiano, Abbruzzetti, Stefania, Ronda, Luca, Bettati, Stefano, Henry, Eric. R., Mozzarelli, Andrea, Eaton, William A.

“…Monod, Wyman, and Changeux (MWC) explained allostery in multisubunit proteins with a widely applied theoretical model in which binding of small molecules,…”
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Watching a signaling protein function in real time via 100-ps time-resolved Laue crystallography by Schotte, Friedrich, Cho, Hyun Sun, Kaila, Ville R. I, Kamikubo, Hironari, Dashdorj, Naranbaatar, Henry, Eric R, Graber, Timothy J, Henning, Robert, Wulff, Michael, Hummer, Gerhard, Kataoka, Mikio, Anfinrud, Philip A

“…To understand how signaling proteins function, it is crucial to know the time-ordered sequence of events that lead to the signaling state. We recently…”
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Measuring internal friction of an ultrafast-folding protein by Cellmer, Troy, Henry, Eric R, Hofrichter, James, Eaton, William A

“…Nanosecond laser T-jump was used to measure the viscosity dependence of the folding kinetics of the villin subdomain under conditions where the viscogen has no…”
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Experiments on Hemoglobin in Single Crystals and Silica Gels Distinguish among Allosteric Models by Henry, Eric R., Mozzarelli, Andrea, Viappiani, Cristiano, Abbruzzetti, Stefania, Bettati, Stefano, Ronda, Luca, Bruno, Stefano, Eaton, William A.

“…Trapping quaternary structures of hemoglobin in single crystals or by encapsulation in silica gels has provided a demanding set of data to test statistical…”
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Chemical, physical, and theoretical kinetics of an ultrafast folding protein by Kubelka, Jan, Henry, Eric R, Cellmer, Troy, Hofrichter, James, Eaton, William A

“…An extensive set of equilibrium and kinetic data is presented and analyzed for an ultrafast folding protein--the villin subdomain. The equilibrium data consist…”
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Making connections between ultrafast protein folding kinetics and molecular dynamics simulations by Cellmer, Troy, Buscaglia, Marco, Henry, Eric R, Hofrichter, James, Eaton, William A

“…Determining the rate of forming the truly folded conformation of ultrafast folding proteins is an important issue for both experiments and simulations. The…”
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Estimating Free-Energy Barrier Heights for an Ultrafast Folding Protein from Calorimetric and Kinetic Data by Godoy-Ruiz, Raquel, Henry, Eric R, Kubelka, Jan, Hofrichter, James, Muñoz, Victor, Sanchez-Ruiz, Jose M, Eaton, William A

“…Differential scanning calorimetry was used to measure the temperature dependence of the absolute heat capacity of the 35-residue subdomain of the villin…”
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Evolution of allosteric models for hemoglobin by Eaton, William A., Henry, Eric R., Hofrichter, James, Bettati, Stefano, Viappiani, Cristiano, Mozzarelli, Andrea

“…We compare various allosteric models that have been proposed to explain cooperative oxygen binding to hemoglobin, including the two‐state allosteric model of…”
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Relaxation Rate for an Ultrafast Folding Protein Is Independent of Chemical Denaturant Concentration by Cellmer, Troy, Henry, Eric R, Kubelka, Jan, Hofrichter, James, Eaton, William A

“…The connection between free-energy surfaces and chevron plots has been investigated in a laser temperature jump kinetic study of a small ultrafast folding…”
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A Statistical Mechanical Model for β -hairpin Kinetics by Munoz, Victor, Henry, Eric R., Hofrichter, James, Eaton, William A.

“…Understanding the mechanism of protein secondary structure formation is an essential part of the protein-folding puzzle. Here, we describe a simple statistical…”
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A tertiary two-state allosteric model for hemoglobin by Henry, Eric R., Bettati, Stefano, Hofrichter, James, Eaton, William A.

“…The two-state allosteric model of Monod, Wyman, and Changeux (MWC) provides an excellent description of homotropic effects in a vast array of equilibrium and…”
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Treatment of sickle cell disease by increasing oxygen affinity of hemoglobin by Henry, Eric R., Metaferia, Belhu, Li, Quan, Harper, Julia, Best, Robert B., Glass, Kristen E., Cellmer, Troy, Dunkelberger, Emily B., Conrey, Anna, Thein, Swee Lay, Bunn, H. Franklin, Eaton, William A.

“…The issue of treating sickle cell disease with drugs that increase hemoglobin oxygen affinity has come to the fore with the US Food and Drug Administration…”
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Theoretical Simulation of Red Cell Sickling Upon Deoxygenation Based on the Physical Chemistry of Sickle Hemoglobin Fiber Formation by Dunkelberger, Emily B, Metaferia, Belhu, Cellmer, Troy, Henry, Eric R

“…The polymerization of the mutant hemoglobin S upon deoxygenation to form fibers in red blood cells of patients suffering from sickle-cell anemia results in…”
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MWC allosteric model explains unusual hemoglobin-oxygen binding curves from sickle cell drug binding by Henry, Eric R., Harper, Julia, Glass, Kristen E., Metaferia, Belhu, Louis, John M., Eaton, William A.

“…An oxygen-affinity-modifying drug, voxelotor, has very recently been approved by the FDA for treatment of sickle cell disease. The proposed mechanism of action…”
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Allosteric control of hemoglobin S fiber formation by oxygen and its relation to the pathophysiology of sickle cell disease by Henry, Eric R., Cellmer, Troy, Dunkelberger, Emily B., Metaferia, Belhu, Hofrichter, James, Li, Quan, Ostrowski, David, Ghirlando, Rodolfo, Louis, John M., Moutereau, Stéphane, Galactéros, Frédéric, Thein, Swee Lay, Bartolucci, Pablo, Eaton, William A.

“…The pathology of sickle cell disease is caused by polymerization of the abnormal hemoglobin S upon deoxygenation in the tissues to form fibers in red cells,…”
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Phenotypic screening of the ReFRAME drug repurposing library to discover new drugs for treating sickle cell disease by Metaferia, Belhu, Cellmer, Troy, Dunkelberger, Emily B, Li, Quan, Henry, Eric R, Hofrichter, James, Staton, Dwayne, Hsieh, Matthew M, Conrey, Anna K, Tisdale, John F, Chatterjee, Arnab K, Thein, Swee Lay, Eaton, William A

“…Stem cell transplantation and genetic therapies offer potential cures for patients with sickle cell disease (SCD), but these options require advanced medical…”
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The Role of Solvent Viscosity in the Dynamics of Protein Conformational Changes by Ansari, Anjum, Jones, Colleen M., Henry, Eric R., Hofrichter, James, Eaton, William A.

“…Nanosecond lasers were used to measure the rate of conformational changes in myoglobin after ligand dissociation at ambient temperatures. At low solvent…”
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Kinetic assay shows that increasing red cell volume could be a treatment for sickle cell disease by Li, Quan, Henry, Eric R., Hofrichter, James, Smith, Jeffrey F., Cellmer, Troy, Dunkelberger, Emily B., Metaferia, Belhu B., Jones-Straehle, Stacy, Boutom, Sarah, Christoph, Garrott W., Wakefield, Terri H., Link, Mary E., Staton, Dwayne, Vass, Erica R., Miller, Jeffery L., Hsieh, Matthew M., Tisdale, John F., Eaton, William A.

“…Although it has been known for more than 60 years that the cause of sickle cell disease is polymerization of a hemoglobin mutant, hydroxyurea is the only drug…”
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Interactions of an Anti-Sickling Drug with Hemoglobin in Red Blood Cells from a Patient with Sickle Cell Anemia by Strader, Michael Brad, Liang, Hongying, Meng, Fantao, Harper, Julia, Ostrowski, David A, Henry, Eric R, Shet, Arun S, Eaton, William A, Thein, Swee L, Alayash, Abdu I

“…The pathophysiology associated with sickle cell disease (SCD) includes hemolytic anemia, vaso-occlusive events, and ultimately end organ damage set off by the…”
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