Search Results - "Henry, Ellen C"

(−)-Epigallocatechin-3-gallate Is a Novel Hsp90 Inhibitor by Yin, Zhengyu, Henry, Ellen C, Gasiewicz, Thomas A

“…(−)-Epigallocatechin-3-gallate (EGCG), a major component of green tea, protects against certain types of cancers, although the mechanism has not yet been…”
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The heat shock protein 90 inhibitor, (-)-epigallocatechin gallate, has anticancer activity in a novel human prostate cancer progression model by Moses, Michael A, Henry, Ellen C, Ricke, William A, Gasiewicz, Thomas A

“…(-)-Epigallocatechin gallate (EGCG), a major tea polyphenol, elicits anticancer effects. However, the mechanism of action is not fully understood. Our…”
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Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor by Kim, Sun-Hee, Henry, Ellen C, Kim, Dong-Kyu, Kim, Yun-Hee, Shin, Kum Joo, Han, Myoung Sook, Lee, Taehoon G, Kang, Jong-Ku, Gasiewicz, Thomas A, Ryu, Sung Ho, Suh, Pann-Ghill

“…2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental pollutant with many toxic effects, including endocrine disruption, reproductive…”
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Towards the discovery of drug-like epigallocatechin gallate analogs as Hsp90 inhibitors by Bhat, Rohit, Adam, Amna T., Lee, Jungeun Jasmine, Gasiewicz, Thomas A., Henry, Ellen C., Rotella, David P.

“…(−)-Epigallocatechin gallate (EGCG) is the major flavonoid of green tea and has been widely explored for a range of biological activities including…”
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Aryl Hydrocarbon Receptor Deficiency in an Exon 3 Deletion Mouse Model Promotes Hematopoietic Stem Cell Proliferation and Impacts Endosteal Niche Cells by Bennett, John A., Donegan, Catherine L., Henry, Ellen C., Singh, Kameshwar P., Unnisa, Zeenath, Gasiewicz, Thomas A.

“…The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor belonging to the Per-Arnt-Sim (PAS) family of proteins. The AHR is involved in…”
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Species-specific transcriptional activity of synthetic flavonoids in guinea pig and mouse cells as a result of differential activation of the aryl hydrocarbon receptor to interact with dioxin-responsive elements by Zhou, Jun-Guo, Henry, Ellen C, Palermo, Christine M, Dertinger, Stephen D, Gasiewicz, Thomas A

“…To investigate possible species-specificity of aryl hydrocarbon receptor (AhR)-mediated signal transduction pathways, activities of…”
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TCDD and a Putative Endogenous AhR Ligand, ITE, Elicit the Same Immediate Changes in Gene Expression in Mouse Lung Fibroblasts by Henry, Ellen C., Welle, Stephen L., Gasiewicz, Thomas A.

“…The aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor, mediates toxicity of several classes of xenobiotics and also has important…”
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Expression and activity of aryl hydrocarbon receptors in development and cancer by Gasiewicz, Thomas A, Henry, Ellen C, Collins, Loretta L

“…Although the aryl hydrocarbon receptor (AhR) has been known as the mediator of the toxicity of particular xenobiotics such as the dioxins, the normal role of…”
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Neural precursor cell proliferation is disrupted through activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin by Latchney, Sarah E, Lioy, Daniel T, Henry, Ellen C, Gasiewicz, Thomas A, Strathmann, Frederick G, Mayer-Pröschel, Margot, Opanashuk, Lisa A

“…Neurogenesis involves the proliferation of multipotent neuroepithelial stem cells followed by differentiation into lineage-restricted neural precursor cells…”
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Characterization of multiple forms of the Ah receptor: comparison of species and tissues by Henry, Ellen C, Rucci, George, Gasiewicz, Thomas A

“…Biochemical and toxic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) appear to be mediated via the Ah receptor, a gene-regulatory protein that, like…”
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Flavone antagonists bind competitively with 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) to the aryl hydrocarbon receptor but inhibit nuclear uptake and transformation by Henry, E C, Kende, A S, Rucci, G, Totleben, M J, Willey, J J, Dertinger, S D, Pollenz, R S, Jones, J P, Gasiewicz, T A

“…Previous analyses suggested that potent aryl hydrocarbon receptor (AhR) antagonists were planar, with a lateral electron-rich center. To further define…”
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Characterization of multiple forms of the Ah receptor: recognition of a dioxin-responsive enhancer involves heteromer formation by Gasiewicz, Thomas A, Elferink, Cornelis J, Henry, Ellen C

“…We have employed a combination of gel retardation, protein-DNA cross-linking, and protein-protein cross-linking techniques to further examine the…”
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The Heat Shock Protein 90 Inhibitor, Epigallocatechin Gallate, has Anti-Cancer Activity in a Novel Human Prostate Cancer Progression Model by Moses, Michael A., Henry, Ellen C., Ricke, William A., Gasiewicz, Thomas A.

“…(−)-Epigallocatechin gallate (EGCG), a major tea polyphenol, elicits anti-cancer effects. However, the mechanism of action is not fully understood. Our…”
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Agonist but not antagonist ligands induce conformational change in the mouse aryl hydrocarbon receptor as detected by partial proteolysis by Henry, E C, Gasiewicz, T A

“…The cytosolic transcription factor known as the aryl hydrocarbon receptor (AhR) undergoes transformation to a DNA-binding form by a series of processes…”
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Regulation of DNA Binding Activity of the Ligand-Activated Aryl Hydrocarbon Receptor by Tyrosine Phosphorylation by Park, Sang-ki, Henry, Ellen C., Gasiewicz, Thomas A.

“…Aryl hydrocarbon receptor (AhR), a member of the bHLH–PAS family, is a ligand-activated transcription factor which plays an important role in normal liver…”
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DNA Binding and Transcriptional Enhancement by Purified TCDD·Ah Receptor Complex by Henry, Ellen C., Kent, Terrie A., Gasiewicz, Thomas A.

“…The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional enhancer which mediates the biochemical and toxic effects of…”
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Induction of CYP1A1 and ALDH-3 in Lymphoid Tissues from Fisher 344 Rats Exposed to 2,3,7,8-Tetrachlorodibenzodioxin (TCDD) by Germolec, Dori R., Henry, Ellen C., Maronpot, Robert, Foley, Julie F., Adams, Nancy H., Gasiewicz, Thomas A., Luster, Michael I.

“…The immune system is a primary target for toxic insult by a number of drugs and environmental chemicals, many of which require activation to toxic metabolites…”
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Changes in thyroid hormones and thyroxine glucuronidation in hamsters compared with rats following treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin by Henry, E C, Gasiewicz, T A

“…In rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds, serum thyroxine (T4) is depressed. Since hamsters are relatively…”
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Purification to homogeneity of the heteromeric DNA-binding form of the aryl hydrocarbon receptor from rat liver by Henry, E C, Rucci, G, Gasiewicz, T A

“…The aryl hydrocarbon receptor (AhR) is a transcriptional enhancer that is activated by the binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related…”
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Inhibition and reconstitution of Ah receptor transformation in vitro: role and partial characterization of a cytosolic factor(s) by Henry, E C, Gasiewicz, T A

“…The Ah receptor binds 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related aryl hydrocarbons and mediates their biochemical and toxic effects by modifying…”
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