Search Results - "Henriques, Sónia T"

Converting peptides into drugs targeting intracellular protein–protein interactions by Philippe, Grégoire J.B., Craik, David J., Henriques, Sónia T.

“…•Cyclic peptides are ideal inhibitors of protein–protein interactions (PPIs), due to low immunogenicity and large surface area.•Peptide libraries are excellent…”
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Precision medicine by designer interference peptides: applications in oncology and molecular therapeutics by Sorolla, Anabel, Wang, Edina, Golden, Emily, Duffy, Ciara, Henriques, Sónia T., Redfern, Andrew D., Blancafort, Pilar

“…In molecular cancer therapeutics only 10% of known cancer gene products are targetable with current pharmacological agents. Major oncogenic drivers, such as…”
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Ozone-enabled fatty acid discovery reveals unexpected diversity in the human lipidome by Menzel, Jan Philipp, Young, Reuben S. E., Benfield, Aurélie H., Scott, Julia S., Wongsomboon, Puttandon, Cudlman, Lukáš, Cvačka, Josef, Butler, Lisa M., Henriques, Sónia T., Poad, Berwyck L. J., Blanksby, Stephen J.

“…Fatty acid isomers are responsible for an under-reported lipidome diversity across all kingdoms of life. Isomers of unsaturated fatty acids are often masked in…”
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Unlocking the Potential of the Antimicrobial Peptide Gomesin: From Discovery and Structure-Activity Relationships to Therapeutic Applications by Liu, Xiaorong, Henriques, Sónia T, Craik, David J, Chan, Lai Yue

“…Gomesin is a cationic antimicrobial peptide which is isolated from the haemocytes of the Brazilian tarantula Acanthoscurria gomesiana and can be produced…”
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Identification and characterization of a new family of cell-penetrating peptides: cyclic cell-penetrating peptides by Cascales, Laura, Henriques, Sónia T, Kerr, Markus C, Huang, Yen-Hua, Sweet, Matthew J, Daly, Norelle L, Craik, David J

“…Cell-penetrating peptides can translocate across the plasma membrane of living cells and thus are potentially useful agents in drug delivery applications…”
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Investigations into the membrane activity of arenicin antimicrobial peptide AA139 by Edwards, Ingrid A., Henriques, Sónia T., Blaskovich, Mark A.T., Elliott, Alysha G., Cooper, Matthew A.

“…Arenicin-3 is an amphipathic β-hairpin antimicrobial peptide that is produced by the lugworm Arenicola marina. In this study, we have investigated the…”
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Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7 by Agwa, Akello J., Lawrence, Nicole, Deplazes, Evelyne, Cheneval, Olivier, Chen, Rachel M., Craik, David J., Schroeder, Christina I., Henriques, Sónia T.

“…The human voltage-gated sodium channel sub-type 1.7 (hNaV1.7) is emerging as an attractive target for the development of potent and sub-type selective novel…”
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Synthesis, Structure, and Activity of the Antifungal Plant Defensin PvD1 by Skalska, Julia, Andrade, Vitor M, Cena, Gabrielle L, Harvey, Peta J, Gaspar, Diana, Mello, Érica O, Henriques, Sónia T, Valle, Javier, Gomes, Valdirene M, Conceição, Katia, Castanho, Miguel A. R. B, Andreu, David

“…Available treatments for invasive fungal infections have limitations, including toxicity and the emergence of resistant strains. Therefore, there is an urgent…”
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Angler Peptides: Macrocyclic Conjugates Inhibit p53:MDM2/X Interactions and Activate Apoptosis in Cancer Cells by Philippe, Grégoire J.-B, Mittermeier, Anna, Lawrence, Nicole, Huang, Yen-Hua, Condon, Nicholas D, Loewer, Alexander, Craik, David J, Henriques, Sónia T

“…Peptides are being developed as targeted anticancer drugs to modulate cytosolic protein–protein interactions involved in cancer progression. However, their use…”
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Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold by Huang, Yen-Hua, Henriques, Sónia T., Wang, Conan K., Thorstholm, Louise, Daly, Norelle L., Kaas, Quentin, Craik, David J.

“…The constitutively active tyrosine kinase BCR-ABL is the underlying cause of chronic myeloid leukemia (CML). Current CML treatments rely on the long-term use…”
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A designed cyclic analogue of gomesin has potent activity against Staphylococcus aureus biofilms by Dias, Susana, Pinto, Sandra, Silva-Herdade, Ana S., Cheneval, Olivier, Craik, David J, Coutinho, Ana, Castanho, Miguel, Henriques, Sónia T., Veiga, Ana Salome

“…© The Author(s) 2022. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy. This is an Open Access article…”
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Computer-Aided Design of Mastoparan-like Peptides Enables the Generation of Nontoxic Variants with Extended Antibacterial Properties by Oshiro, Karen G. N, Cândido, Elizabete S, Chan, Lai Y, Torres, Marcelo D. T, Monges, Bruna E. D, Rodrigues, Silvia G, Porto, William F, Ribeiro, Suzana M, Henriques, Sónia T, Lu, Timothy K, de la Fuente-Nunez, Cesar, Craik, David J, Franco, Octávio L, Cardoso, Marlon H

“…Diverse peptides have been evaluated for their activity against pathogenic microorganisms. Here, five mastoparan variants were designed based on mastoparan-L,…”
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The circular bacteriocin enterocin NKR-5-3B has an improved stability profile over nisin by Wang, Conan K., Huang, Yen-Hua, Shabbir, Fatima, Pham, Huong T., Lawrence, Nicole, Benfield, Aurélie H., van der Donk, Wilfred, Henriques, Sónia T., Turner, Mark S., Craik, David J.

“…Bacteriocins are a large family of bacterial peptides that have antimicrobial activity and potential applications as clinical antibiotics or food…”
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Peptide-based LDH5 inhibitors enter cancer cells and impair proliferation by Nadal-Bufí, Ferran, Chan, Lai Y., Mohammad, Hadi H., Mason, Jody M., Salomon, Carlos, Lai, Andrew, Thompson, Erik W., Craik, David J., Kaas, Quentin, Henriques, Sónia T.

“…Lactate dehydrogenase 5 (LDH5) is overexpressed in many cancers and is a potential target for anticancer therapy due to its role in aerobic glycolysis…”
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Gating modifier toxin interactions with ion channels and lipid bilayers: Is the trimolecular complex real? by Agwa, Akello J., Henriques, Sónia T., Schroeder, Christina I.

“…Spider peptide toxins have attracted attention because of their ability to target voltage-gated ion channels, which are involved in several pathologies…”
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Evaluation of Cyclic Peptide Inhibitors of the Grb7 Breast Cancer Target: Small Change in Cargo Results in Large Change in Cellular Activity by Sang, Jianrong, Kulkarni, Ketav, Watson, Gabrielle M, Ma, Xiuquan, Craik, David J, Henriques, Sónia T, Poth, Aaron G, Benfield, Aurélie H, Wilce, Jacqueline A

“…Grb7 is an adapter protein, overexpressed in HER2+ve breast and other cancers, and identified as a therapeutic target. Grb7 promotes both proliferative and…”
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New Potent Membrane-Targeting Antibacterial Peptides from Viral Capsid Proteins by Dias, Susana A, Freire, João M, Pérez-Peinado, Clara, Domingues, Marco M, Gaspar, Diana, Vale, Nuno, Gomes, Paula, Andreu, David, Henriques, Sónia T, Castanho, Miguel A R B, Veiga, Ana S

“…The increasing prevalence of multidrug-resistant bacteria urges the development of new antibacterial agents. With a broad spectrum activity, antimicrobial…”
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Lengths of the C-Terminus and Interconnecting Loops Impact Stability of Spider-Derived Gating Modifier Toxins by Agwa, Akello J, Huang, Yen-Hua, Craik, David J, Henriques, Sónia T, Schroeder, Christina I

“…Spider gating modifier toxins (GMTs) are potent modulators of voltage-gated ion channels and have thus attracted attention as drug leads for several…”
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Optimization of the cyclotide framework to improve cell penetration properties by Huang, Yen-Hua, Chaousis, Stephanie, Cheneval, Olivier, Craik, David J, Henriques, Sónia T

“…Cell penetrating peptides have been regarded as promising vectors to deliver hydrophilic molecules inside cells. Although they are great tools for research and…”
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Synthesis, Structure, and Activity of the Antifungal Plant Defensin Pv D 1 by Skalska, Julia, Andrade, Vitor M, Cena, Gabrielle L, Harvey, Peta J, Gaspar, Diana, Mello, Érica O, Henriques, Sónia T, Valle, Javier, Gomes, Valdirene M, Conceição, Katia, Castanho, Miguel A R B, Andreu, David

“…Available treatments for invasive fungal infections have limitations, including toxicity and the emergence of resistant strains. Therefore, there is an urgent…”
Get full text